Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Gastroenterologist Jobs in South Dakota

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$160K - $200K *

Drive growth in a leading Cyber Consulting Services organization by enhancing operational performance, managing diverse teams, and delivering high-quality cybersecurity solutions while ensuring client...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$225K - $281K *

Lead the charge in shaping detection and response strategies, driving hands-on initiatives to enhance security architecture and incident management. Collaborate across teams to ensure robust threat de...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$195K - $256K *

Elevate clinical quality assurance by designing and executing strategies for compliance, audit management, and oversight of global clinical operations. Collaborate with stakeholders to ensure adherenc...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$251K - $307K *

Champion innovative patient marketing strategies that drive engagement and awareness for a first-in-class therapy in Becker muscular dystrophy, collaborating across teams to enhance patient experience...

RemoteRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$175K - $251K *

Lead the charge in transforming customer experiences through innovative cloud security solutions, leveraging your expertise to craft tailored technical presentations and solutions that drive strategic...

RemoteRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$155K - $175K *

Drive impactful scientific engagement by building relationships with key stakeholders, translating clinical data into actionable insights, and ensuring successful product adoption in a dynamic prelaun...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$113K - $188K *

Optimize security administration and reporting processes while collaborating with cross-functional teams to enhance data insights and compliance metrics. Drive effective use of Workday tools and ensur...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Business Services

$152K - $253K *

Lead strategic health informatics initiatives to enhance care delivery by partnering with health systems and GSK teams, translating data insights into actionable improvements in patient care and opera...

Reposted 2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$114K - $187K *

Champion clinical laboratory operations by managing complex projects, ensuring timely study starts, and collaborating with cross-functional teams to deliver impactful results in precision medicine...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $150K *

Unlock your potential as a key resource in power plant consulting, focusing on generator engineering. Collaborate with industry leaders to deliver innovative solutions while enjoying a flexible remote...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$181K - $301K *

Transform your career by leading a global cyber defense team, driving proactive strategies to mitigate risks and enhance security across diverse environments. Collaborate with cross-functional teams t...

RemoteRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$195K - $244K *

Unlock your potential as a Global Regulatory Leader, driving regulatory strategy and submissions for CNS projects. Collaborate with cross-functional teams, mentor junior staff, and ensure compliance w...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$172K - $202K *

Lead innovative insights and strategies as a Senior Director, driving impactful research and analysis to empower clients in navigating complex market challenges and achieving their business objectives...

RemoteRemote

2 weeks ago

  •   11 - 15 years exp.  •   Business Services

$230K - $345K *

Shape the future of late-stage oncology clinical trials by leading strategic initiatives, ensuring operational excellence, and fostering cross-functional partnerships to drive successful trial executi...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$83K - $129K *

Lead the charge in advanced compliance activities, ensuring administrative solutions align with laws and regulations. Utilize AI tools to enhance efficiency, guide teams, and deliver scalable complian...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Drive the month-end close process by ensuring accurate revenue recognition and analysis. Collaborate across departments to produce insightful reports and support financial decision-making while adheri...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$179K - $280K *

Unlock potential by driving strategic revenue cycle performance and enhancing client partnerships. Lead initiatives across Self-Pay and Patient Financial Experience, leveraging data to influence decis...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$100K *

Elevate sales strategies by owning the full sales cycle, building C-Suite relationships, and delivering impactful solutions to healthcare organizations across the Western US...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Explore advanced revenue analysis and month-end controls to ensure accurate invoicing and financial reporting. Collaborate across functions to resolve discrepancies, mentor junior analysts, and drive...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$190K - $200K *

Elevate your career by driving sales strategy and execution for a dynamic SaaS portfolio. Lead a high-performing team to achieve revenue growth, optimize pipeline management, and enhance customer acqu...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Food & Beverages

$150K - $180K *

Champion end-to-end contract management and corporate compliance, driving legal support for commercial and federal agreements while collaborating across departments to ensure efficient deal closure an...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$120K - $145K *

Join a team that's dedicated to safeguarding sensitive health information while enhancing security across cloud and application environments. As a Senior Security Engineer, you'll design and implement...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$225K - $418K *

Champion advanced analytics to enhance patient outcomes through data-driven insights. Lead a team in analyzing healthcare data, fostering strategic partnerships, and communicating complex findings to...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$163K - $204K *

Unlock potential by leading innovative machine learning methods for cancer detection, collaborating with experts, and mentoring junior scientists to advance research in multi-cancer early detection us...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$172K - $202K *

Lead the charge in delivering expert guidance on identity and access management technologies, focusing on architecting solutions and producing actionable research to enhance client performance and sec...

RemoteRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.