Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$150K - $180K *
Elevate data privacy standards by leading a comprehensive privacy program. Collaborate across teams to integrate privacy-by-design principles, enhance data governance, and ensure compliance while enab...
2 weeks ago
Ambulatory Client Sales Executive
$100K - $120K *
Serve as the primary contact for clients, driving engagement and service quality while fostering relationships with key stakeholders and leveraging expertise to enhance organizational growth and clien...
Reposted 2 weeks ago
Thought Leader Liaison, US Oncology, Northeast
$167K - $300K *
Elevate oncology marketing strategies by leading KOL engagement and advocacy initiatives. Utilize market insights to shape brand strategy and launch planning for innovative therapies, ensuring complia...
3 days ago
Regional Sales Director - Atlanta
$180K - $215K *
Shape the future of our commercial launch by leading a regional sales team to drive market entry, foster customer relations, and exceed performance goals in a dynamic, cross-functional environment...
Reposted 2 weeks ago
Lead Project Manager, Delivery
$115K - $158K *
Join a team that's driving innovation in project management for enterprise decisioning. Collaborate across business and technology teams to ensure successful delivery of complex initiatives while main...
2 days ago
$195K - $217K *
Drive client success by leading strategic initiatives and fostering strong relationships in healthcare technology. Leverage deep domain expertise to enhance outcomes and ensure effective use of soluti...
1 week ago
Manager, Market Access & Reimbursement
$145K - $218K *
Architect innovative market access strategies to enhance U.S. reimbursement for cutting-edge healthcare solutions. Collaborate across functions to drive payer engagement, coding, and coverage initiati...
2 weeks ago
$88K - $105K *
Join a team that's dedicated to delivering exceptional client service and operational excellence. As a Program Manager, you'll oversee program execution, account management, and financial oversight wh...
2 weeks ago
$120K - $145K *
Elevate healthcare reimbursement processes by leading legal strategies on billing disputes and regulatory compliance. Collaborate with teams to create innovative solutions and build legal frameworks t...
1 week ago
$80K - $90K *
Champion project success by managing timelines, resources, and stakeholder communication. Drive seamless implementation experiences while collaborating with cross-functional teams to deliver value-dri...
3 weeks ago
$110K - $130K *
Contribute to impactful consulting services in government pricing, leveraging your expertise to guide clients through compliance, data analysis, and strategic initiatives while leading a collaborative...
2 days ago
Regional Director, Clinical Sales - Central
$150K - $180K *
Transform the clinical sales landscape by leading a regional team to drive utilization growth, enhance patient treatment metrics, and foster cross-functional collaboration for commercial success in in...
4 weeks ago
Senior Bioinformatics Scientist
$117K - $146K *
Lead the charge in developing innovative algorithms and pipelines for early cancer detection, collaborating with cross-functional teams to analyze complex genomic datasets and enhance clinical diagnos...
Yesterday
$85K - $97K *
Shape the future of healthcare by conducting clinical case reviews and enhancing product quality for an AI-driven clinical platform. Collaborate with care teams to ensure accurate alert functionality...
4 weeks ago
Senior Regulatory Affairs Specialist
$83K - $103K *
Drive success in regulatory affairs by preparing critical submissions for medical and diagnostic devices. Oversee compliance with U.S. and international regulations while collaborating with cross-func...
Reposted 1 week ago
Regional Director - Hematology - Ohio Valley
$212K - $287K *
Transform the Hematology landscape by leading a high-performing sales team, driving strategic initiatives, and ensuring compliance while exceeding sales objectives in the Great Plains region...
2 days ago
Director, CAHPS and HOS Strategy and Execution
$130K - $195K *
Innovate member experience strategies by translating enterprise goals into actionable plans. Drive performance improvements in CAHPS and HOS programs through provider engagement and data analysis, ens...
1 week ago
$110K - $130K *
Join a team that's dedicated to enhancing client relationships and driving success. Oversee client performance, mentor staff, and ensure compliance while collaborating with various departments to deli...
Reposted yesterday
$110K - $130K *
Champion client success by overseeing relationships, ensuring operational excellence, and mentoring teams to exceed expectations. Utilize analytics to drive performance and resolve issues, fostering c...
6 days ago
Senior Manager, Precision Medicine - Clinical Diagnostics
$150K - $245K *
Drive the execution of companion diagnostics strategy, managing cross-functional teams and partnerships to ensure successful assay development and regulatory compliance, ultimately enhancing patient o...
2 weeks ago
Senior Sales Specialist – Government Risk State Business
$199K - $370K *
Optimize your sales expertise by driving revenue in state government sectors. Leverage your knowledge of procurement processes to build relationships and close deals, while collaborating with a top-ti...
3 weeks ago
Clinical Consultant (Vue PACS)
$90K - $143K *
Unlock potential by serving as a clinical consultative partner, guiding healthcare customers through PACS solutions, ensuring successful implementation, and fostering strong relationships to drive cus...
Reposted today
Principal Clinical Content- Physician (Clinical AI Strategist - UpToDate®) - Partnerships
$173K - $310K *
Transform clinical AI solutions by leveraging your expertise in patient care and research. Collaborate cross-functionally to enhance clinical accuracy and support strategic partnerships, ensuring the...
2 weeks ago
Quality Control, Validation Lead
$110K - $130K *
Join a team that's shaping the future of Quality Control laboratories by providing technical oversight for startup, validation, and compliance across multiple manufacturing sites, ensuring operational...
2 weeks ago
$115K - $158K *
Shape the future of healthcare by leading the Organic Risk Adjustment program. Drive strategic initiatives, foster collaboration across teams, and implement innovative solutions to enhance performance...
2 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.