Explore $100K+ Jobs in Oklahoma

Find professional opportunities across Oklahoma with salaries of $100,000 or more. Ladders features vetted jobs for experienced candidates seeking leadership, specialized, and other high-paying roles. Explore openings in Oklahoma City, Tulsa, and communities throughout the state, and discover opportunities that match your skills and career goals.

High-Paying Careers Across Oklahoma

Oklahoma’s economy includes established industries such as energy, aerospace, healthcare, manufacturing, finance, and technology. Employers may seek experienced professionals for roles in operations, engineering, corporate leadership, sales, information technology, and clinical or administrative management. Available positions and compensation vary by employer, location, experience, and specialization.

Find the Right Role for Your Experience

Use Ladders to explore vetted professional job listings and focus your search on roles with compensation of $100,000 or more. Review each posting for its responsibilities, qualifications, location, and compensation details. Set up a strong profile and tailor your resume to highlight measurable results, relevant expertise, and leadership experience.

Search Oklahoma Jobs on Ladders

Whether you’re considering a move to Oklahoma or looking to advance your career close to home, browse current high-paying opportunities and apply to positions that fit your background. New listings may appear as employers’ needs change, so check back regularly for the latest Oklahoma jobs.

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$189K - $246K *

Lead clinical pharmacology strategies, integrating PK/PD assessments across development phases. Collaborate with cross-functional teams to guide decision-making and regulatory submissions, ensuring al...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$190K - $300K *

Champion scientific exchange and research initiatives in gastrointestinal immunology, engaging with key scientific leaders to enhance understanding and support clinical trials while fostering an inclu...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $90K *

Shape the future of Cell and Gene Therapy by providing expert application support, driving customer integration, and enhancing product utilization through collaboration and technical guidance across t...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$98K - $132K *

Transform healthcare by leading Risk Adjustment strategies and educational initiatives. Collaborate with teams to enhance coding accuracy and documentation, ensuring compliance and delivering impactfu...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$130K - $150K *

Lead the charge in integrating complex hospital data systems into Astra OS. Own end-to-end data pipelines, collaborate with customers, and design scalable solutions that enhance healthcare operations...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$111K - $167K *

Empower your career by leading IT systems development, implementation, and maintenance. Oversee complex networks, ensure security, and drive automation, all while collaborating to enhance operational...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Elevate market presence by driving adoption of innovative cardiac imaging solutions. Collaborate with healthcare professionals to enhance patient care, achieve sales targets, and optimize business str...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$76K - $114K *

Unlock potential by driving growth in Electrophysiology-focused Ambulatory Surgery Centers. Leverage clinical expertise to build relationships, enhance product adoption, and ensure customer satisfacti...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$174K - $224K *

Empower organizations by shaping data governance strategies that enhance security, compliance, and operational resilience. Collaborate with cross-functional teams to deliver impactful governance solut...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$175K - $250K *

Join a team that's optimizing medical cost management and driving financial performance across Commercial lines. Leverage your expertise in healthcare economics to influence strategic contracting and...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$272K - $340K *

Elevate your career by leading CMC Regulatory strategy and execution. Drive submissions, build a high-performing team, and engage with global health authorities to ensure compliance and success in dru...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$180K - $220K *

Drive the enterprise data strategy and governance, ensuring data quality, compliance, and accessibility. Lead cross-functional teams to foster a data-rich culture, enabling advanced analytics and AI r...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Healthcare

$100K - $120K *

Engage with a dynamic oncology team to provide expert patient care, education, and support. Collaborate closely with physicians to manage treatment plans and enhance patient outcomes in a fast-paced h...

Yesterday

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Join a team that's dedicated to enhancing contract management and customer experience. Leverage your expertise in contract administration and customer service to streamline processes and ensure compli...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead the quality assurance efforts for commissioning, qualification, and validation across multiple manufacturing sites, ensuring compliance with cGMP standards while collaborating with cross-function...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Join us to lead clinical excellence and enhance patient care across departments. Drive strategic initiatives, manage interdisciplinary teams, and ensure compliance with standards while fostering a cul...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$240K - $260K *

Drive strategic account growth by leveraging healthcare expertise and building strong relationships. Collaborate with cross-functional teams to deliver tailored solutions, enhance customer satisfactio...

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$150K - $180K *

Join a dynamic team to lead and scale clinical operations, overseeing performance and process optimization. Build accountable teams, manage metrics, and partner with stakeholders to enhance operationa...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$160K - $190K *

Pioneer innovative AI solutions to transform biomedical discovery, collaborating with top scientists and engineers to bridge virtual and real-world data, enhancing drug discovery and clinical care pro...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Transform financial operations by providing strategic support to business units, leading forecasting, and enhancing financial performance through collaboration and mentorship. Drive initiatives that p...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$181K - $291K *

Lead the charge in managing the full systems development lifecycle for enterprise applications, ensuring data quality and integrity while evolving best practices across healthcare operations and suppo...

RemoteRemote

2 days ago

  •   11 - 15 years exp.  •   Healthcare

$108K - $156K *

Empower your career by leading revenue analytics, overseeing financial analysis, and enhancing payer contract strategies. Collaborate with cross-functional teams to optimize reimbursement and drive or...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$85K - $100K *

Transform healthcare analytics by supporting ACOs in the MSSP program. Leverage data-driven insights to track performance metrics, optimize risk scores, and collaborate with teams to enhance value-bas...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$111K - $167K *

Join a team that's driving healthcare transformation by leading client integration initiatives. Collaborate across departments to ensure seamless transitions, operational readiness, and long-term succ...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$115K - $140K *

Drive GRC initiatives by building and testing security controls, assessing risks, and automating evidence collection. Collaborate with teams to enhance compliance and support audits while ensuring eff...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs can I find in Oklahoma?question toggle

    Listings may include professional and leadership roles in areas such as energy, aerospace, healthcare, technology, manufacturing, finance, engineering, operations, and sales. Job availability and compensation vary.

  • Which Oklahoma cities have high-paying job opportunities?question toggle

    Opportunities may be available in Oklahoma City, Tulsa, and other communities across the state. Check each listing for its location and whether remote or hybrid work is offered.

  • Does Ladders list jobs that pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with compensation of $100,000 or more. Review individual postings for specific salary information and qualifications.

  • How can I find Oklahoma jobs that fit my experience?question toggle

    Search current listings and compare each role’s requirements, responsibilities, location, and compensation. Tailor your resume to emphasize relevant skills, accomplishments, and experience.