Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$175K - $210K *
Elevate your career by owning the sales cycle for major employers, building strategic partnerships, and driving innovative health programs that shape enterprise success and market presence...
1 month ago
$69K - $104K *
Unlock your potential by collaborating with leaders to enhance payor performance, streamline revenue cycle operations, and drive innovation in healthcare. Your expertise will ensure impactful engageme...
Today
Sr. Program Intelligence & Performance Management Consultant
$115K - $163K *
Drive impactful performance insights by defining and managing the measurement framework for ancillary product portfolios, ensuring strategic alignment and regulatory compliance while advising leadersh...
3 weeks ago
Medical Affairs and Evidence Generation Asset Lead – Executive Director
$325K - $447K *
Elevate medical affairs by providing strategic insights for clinical asset development and commercialization. Lead cross-functional teams, execute evidence generation plans, and foster collaboration t...
Reposted 1 week ago
Assistant Director, Global Service Delivery
$100K - $120K *
Advance global service delivery by managing offshore partnerships, ensuring performance excellence, and driving operational improvements across teams to enhance productivity and quality outcomes...
6 days ago
CMC Program Lead - Illuccix and Gozellix
$125K - $150K *
Join a team that's dedicated to advancing radiopharmaceuticals! Lead CMC strategies and cross-functional collaboration to ensure successful readiness for commercial viability, market expansion, and co...
4 weeks ago
Project Manager, Business Improvement
$100K - $120K *
Empower your career by driving impactful business improvement initiatives. Collaborate with cross-functional teams to manage projects, analyze data, and enhance operational efficiency in a dynamic env...
2 weeks ago
Manager, Applications, Epic Orders
$165K - $264K *
Pioneer cross-functional collaboration to manage IS projects, ensuring successful implementation and support of applications, upgrades, and integrations while overseeing budgets and resources across S...
2 days ago
Director, Biologics Process Development
$223K - $233K *
Deliver strategic leadership in biologics process development, overseeing outsourced manufacturing and ensuring alignment with corporate goals while driving technical excellence in late-stage developm...
1 month ago
Product Sales Specialist- Anesthesia & Respiratory Care (SF Bay Area)
$95K - $143K *
Unlock growth in the healthcare market by driving sales strategy for anesthesia and respiratory care products in the San Francisco Bay area, fostering relationships, achieving revenue targets, and lev...
Reposted yesterday
Senior Director, Global Revenue Accounting and Order to Cash
$234K - $322K *
Transform global revenue accounting and order-to-cash processes in a dynamic healthcare environment. Lead a high-performing team, ensuring compliance with U.S. GAAP and driving systems improvements fo...
1 week ago
Senior Risk Adjustment Coding Analyst
$86K - $118K *
Join a team that's dedicated to enhancing consumer experiences through innovative solutions. Leverage your technical expertise in a collaborative environment focused on continuous improvement and impa...
Reposted today
Senior Consultant, Advisory Services
$90K - $150K *
Elevate healthcare performance by leading analytics-driven consulting engagements. Collaborate with clients to identify needs, deliver insights, and implement solutions while managing project economic...
4 weeks ago
$135K - $160K *
Lead the strategic design and management of comprehensive benefits programs, ensuring alignment with employee needs and company objectives. Drive innovation and compliance while enhancing employee eng...
Yesterday
Director, Disease Area Strategy Lead - General Medicine
$195K - $265K *
Lead the strategic direction of General Medicine, integrating scientific and commercial insights to drive portfolio decisions and early pipeline projects, while fostering cross-functional collaboratio...
3 weeks ago
Senior Clinical Project Manager
$120K - $145K *
Join a team that's advancing oncology solutions by managing global clinical trials. Lead project execution from protocol development to study closeout, ensuring quality and compliance while fostering...
2 weeks ago
$87K - $157K *
Unlock compliance excellence by managing auditing, monitoring, and reporting processes to ensure adherence to regulatory standards and enhance operational efficiency across contracts and collaboration...
1 month ago
$102K - $184K *
Elevate your career by leading market-level financial reporting and performance management in value-based healthcare. Collaborate with stakeholders to drive insights and outcomes, ensuring disciplined...
6 days ago
Senior Regulatory Submissions Lead
$145K *
Drive innovation and transform lives by leading regulatory strategies and submissions for clinical trials globally. Act as a key liaison for project teams to ensure compliance, operational excellence...
Reposted 1 week ago
Associate Clinical Applications Specialist, Cardiology - Bracco Diagnostics Inc
$80K - $95K *
Unlock potential by providing expert support and training for Nuclear Medicine and PET customers, enhancing satisfaction and service quality for CardioGen-82 users through education, troubleshooting...
3 weeks ago
Senior Scientific Director - Oncology (Medical Affairs & Commercial Medical Education)
$160K - $190K *
Champion the development and oversight of scientific content across diverse therapeutic areas while managing client relationships and brand strategy for multiple accounts, ensuring high-quality and im...
Reposted 3 weeks ago
Associate Director, Compliance Field Commercialization, Lung
$177K - $221K *
Empower compliance excellence by leading the NSCLC field compliance program. Collaborate with cross-functional teams to identify risks, develop scalable solutions, and ensure adherence to regulations...
2 weeks ago
$110K - $130K *
Drive impactful solutions as you lead integration efforts, enhancing user experiences through collaboration and innovation while managing multiple complex projects and mentoring junior engineers...
4 weeks ago
Sr Global Product Manager, Digital Solutions - Surgical & Procedural Care
$149K - $224K *
Lead the charge in shaping digital solutions for perioperative workflows, driving strategy and execution across cross-functional teams to enhance clinical outcomes and operational efficiency in surgic...
6 days ago
Clinical Sciences Director, Oncology
$211K - $285K *
Lead the charge in late-phase oncology clinical development, collaborating across teams to design and deliver impactful results. Provide expertise in clinical trial science and data analysis, ensuring...
Today
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.