Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Remote Quality Improvement Data Analyst
$70K - $106K *
Transform operational data into actionable insights while collaborating with cross-functional teams to support business decisions and enhance efficiency. Leverage analytical skills to drive performanc...
Reposted 3 days ago
Director, GCP Inspection Management- Americas
$172K - $232K *
Lead the GCP Inspection Management team to ensure inspection readiness and compliance. Oversee strategy development, cross-functional collaboration, and risk mitigation for successful regulatory inspe...
3 weeks ago
Clinical Liaison and Market Dev. Leader
$110K - $130K *
Join a team that's driving innovation in transplant advocacy by integrating business development, marketing, and medical expertise. Collaborate with key stakeholders to enhance KOL engagement and mark...
3 weeks ago
$164K - $273K *
Join a team that's advancing global scientific engagement through strategic conference planning and execution. Collaborate across functions to elevate medical affairs and enhance the impact of evidenc...
Reposted 3 weeks ago
Executive Director, HEOR Modeling
$175K - $210K *
Unlock potential by leading HEOR strategy and AI integration, ensuring project success and client satisfaction. Drive business growth, mentor teams, and influence health policy through innovative rese...
Yesterday
Vice President, Growth (Pharma)
$150K - $200K *
Join a dynamic team to drive growth in the pharmaceutical sector, leveraging your expertise to build relationships, win new business, and deliver impactful solutions that enhance brand performance and...
Today
$92K - $167K *
Unlock potential by developing and maintaining scalable applications, integrating new technologies, and participating in Agile methodologies to enhance product features and client solutions...
Reposted today
Corporate Charge Capture Auditor, Outpatient
$63K - $101K *
Optimize compliance in Interventional Radiology charge capture by conducting audits, educating teams, and enhancing coding practices. Collaborate with clinical departments to identify and rectify codi...
3 weeks ago
Director of Market Development & Referral Strategy
$110K - $130K *
Lead the charge in developing referral growth and market strategies across multiple states. Drive sustainable growth by optimizing processes, leveraging CRM systems, and building high-performing teams...
2 days ago
Staff Biostatistician (Clinical Validation)
$164K - $205K *
Lead the design and analysis of clinical validation studies, ensuring regulatory compliance and driving innovative research in molecular diagnostics. Collaborate with cross-functional teams to enhance...
2 weeks ago
Manager of Bioinformatics (Oncology Product Development)
$140K - $175K *
Lead the charge in advancing oncology diagnostics by managing a team of bioinformaticians and data scientists, driving product development, and ensuring high-quality analysis and validation of ctDNA-b...
Yesterday
Medical Physicist | Radiation Oncology Cancer Care Institute
$187K - $234K *
Join a team that's dedicated to ensuring the safety and effectiveness of cancer treatments. Utilize your expertise in medical physics to conduct quality assurance, develop clinical protocols, and supp...
Reposted today
Principal Scientist, Process Chemistry
$165K - $185K *
Lead drug substance activities in process chemistry, driving projects from early to late phases. Collaborate with cross-functional teams to ensure successful manufacturing and regulatory submissions...
3 weeks ago
GEO Strategy & Operations Senior Manager, RDBU & Global
$143K - $194K *
Advance your career by driving GEO strategy and operations, coordinating cross-functional efforts, and optimizing digital marketing initiatives for a global brand portfolio in a dynamic and collaborat...
Reposted today
Senior Scientific Director, Neurodegenerative Diseases
$265K - $300K *
Shape the future of neurodegenerative disease diagnostics by leading scientific strategy, driving research programs, and building expert networks to establish industry leadership in innovative solutio...
1 month ago
VICE PRESIDENT, OPERATIONS (SOUTHEAST)
$180K - $220K *
Drive the future of healthcare operations by leading a $300M portfolio, fostering physician partnerships, and executing growth strategies while managing financial and operational performance for a dyn...
Reposted 1 week ago
Senior Sales Executive, Enterprise Payments
$161K - $273K *
Transform client relationships and drive revenue growth by leveraging deep industry expertise and consultative selling skills. Collaborate with teams to deliver tailored payment solutions and lead com...
2 weeks ago
$90K - $110K *
Accelerate program implementation and stakeholder engagement in pharmaceutical market access. Oversee daily operations, client relations, and staff management while ensuring adherence to budgets and p...
Reposted 3 weeks ago
Director of US Oncology Portfolio Delivery
$169K - $282K *
Join a team that's redefining oncology clinical operations by leading a dynamic portfolio of studies. Drive excellence in delivery, manage complex projects, and mentor a talented team to ensure high-q...
Reposted 1 week ago
$73K - $100K *
Elevate workforce planning by transforming data into impactful insights. Partner with leaders to build strategic forecasting tools and measure performance metrics, contributing to operational efficien...
Reposted 3 days ago
South Central, Key Account Manager, Cattle
$80K - $95K *
Unlock potential by driving sales growth and fostering customer relationships in the cattle healthcare sector. Collaborate with a dynamic team to achieve strategic objectives and enhance brand presenc...
2 weeks ago
Internal Medicine Physician - Sioux Falls, SD
$300K *
Unlock potential by delivering expert wound management in a flexible, supportive environment. Enjoy autonomy with no nights, weekends, or call responsibilities while providing care across diverse faci...
4 weeks ago
Medical Safety Manager, Ambulatory Monitoring & Diagnostics
$133K - $237K *
Contribute to patient safety by overseeing medical product surveillance, analyzing data, and ensuring compliance with regulations. Collaborate on risk management and support clinical studies to enhanc...
6 days ago
$130K - $190K *
Empower veterinary professionals by delivering expert dermatology advice and support, enhancing case management, and fostering strong relationships. Join a dynamic team committed to advancing veterina...
Reposted yesterday
Nurse Practitioner or Physician Assistant | Hematology and Transplant | Inpatient
$90K - $110K *
Transform patient care by guiding Oncology patients through complex treatment plans, ensuring a smooth experience and providing essential medical services. Collaborate with healthcare teams to deliver...
Yesterday
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.