Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$120K - $160K *

Champion the design and implementation of scalable data pipelines, ensuring data integrity and availability. Collaborate with cross-functional teams to optimize data workflows and enhance infrastructu...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Join a team that's dedicated to delivering successful projects on time and on budget. As a key player, you'll drive project planning, coordinate with stakeholders, and ensure effective communication t...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $150K *

Drive client engagement and solution development in digital banking, leveraging expertise in banking technology and pre-sales. Collaborate with teams to deliver tailored solutions and impactful demons...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$101K - $136K *

Transform clinical documentation by crafting high-quality regulatory submissions. Collaborate with cross-functional teams to ensure compliance with FDA and ICH guidelines while managing timelines and...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Elevate project delivery by leading cross-functional teams in Interactive Response Technology, ensuring client satisfaction and timely execution while managing risks and fostering continuous improveme...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$141K - $211K *

Transform clinical and revenue-cycle operations by leading cross-functional teams to optimize technology solutions, ensuring efficient charge capture and financial reporting while enhancing patient sa...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Join a dynamic pharmacy team to enhance operations and lead staff development. Drive quality, consistency, and continuous improvement while ensuring effective medication management and safety protocol...

Today

  •   Less than 5 years exp.  •   Healthcare

$90K - $110K *

Shape the future of technical content by building a robust function from the ground up, focusing on client engagement and leveraging emerging technologies to enhance understanding and communication...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$170K - $220K *

Drive product strategy and development to enhance clinician experience, optimizing patient care through innovative solutions and stakeholder collaboration across a nationwide healthcare network...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$177K - $221K *

Champion regulatory excellence by leading cross-functional teams, ensuring compliance, and driving successful oncology drug development through strategic planning and expert guidance...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$95K - $158K *

Champion high-availability database platforms, driving automation and cloud modernization. Collaborate with engineering teams to enhance reliability and performance across hybrid environments, ensurin...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$80K - $90K *

Elevate your career by building and maintaining a network of specialist consultants and physicians. Drive business growth and enhance clinical trial delivery through strong relationships and strategic...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$175K - $220K *

Shape the future of healthcare real estate by leading a dynamic transaction management team. Oversee negotiations, staff development, and strategic planning to drive client success and enhance operati...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$95K - $115K *

Champion compliance and security excellence by driving NIST 800-53 and FedRAMP initiatives. Partner with clients to ensure federal authorization, author vital documents, and manage multiple A&A projec...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Unlock growth potential by managing strategic accounts and cultivating executive relationships. Drive revenue through tailored strategies and consultative selling, while aligning cross-functional team...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$116K - $167K *

Elevate your career by leading planned giving strategies and donor engagement. Collaborate across teams to enhance legacy giving, cultivate relationships, and drive philanthropic support while managin...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$100K - $120K *

Drive the development and integration of advanced nuclear energy systems by applying systems engineering methods to translate objectives into clear, verifiable requirements and solutions, while collab...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$200K - $250K *

Shape the future of enterprise solutions by bridging technical expertise and strategic vision. Collaborate with cross-functional teams to design impactful architectures that drive customer success and...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$157K - $196K *

Drive safety evaluation and risk management for assigned programs, collaborating with cross-functional teams to ensure compliance and effective governance in pharmacovigilance activities, while suppor...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Unlock your potential as a key player in our Special Projects Division, driving construction excellence through effective planning, communication, and safety compliance while managing project schedule...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Media

$196K - $210K *

Partner with us to shape the future of semiconductor workforce development by aligning industry needs with educational strategies, fostering partnerships, and leading initiatives that ensure technical...

United StatesRemote

Reposted yesterday

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$222K - $278K *

Manage strategic enterprise customer relationships, drive complex sales cycles, and inspire transformation through innovative solutions, impacting industries that power our world and enhancing efficie...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$175K - $210K *

Drive the development and execution of U.S. pricing and contracting strategies, optimizing patient access and revenue performance. Collaborate across functions to ensure successful commercialization a...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$112K - $179K *

Transform the contract management landscape by expertly overseeing diverse government contracts, optimizing processes, and guiding teams to success from proposal to closeout while fostering robust sta...

United StatesRemote

Reposted 6 days ago

  •   11 - 15 years exp.  •   Aerospace & Defense

$112K - $179K *

Take ownership of a diverse portfolio of GSA/GWAC contracts, ensuring compliance and operational excellence through strategic management, collaboration with stakeholders, and training initiatives for...

United StatesRemote

1 month ago

  •   8 - 10 years exp.  •   Aerospace & Defense

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.