Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$200K - $232K *

Unlock potential by leading legal reviews for promotional and medical materials. Collaborate across teams to ensure compliance and provide practical guidance in a fast-paced environment, supporting pr...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Shape the future of healthcare by leading regional sales efforts, driving product launch success, and building high-performing teams. Collaborate cross-functionally to achieve sales goals and foster s...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Optimize clinical support for Heart Alert Service by reviewing ECG episodes, ensuring accurate documentation, and collaborating across functions to enhance patient care and workflow efficiency...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$129K - $185K *

Innovate global medical strategies for the Companion Animal Pain portfolio, driving growth and customer value through scientific engagement, KOL collaboration, and effective market implementation acro...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$200K - $230K *

Champion a transformative member software experience, guiding strategy and design across the care journey. Leverage data and user insights to drive impactful solutions in a complex healthcare landscap...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$75K - $105K *

Tackle comprehensive project management for onboarding HME providers, driving digital transformation across healthcare. Collaborate strategically, enhance platform adoption, and leverage data insights...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$135K - $165K *

Drive customer success in Cancer Registry by building relationships, enhancing retention, and translating insights into actionable solutions. Collaborate across teams to improve outcomes and shape bus...

RemoteRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$240K - $330K *

Pioneer growth in the healthcare sector by driving new business and cultivating strong client relationships. Utilize expert sales skills to oversee complex deals from prospecting to closing in a consu...

RemoteRemote

Reposted today

  •   5 - 7 years exp.  •   Enterprise Technology

$75K - $95K *

Shape the future of clinical research data integrity by leading a dedicated team. Drive operational excellence, ensure compliance, and foster cross-functional partnerships to enhance data quality and...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$117K - $155K *

Join a team that's driving IT compliance excellence by executing control-based activities, collaborating with stakeholders, and minimizing risks to support critical compliance objectives across variou...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Business Services

$210K - $263K *

Join a team that's redefining indirect sales strategies by building and scaling reseller and embedded partner programs. Drive significant revenue growth through strategic alliances and cross-functiona...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$139K - $235K *

Drive your career forward by owning SEC reporting and disclosures, coordinating cross-functional processes, and enhancing the quality and efficiency of external financial reporting as a critical membe...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$274K - $371K *

Develop and lead early phase clinical strategies for oncology candidates, ensuring design and execution of clinical trials. Collaborate with internal teams and external experts to drive innovative dru...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Transform cardiovascular care by joining a collaborative outpatient team, focusing on General Cardiology or Electrophysiology. Enjoy a weekday schedule with no call, while enhancing your skills alongs...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$157K - $174K *

Elevate technical execution in GMP manufacturing by leading complex workstreams for comparability strategies, tech transfers, and process improvements. Collaborate with cross-functional teams to ensur...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Join a dedicated team as a Clinical Pharmacist, ensuring safe and effective medication therapy while collaborating with healthcare professionals to enhance patient outcomes and streamline pharmacy ope...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Lead the development and implementation of health policy initiatives that align with organizational goals. Collaborate with stakeholders to influence policy decisions and improve health outcomes at lo...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$70K - $105K *

Collaborate with cross-functional teams to enhance EHR workflows, improve operations, and optimize patient care through effective configuration and analysis of Professional Billing Claims applications...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$180K - $220K *

Unlock your potential by driving enterprise growth in healthcare. Join a dynamic team focused on building relationships with health systems and provider organizations, leveraging a robust support engi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$225K - $265K *

Shape the future of oncology by leading clinical studies in early-phase development. Collaborate with multidisciplinary teams to drive innovative therapies and ensure high-quality execution of clinica...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$106K - $159K *

Transform regulatory strategies by providing CMC expertise to support product development and compliance in a dynamic pharmaceutical environment, ensuring quality and adherence to global standards thr...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$150K *

Lead the charge in driving Medicare partnerships, enhancing contract value, and achieving growth targets through strategic sales initiatives and relationship management with health plans...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$125K - $235K *

Drive operational excellence in healthcare by leading transformative initiatives, optimizing workflows, and enhancing provider productivity. Collaborate with teams to deliver data-driven solutions tha...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$75K - $90K *

Empower patients to achieve optimal physical health by evaluating needs, creating tailored care plans, and delivering effective treatments. Collaborate with a dedicated team to enhance patient outcome...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$135K - $160K *

Champion provider partnerships by leading a dynamic team to drive referrals for interventional treatments across multiple states. Utilize data-driven strategies to enhance performance and build impact...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.