Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$160K - $185K *
Unlock your potential by leading a dynamic team to drive channel partnerships, transforming opportunities into revenue-generating relationships across diverse verticals in a fast-growing ecosystem...
1 week ago
Executive Director, Clinical Operations
$285K - $310K *
Lead the strategic execution of global clinical trials, ensuring adherence to timelines, budgets, and quality standards while fostering collaboration across teams and mentoring Clinical Operations per...
6 days ago
Program Specialist, Care Management
$74K - $119K *
Transform healthcare delivery by coordinating strategic programs that enhance clinical and operational excellence. Collaborate with diverse teams to implement innovative solutions, ensuring compliance...
1 week ago
Director, Demand & Supply Planning
$125K - $150K *
Transform Drug Supply Chain Operations by leading cross-functional teams to establish reliable planning cadences and robust processes, ensuring continuous delivery of medication while driving efficien...
Reposted 4 weeks ago
FP&A Controller, Laboratory Solutions
$118K - $162K *
Elevate financial performance by analyzing business trends, preparing forecasts, and driving digital finance initiatives. Collaborate with cross-functional teams to ensure strategic financial success...
1 week ago
Program Manager, Medical Communications
$70K - $105K *
Collaborate with cross-functional teams to drive project execution and operational excellence in medical communications. Leverage your project management skills to ensure timely delivery and high-qual...
1 week ago
Capture & Business Development Manager
$85K - $110K *
Drive business growth by identifying and qualifying federal procurement opportunities, focusing on healthcare contracts. Collaborate on capture strategies and build partnerships to enhance win probabi...
1 week ago
Manager of Clinical Engagement
$115K - $130K *
Join a team that's redefining clinical engagement by leading strategic initiatives to enhance clinician pipelines, improve hiring processes, and foster partnerships across multiple regions, driving or...
4 days ago
Manager, Quality Assurance (LTSS)
$104K - $143K *
Join a dynamic team to lead Quality Assurance efforts in Long-Term Services and Supports. Oversee compliance, collaborate with external partners, and drive operational excellence while ensuring adhere...
1 week ago
Account Director Senior - NeoCloud Enterprise
$139K - $185K *
Lead the charge in driving growth for major enterprise accounts by aligning customer priorities with Lumen's diverse portfolio, ensuring strategic execution from acquisition to expansion while advisin...
4 weeks ago
$180K - $230K *
Grow your career with a leadership role overseeing global operations, focusing on strategy development, performance management, and cross-department collaboration to drive operational excellence and i...
Reposted 1 week ago
$125K - $150K *
Empower strategic financial decisions by analyzing investments, market opportunities, and capital allocation. Collaborate with C-suite executives to drive growth and optimize resource allocation while...
2 weeks ago
Product Manager - Vendor Oversight
$113K - $197K *
Lead the charge in defining product strategy and roadmap, translating business objectives into actionable plans. Collaborate with cross-functional teams to ensure successful implementation and operati...
1 week ago
Director, Market & Network Strategy
$163K - $214K *
Lead the charge in defining strategic market presence and network design. Drive investment decisions by analyzing demand, competition, and demographics to optimize facility configurations across multi...
6 days ago
Associate Director, Social Media
$90K - $115K *
Elevate your career by leading innovative social media programs that connect healthcare clients with their audiences. Drive strategic content development and manage cross-functional teams to ensure im...
Reposted 1 week ago
$98K - $130K *
Transform warehouse and eCommerce operations by leading technical and operational projects. Collaborate with cross-functional teams to design scalable solutions that enhance productivity and drive exc...
1 month ago
Vice President Management Services
$205K - $380K *
Drive transformative supply chain initiatives, providing strategic leadership and operational oversight to enhance efficiency and best practices across client hospitals. Collaborate with C-suite execu...
Yesterday
Executive Director, Technology
$175K - $215K *
Elevate the technology function by leading engineering, delivery, and operations. Collaborate closely with leadership to shape technical strategy, ship code weekly, and ensure high standards in a dyna...
2 weeks ago
Director, Field Sales Engineering
$191K - $239K *
Lead the development and growth of a Sales Engineering team focused on new product incubation, driving adoption and revenue through strategic customer engagements and cross-functional collaboration to...
Reposted 2 weeks ago
Director, Global Commercial Planning and Forecasting
$160K - $190K *
Elevate your career by leading global commercial planning and forecasting efforts. Drive strategic decision-making, optimize supply allocation, and enhance business development through robust analytic...
1 week ago
Manager, Commercial Excellence-Installation Programs
$125K - $171K *
Join a team that's focused on driving financial optimization and transforming commercial strategies. Lead efforts in budget management, contract performance, and risk mitigation while collaborating ac...
4 weeks ago
$160K - $215K *
Elevate business integrity by spearheading internal audits, enhancing risk assessments, and streamlining processes. Collaborate cross-functionally to ensure robust controls, compliance, and effective...
Reposted 3 weeks ago
$192K - $258K *
Join a team that's shaping construction risk management across global projects. Lead efforts in governance, compliance, and audit for data center development while collaborating with key stakeholders...
4 weeks ago
$115K - $130K *
Advance financial operations by leading accounting processes, ensuring compliance, and fostering collaboration across teams. Drive efficiency and support strategic goals while managing a team and enha...
3 weeks ago
Vice President, Value Partnerships DX
$207K - $284K *
Elevate strategic partnerships in the healthcare diagnostics sector, driving innovative solutions and collaboration across teams. Lead high-impact initiatives that align customer needs with Siemens He...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.