Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Vice President, Payer Sales
$225K - $250K *
Elevate your career by leading payer sales strategy and team development, driving new business opportunities in healthcare technology. Collaborate with executives to enhance performance and deliver im...
2 weeks ago
Physical Medicine and Rehabilitation Medical Director
$206K - $413K *
Join our team to lead in Physical Medicine and Rehabilitation, providing oversight, improving utilization, and guiding medical policy. Collaborate with staff and external partners to enhance healthcar...
Reposted 5 days ago
Executive Director, Field Operations Strategy & Excellence
$246K - $332K *
Transform the future of field operations by leading strategic initiatives that enhance commercial effectiveness and drive measurable impact across customer-facing teams. Collaborate with cross-functio...
1 week ago
$87K - $157K *
Unlock compliance excellence by managing auditing, monitoring, and reporting processes to ensure adherence to regulatory standards and enhance operational efficiency across contracts and collaboration...
1 month ago
National Account Director, Community Oncology
$245K - $290K *
Champion strategic relationships in community oncology to enhance market access for innovative therapies. Drive account strategies, negotiate contracts, and collaborate cross-functionally to ensure op...
3 days ago
Lead Director, Provider Service Model Lead
$100K - $231K *
Join our dynamic Network team to lead complex projects, enhance provider experiences, and drive strategic initiatives. Collaborate with cross-functional teams to optimize network infrastructure and en...
1 week ago
$131K - $182K *
Empower revenue teams by leading a dynamic group of Revenue Enablement Managers. Drive ongoing performance through strategic coaching, hands-on training, and AI-first initiatives, ensuring alignment a...
1 week ago
$152K - $190K *
Drive the future of data analytics by leading a dynamic team to enhance enterprise data strategies, governance, and insights that align with business objectives and foster innovation across the organi...
Today
Executive Director, Strategic Accounts
$246K - $332K *
Transform healthcare by leading national strategic account management efforts. Drive partnerships with key institutions, enhance patient care, and foster cross-functional collaboration to achieve comm...
6 days ago
Associate Director, Project Management
$105K - $120K *
Elevate project management excellence by leading a dynamic team, ensuring high-quality execution across flagship accounts, and driving operational efficiency through strategic oversight and collaborat...
3 weeks ago
$185K - $275K *
Join a team that's driving revenue growth through strategic marketing initiatives. You'll lead regional marketing efforts, develop account-based strategies, and collaborate with sales to optimize pipe...
2 weeks ago
Director, Client Media Solutions
$100K - $140K *
Drive innovative media strategies for healthcare clients, leveraging audience insights and performance data. Collaborate with cross-functional teams to enhance planning processes and deliver impactful...
1 week ago
Director, Head of Project Execution, Digital Technologies
$120K - $145K *
Innovate digital experiences by leading project execution across technology portfolios. Collaborate with business and tech leaders to drive priorities, enhance capabilities, and deliver exceptional me...
2 weeks ago
Director, Supply Chain Operations
$125K - $150K *
Join a dynamic team to optimize supply chain operations, ensuring efficient medication delivery from pharmacy partners to patients. Oversee systems, processes, and a team to scale operations amidst ra...
Reposted 1 week ago
$120K - $150K *
Transform subscription retention strategies to drive growth and revenue. Own metrics, analyze data, and collaborate cross-functionally to enhance customer experience and optimize retention initiatives...
1 week ago
Associate Director, Compliance
$110K - $130K *
Drive the enhancement of Compliance Monitoring and Testing programs, ensuring regulatory alignment and effective risk management. Collaborate with stakeholders to improve operational efficiency and su...
1 week ago
$125K - $150K *
Drive total rewards strategy by managing compensation, benefits, and equity programs. Lead initiatives to ensure competitive, fair, and transparent offerings while supporting a growing workforce throu...
Yesterday
$75K - $112K *
Unlock potential by managing complex billing processes and leading a team to ensure accurate invoicing and exceptional customer service. Collaborate across departments to drive efficiency and implemen...
6 days ago
Senior Director, Innovation and Delivery
$200K - $250K *
Drive critical initiatives by navigating ambiguity, building effective operating models, and ensuring measurable outcomes in a dynamic environment. Engage with leadership to implement AI solutions and...
Reposted 4 weeks ago
$120K - $145K *
Accelerate commercial growth by defining strategies for product families, collaborating across teams to translate market insights into actionable plans that drive revenue, profitability, and customer...
Today
Manager, Complex Clinical Denials
$100K - $120K *
Drive impactful projects by collaborating across teams to enhance operational efficiency and deliver innovative solutions. Leverage your expertise to influence strategic decisions and contribute to a...
2 days ago
Vice President of Transformation and Shared Services
$190K - $200K *
Elevate operational excellence by leading transformation initiatives and optimizing Shared Services. Collaborate with senior leaders to drive measurable improvements in productivity, cost efficiency...
1 week ago
Director, Pricing and Profitability
$124K - $223K *
Shape the future of pricing strategy by leading a dynamic team to optimize profitability and drive strategic decisions across SaaS and services. Collaborate with executives to enhance customer value a...
3 weeks ago
Associate Manager AGI Research
$105K - $124K *
Lead and optimize research intern activities, ensuring alignment with project goals and technical standards. Manage workflows, provide coaching, and conduct hands-on research while supporting the Dire...
Today
Sr Manager, Operational Finance
$135K - $160K *
Advance financial operations by managing project finance teams, enhancing reporting processes, and supporting month-end close activities. Collaborate with stakeholders to ensure accurate revenue recog...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.