Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$86K - $138K *

Transform documentation practices by leading accessibility initiatives, ensuring compliance with federal standards, and mentoring a team of writers to enhance the quality and efficiency of deliverable...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Aerospace & Defense

$130K - $170K *

Partner with us to enhance consultant relationships in healthcare. Drive business growth by cultivating partnerships, optimizing engagement strategies, and aligning internal teams to effectively posit...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Healthcare

$140K - $185K *

Unlock the power of enterprise data as you design and implement Master Data Management solutions that enhance healthcare operations, drive analytics, and enable AI-driven decision-making with trusted...

RemoteRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$152K - $202K *

Drive patient access by leveraging your expertise in reimbursement and market access. Collaborate with healthcare providers to navigate complex payer landscapes, ensuring timely access to therapies wh...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$90K *

Support the optimization and configuration of Epic EHR systems, collaborating with clinical teams to enhance workflows, ensure compliance, and provide technical assistance, while maintaining system pe...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$90K *

Lead the charge in optimizing clinical workflows by configuring and supporting Epic EHR systems. Collaborate with healthcare teams to enhance system performance, ensure compliance, and provide trainin...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$90K *

Shape the future of healthcare technology by optimizing Epic EHR systems. Collaborate with clinical teams to enhance workflows, ensure compliance, and provide technical support, all while driving cont...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$115K - $130K *

Join a team that's committed to enhancing regulatory compliance through strategic initiatives, robust IT control design, and effective collaboration across business units to ensure adherence to indust...

RemoteRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Real Estate & Construction

$135K - $160K *

Grow your career with a dynamic team focused on enhancing knowledge management. Lead strategic initiatives, develop talent, and shape self-service experiences while collaborating across departments to...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$150K - $230K *

Engineer impactful relationships in oncology by promoting innovative therapies, driving patient access, and exceeding performance goals. Collaborate with stakeholders to enhance care delivery and leve...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$168K - $188K *

Oversee and manage clinical trials from protocol development to final report, ensuring compliance with GCP and regulatory standards. Collaborate with cross-functional teams to enhance research efficie...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$117K - $189K *

Join a team that's shaping the future of pharmaceutical quality by leading compliance initiatives and building a robust Quality Management System to support innovative therapies in a dynamic, collabor...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$125K - $160K *

Elevate your career by owning electrical application engineering for prefabricated platforms. Collaborate across disciplines to deliver scalable solutions, ensuring design integrity and execution read...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$200K - $215K *

Advance the cloud platform capabilities, ensuring secure, reliable, and scalable product delivery while enhancing developer experience and shaping reliability practices in a mission-driven healthcare...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$100K - $110K *

Empower corporate veterinary groups by driving software adoption and growth. Collaborate with cross-functional teams to develop strategic partnerships, influence decisions, and enhance customer satisf...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$185K - $315K *

Elevate your career by providing essential medical expertise in dermatology, fostering relationships with healthcare professionals, and leading scientific dialogue to drive innovative solutions in a f...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Unlock potential by leading sales strategies that drive revenue growth, collaborating with experts to execute impactful cycles, and consistently achieving quotas in a dynamic market focused on health...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Healthcare

$70K - $120K *

Lead transformative Medicaid initiatives by guiding project oversight, ensuring timely execution, and enhancing stakeholder engagement. Collaborate with teams to streamline operations and achieve stra...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$61K - $165K *

Join a team that's dedicated to enhancing CAD systems and engineering data management. Drive best practices, support users, and ensure data integrity while collaborating across departments to optimize...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$63K - $112K *

Join a team that's dedicated to enhancing client relationships and driving sales growth through effective product presentations and customer feedback. Collaborate with marketing and sales staff to ens...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $130K *

Grow your career with a dynamic role that involves conducting in-depth research across various topics, delivering actionable insights, and collaborating with a high-performing team to tackle complex q...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $135K *

Lead the charge in human services policy consulting to enhance operations and compliance for government agencies. Utilize expertise in federal regulations and stakeholder engagement to provide actiona...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$95K - $115K *

Unlock potential by managing and optimizing project-level agreements, ensuring compliance and efficiency in contracting processes while supporting global operations and client needs in a dynamic legal...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Champion patient care by evaluating and managing chronic pain conditions, collaborating with healthcare teams to create tailored treatment plans that enhance quality of life and optimize outcomes for...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$128K - $192K *

The Workday Financials Integrations Senior Principal Consultant - Global AMS is a seasoned professional responsible for leading integration efforts and managing Workday financial services for clients...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.