Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Quality Operations Manager (Contract)
$100K - $120K *
Contribute to quality operations initiatives by reviewing study documents, supporting audits, and ensuring compliance with regulatory standards. Collaborate with cross-functional teams to enhance qual...
4 days ago
$195K - $217K *
Drive client success by leading strategic initiatives and fostering strong relationships in healthcare technology. Leverage deep domain expertise to enhance outcomes and ensure effective use of soluti...
1 week ago
$150K - $180K *
Join a dynamic team as a finance leader, driving strategic growth through financial planning, investment analysis, and operational excellence. Collaborate with executives to shape business performance...
4 weeks ago
$115K - $175K *
Advance market share by driving strategic growth initiatives within the US Mid-Market and Enterprise carrier segments. Lead a high-performing team to execute regional plans, leveraging deep telecom ex...
Today
Manager, Procurement Compliance, Governance and Data & Analytics
$110K - $172K *
Shape global procurement governance and compliance by leading analytics, training, and process excellence initiatives. Drive transformation and data management in a collaborative environment to enhanc...
1 week ago
Associate Director - Clinical Operations - Healthcare
$155K - $259K *
Transform healthcare performance by leading integrated optimization programs that enhance clinical, operational, and financial outcomes for hospitals and health systems. Drive measurable results throu...
3 days ago
$178K - $245K *
Drive end-to-end digital transformation for enterprise supply chains, managing high-stake programs while leading cross-functional teams. Ensure delivery excellence, foster client relationships, and op...
4 weeks ago
$115K - $192K *
Engineer trusted, reusable data products by transforming architectural designs and business requirements into production-grade solutions. Collaborate with cross-functional teams to deliver innovative...
1 week ago
Director, Sales – Global Strategic Accounts
$150K - $180K *
Empower a high-performing sales team to drive strategic growth and customer engagement in the biopharma sector. Lead complex sales initiatives, build executive relationships, and translate business st...
Yesterday
National Accounts Lead Director, Clinical Program Consultant (CPC)
$100K - $231K *
Transform healthcare outcomes by leading a team of Clinical Program Consultants to analyze data, optimize clinical programs, and drive strategic initiatives that enhance customer health and reduce cos...
Today
SDLC & ADLC Governance Lead (Remote)
$108K - $130K *
Grow enterprise software and AI delivery governance by defining standards, enhancing processes, and ensuring compliance. Lead the development of frameworks for traditional and AI solutions, driving co...
3 weeks ago
Regional Vice President, Health Plan Growth
$180K - $215K *
Empower strategic growth by managing health plan partnerships, driving revenue, and enhancing client relationships. Utilize your expertise in managed care to deliver impactful solutions and ensure cli...
3 weeks ago
Executive Director, Account Management
$255K - $310K *
Lead a high-performing team to execute market access strategies, optimize payer engagement, and enhance product positioning. Drive collaboration across stakeholders to ensure effective reimbursement a...
6 days ago
VP, Data Strategy & Governance
$180K - $220K *
Drive the enterprise data strategy and governance, ensuring data quality, compliance, and accessibility. Lead cross-functional teams to foster a data-rich culture, enabling advanced analytics and AI r...
Reposted yesterday
$80K - $95K *
Drive customer satisfaction and growth by nurturing relationships, identifying upsell opportunities, and collaborating on account strategies. Leverage industry insights to maximize account potential a...
4 weeks ago
Sr. Analyst, Health System Pharmacy Financial Performance
$85K - $104K *
Champion financial performance analysis for specialty pharmacy, collaborating with cross-functional teams to enhance revenue integrity and profitability through actionable insights and strategic recom...
2 days ago
Manager, Workday Financial Systems and Innovation
$104K - $140K *
Transform financial systems by leading a high-performing team to enhance Workday Financials, ensuring operational excellence and strategic alignment with business goals while driving continuous improv...
2 weeks ago
$90K - $100K *
Transform project management by leading client-sponsored trials, coordinating multidisciplinary teams, and ensuring timely delivery of objectives while fostering collaboration and communication across...
Yesterday
Senior Manager, Clinical Operations
$136K - $171K *
Pioneer clinical trial excellence by leading operational planning and execution. Collaborate cross-functionally to ensure compliance, quality, and timely delivery of clinical studies while mentoring j...
1 week ago
$190K - $230K *
Join a team that's driving innovation in biopharma partnerships. Leverage your expertise to identify and advance strategic opportunities, influence cross-functional decisions, and manage alliances tha...
6 days ago
VP, Operations (Digital Solutions) - Remote
$134K - $215K *
Empower our team by leading operational solutions and client services. Drive strategic initiatives, enhance product delivery, and ensure exceptional quality across digital platforms while collaboratin...
Yesterday
$100K - $120K *
Lead the monthly close and day-to-day accounting operations, ensuring accuracy and efficiency as the business scales. Collaborate with cross-functional teams to enhance processes and implement automat...
3 days ago
Director, Managed Markets - Regional - Central
$235K - $270K *
Drive your career forward by leading access strategies across the Central region. Manage key payer relationships and ensure launch readiness for rare disease products while collaborating with cross-fu...
2 weeks ago
Director, Chronic Practice Liaison - Remote
$126K - $210K *
Lead strategic initiatives to enhance referral growth and provider engagement across chronic therapy markets. Drive collaboration among cross-functional teams to optimize patient progression and deliv...
3 weeks ago
Director, QMS Process Owner - Global Change Control Management
$168K - $228K *
Transform global GxP Change Management processes by leading strategy, governance, and continuous improvement initiatives across the product lifecycle, ensuring effective risk-based changes and collabo...
Yesterday
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.