Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Clinical Sales Specialist, Pulmonary
$110K - $130K *
Unlock your potential by driving sales of innovative pulmonary solutions. Collaborate with diverse stakeholders to enhance patient care and achieve sales targets in a dynamic healthcare environment. J...
Reposted 4 days ago
$120K - $147K *
Shape your career by leading data integration initiatives that drive enterprise-wide consistency and governance. Collaborate with stakeholders to deliver trusted, scalable data products while ensuring...
1 week ago
Data Analyst (Healthcare Data Analytics)
$80K - $115K *
Analyze and enhance client data reporting, driving insights and trends to support customer satisfaction and business growth. Collaborate with cross-functional teams to ensure data integrity and delive...
3 weeks ago
$163K - $245K *
Shape security architecture by designing robust frameworks across various tech domains. Collaborate with cross-functional teams to ensure comprehensive cybersecurity solutions aligned with business go...
Reposted 3 weeks ago
$115K - $158K *
Join us to shape the future of member experiences in healthcare by leading innovative design projects, collaborating with cross-functional teams, and enhancing service delivery through user-centered d...
2 days ago
HIM Outpatient Coding Supervisor
$68K - $113K *
Lead the charge in optimizing coding accuracy and compliance by analyzing complex patient care documentation, providing expert guidance, and enhancing coder education to ensure adherence to ethical st...
3 weeks ago
Sr. Staff Engineer, Care (Fullstack/Backend)
$150K - $180K *
Innovate the future of architectural strategy by leading technical direction, fostering collaboration across teams, and driving scalable solutions that align with business goals while mentoring senior...
Yesterday
Sr. Advisor, Molecular Pharmacology - Neuroscience
$129K - $231K *
Reimagine drug discovery as you lead molecular pharmacology efforts in neuroscience. Collaborate across teams to develop strategies, interpret data, and advance innovative therapies for sleep-wake dis...
Reposted 3 days ago
$96K - $144K *
Take ownership of contract management by drafting, negotiating, and administering agreements with key customers. Collaborate with cross-functional teams to ensure compliance and operational efficiency...
Yesterday
$100K - $122K *
Unlock your potential as you lead financial planning, analytics, and strategic initiatives. Collaborate closely with executives to drive performance improvements and optimize resource allocation, fost...
Reposted 2 weeks ago
Director, BioPharma Business Development
$150K - $180K *
Unlock potential by driving BioPharma partnership success through innovative liquid biopsy solutions, enhancing clinical trial designs, and fostering key relationships in oncology precision medicine...
Reposted 1 week ago
Executive Director, Health Economics & Outcomes Research (HEOR)
$246K - $332K *
Shape the future of health economics and outcomes research by leading strategic initiatives across the nephrology portfolio, ensuring high-quality evidence generation and collaboration with cross-func...
1 week ago
Vice President Enterprise Sales - Texas
$205K - $380K *
Accelerate progress at enterprise sales by driving strategic growth initiatives, building relationships with healthcare leaders, and leading complex sales pursuits to enhance market presence and custo...
4 weeks ago
Director, Field Effectiveness, Rare Disease and Oncology
$193K - $262K *
Champion the sales force's success by leading a dynamic team focused on optimizing field effectiveness and operational efficiency, driving excellence in performance and insights...
1 month ago
Genesys Cloud Access Management
$89K - $121K *
Shape the future of customer engagement by optimizing Genesys Cloud access management. Collaborate with cross-functional teams to enhance security, streamline user provisioning, and ensure compliance...
1 week ago
$120K - $150K *
Transform customer experiences by leading a high-performing team, driving retention and growth strategies, and leveraging AI to enhance service delivery. Be the voice of the customer while collaborati...
Reposted today
Quality Compliance & AI Operations Analyst
$80K - $90K *
Advance quality assurance initiatives and optimize workflows in a remote healthcare contact center. Collaborate cross-functionally to enhance compliance, improve patient outcomes, and drive continuous...
1 week ago
Informatics Lead, Clinical Intelligence
$117K - $161K *
Drive impactful clinical intelligence initiatives by analyzing AI opportunities, conducting feasibility studies, and collaborating with cross-functional teams to enhance patient care and operational e...
2 weeks ago
$130K - $216K *
Lead complex healthcare data initiatives by managing teams, translating business needs into technical solutions, and ensuring data quality and integration. Collaborate with stakeholders to drive analy...
Yesterday
$225K - $265K *
Transform healthcare interoperability by leading product strategy and market growth. Leverage deep industry insights to enhance payer-provider collaboration, drive operational excellence, and oversee...
1 month ago
Sr Manager, Global Regulatory Affairs (AI/ML)
$150K - $180K *
Unlock potential by guiding global regulatory strategies for innovative AI/ML healthcare solutions. Collaborate cross-functionally to navigate complex regulations while balancing innovation and patien...
Reposted 4 weeks ago
Medical Director, Utilization Management
$180K - $220K *
Lead the evaluation of outpatient referrals and inpatient admissions for medical necessity, utilizing guidelines and criteria to ensure quality care. Collaborate with providers and mentor UM nurses to...
Yesterday
Care Manager, Telephonic Nurse
$71K - $97K *
Transform patient care by guiding transitions and ensuring optimal service continuity. Leverage your nursing expertise to navigate healthcare options and advocate for patients in need of post-acute se...
Yesterday
Account Executive, Government & Public Sector
$105K - $140K *
Transform your career by leading government sales efforts in a high-growth environment. Leverage your expertise to build relationships, create pipelines, and drive revenue for a cutting-edge product i...
2 weeks ago
Lead Clinical Pharmacist, Oncology Programs
$120K - $145K *
Join a team that's redefining oncology care by overseeing clinical standards, evaluating therapies, and engaging with providers. You'll play a key role in shaping patient eligibility and treatment pro...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.