Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
VP, Account Management - Carolinas (NC/SC)
$164K - $305K *
Join a team that's redefining account management by driving growth and retention for complex health systems. Build strategic relationships with C-suite executives and lead cross-functional teams to de...
1 week ago
$184K - $254K *
Shape the future of corporate strategy by leading cross-functional teams to develop enterprise-wide strategic plans, drive growth initiatives, and influence senior leadership decisions through data-dr...
2 days ago
$275K - $340K *
Drive growth by leading sales and customer success teams, refining strategies, and optimizing processes. Shape the commercial landscape while mentoring talent and ensuring high-value customer relation...
3 days ago
Clinical Trial Manager II, Dermatology & Rheumatology CRO, USA
$100K - $120K *
Engage with a dynamic CRO to oversee clinical monitoring and enhance site performance. Foster relationships, ensure compliance with regulations, and lead a team in delivering quality outcomes in clini...
Reposted 3 weeks ago
Associate Director, Global Value & Access, Hematology
$153K - $203K *
Drive global access and pricing strategies for hematology assets, ensuring timely reimbursement and optimal patient access. Collaborate with cross-functional teams to develop evidence-based toolkits a...
3 weeks ago
Associate Director, Manufacturing Business Operations & Strategy
$203K - $228K *
Join a dynamic team to lead strategic manufacturing operations, integrating technical and business insights to drive successful commercialization and lifecycle management of biologics and cell therapi...
4 weeks ago
Senior Director, US Marketing, Inborn Errors of Metabolism
$247K - $305K *
Support the strategic commercialization of rare disease therapies by leading marketing initiatives, collaborating cross-functionally, and optimizing brand strategies to enhance patient access and enga...
Reposted yesterday
$110K - $130K *
Join a team that's dedicated to transforming healthcare data solutions. As a Senior Data Engineer, you'll enhance complex systems, collaborate across departments, and drive analytics to optimize finan...
Reposted 2 weeks ago
$110K - $130K *
Contribute to impactful consulting services in government pricing, leveraging your expertise to guide clients through compliance, data analysis, and strategic initiatives while leading a collaborative...
2 days ago
Regional Director - Hematology - Ohio Valley
$212K - $287K *
Transform the Hematology landscape by leading a high-performing sales team, driving strategic initiatives, and ensuring compliance while exceeding sales objectives in the Great Plains region...
2 days ago
Senior Director, Commercial Manufacturing
$180K - $200K *
Champion commercial manufacturing excellence by leading technical operations, ensuring on-time delivery of drug products and APIs, and collaborating with regulatory teams to meet compliance and perfor...
4 weeks ago
Director, Business Applications
$120K - $145K *
Transform the future of business applications by leading strategy, delivery, and operations. Collaborate with multidisciplinary teams to enhance core processes and drive value through effective system...
1 week ago
Director, Field Medical Affairs, West Coast
$160K - $190K *
Champion a national team of Medical Science Liaisons focused on obesity, driving strategy and KOL engagement. Lead cross-functional collaboration and ensure compliance while developing high-performing...
Reposted 2 days ago
IBP & Demand Planning Assoc Director
$145K - $182K *
Drive demand planning excellence by leading the Americas team, collaborating across functions to enhance forecasting accuracy and integrated business planning. Transform scenario planning capabilities...
1 week ago
Director, GLP-1 & Cardiometabolic Product Marketing
$194K - $242K *
Unlock potential by leading product marketing strategies in GLP-1 and cardiometabolic health. Collaborate with cross-functional teams to enhance buyer clarity and sales effectiveness, while coaching a...
6 days ago
Senior Renewal Operations Manager
$104K - $176K *
Elevate customer success by transforming renewal strategies through data-driven insights. Collaborate with cross-functional teams to enhance systems, forecast renewals, and improve retention metrics f...
Reposted 3 weeks ago
$110K - $130K *
Empower business leaders by building financial models and analyses that drive strategic decisions. Collaborate across teams to evaluate opportunities, support fundraising, and present insights to seni...
1 week ago
Process & Technology Specialist
$66K - $128K *
Transform sales operations by owning CRM administration, building dashboards, and automating processes. Collaborate with teams to enhance technology adoption and streamline workflows, ensuring effecti...
Today
Director, AI Platform & Transformation
$218K - $284K *
Empower decision-making by leading enterprise AI strategy, transforming innovative concepts into scalable applications that drive measurable business outcomes across diverse operational areas and enha...
Reposted 5 days ago
Director, R&D Portfolio Program Management
$175K - $220K *
Lead and develop a high-performing R&D project management team, overseeing a diverse portfolio of innovative projects. Drive effective execution while mentoring staff and enhancing cross-business proc...
Reposted 3 days ago
Key Account Director, Majors East
$144K - $200K *
Accelerate public safety initiatives by leading a regional sales team, enhancing team performance, and driving strategic growth in drone technology for emergency response agencies across the U.S...
1 week ago
Director of Services - US West
$150K - $200K *
Engage in leading a dynamic team dedicated to delivering top-notch offensive security engagements, ensuring delivery quality and client satisfaction, while collaborating with sales to expand accounts...
Reposted 3 weeks ago
$130K - $150K *
Drive revenue growth by acquiring new business and managing key accounts, leveraging relationship-building, lead generation, and strategic selling in a fast-paced environment to redefine contractor ri...
Reposted 5 days ago
Manager, Strategic Client Solutions
$100K - $120K *
Accelerate client relationships by managing strategic accounts, driving revenue growth, and expanding service lines. Collaborate with internal teams to ensure client satisfaction and deliver tailored...
3 days ago
$125K - $135K *
Lead the charge in developing and managing enterprise proposals and plans, ensuring compliance and quality across submissions. Collaborate with cross-functional teams to enhance win strategies and dri...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.