Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.
Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.
Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.
Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.
Project Director, Dermatology and Rheumatology, CRO, US, remote USA
$125K - $150K *
Oversee a portfolio of clinical studies, ensuring compliance and quality. Lead Project Managers in executing complex trials, driving operational efficiency and client satisfaction while leveraging you...
2 weeks ago
Director, Integrated Marketing
$130K - $160K *
Join a dynamic team to drive integrated marketing strategies that enhance brand visibility and support business growth through innovative campaigns, digital activation, and thought leadership across m...
2 weeks ago
Director of Human Resources & Risk Management
$115K - $125K *
Drive comprehensive HR and risk strategies, overseeing talent management, compliance, and workplace safety while ensuring alignment with organizational values and regulations across multiple campuses...
4 weeks ago
Assistant Director, Supervision
$127K - $171K *
Lead a dynamic team in overseeing compliance and supervision for securities and investment advisers. Drive risk mitigation strategies, enhance supervisory frameworks, and collaborate with cross-functi...
3 days ago
Senior Reward & Mobility Manager
$180K - $200K *
Accelerate progress at a multinational level by driving the reward and global mobility agenda. Lead the design and governance of compensation structures, ensuring alignment with business needs while p...
Reposted 1 week ago
$206K - $309K *
Elevate the Analyst Experience by owning strategy and outcomes for security workflows. Lead a team of product managers to unify analyst tools, drive customer migrations, and enhance product vision, en...
Yesterday
Senior Manager Tax Technology and Process Transformation
$126K - $150K *
Pioneer the transformation of tax technology and processes, driving strategic initiatives to enhance operational efficiency, compliance, and user experience through automation and data-driven solution...
3 weeks ago
$170K - $180K *
Transform the sales landscape by leading strategic initiatives that enhance performance management, forecasting, and accountability across the commercial organization, driving profitable growth and ac...
3 weeks ago
$110K - $130K *
Drive growth by building and scaling credit card acquisition channels through innovative affiliate partnerships, targeted paid search, and social programs, while collaborating with cross-functional te...
2 days ago
Senior Engineering Manager, Agent Platform & Growth
$150K - $180K *
Join a team that's redefining the onboarding experience for human and AI agents by leading innovative UX and engineering teams. Drive growth through strategic roadmap ownership, hands-on leadership, a...
Reposted 4 weeks ago
$150K - $180K *
Manage financial planning and performance analysis for the GTM organization, partnering with leadership across Sales, Marketing, and Customer Success to drive revenue growth and profitability through...
4 weeks ago
Program Manager Onboarding - Human Resources
$88K - $105K *
Join a team that's redefining onboarding by creating a scalable, engaging experience for new hires. Lead the design and execution of programs that enhance integration, retention, and productivity acro...
2 weeks ago
$125K - $150K *
Unlock potential by driving client success through expert system configuration, data analysis, and consultative training. Ensure timely project delivery while enhancing user experience and satisfactio...
Reposted 3 weeks ago
Senior Advisor, Sponsored Projects & Funds
$135K - $145K *
Advance your career by leading strategic partnerships and managing fiscal sponsorship projects. Collaborate with clients and stakeholders to ensure successful outcomes while providing expert guidance...
3 weeks ago
Director, Digital Tech Transfer & Knowledge Management
$173K - $272K *
Lead the charge in shaping digital tech transfer and knowledge management strategies. Drive execution with a multi-disciplinary team to enhance manufacturing capabilities and ensure seamless integrati...
6 days ago
Director, Emergency Services-(UPMC Harrisburg)
$110K - $130K *
Join a team that's dedicated to enhancing emergency services by optimizing clinical operations, improving patient care delivery, and fostering a culture of collaboration and innovation within a dynami...
2 days ago
$150K - $180K *
Join a team that's redefining scientific data management in drug discovery. Lead the scientific data team, bridging scientists and engineers to ensure data integrity, quality, and innovative solutions...
3 weeks ago
$80K - $95K *
Take ownership of payroll operations, ensuring accuracy and compliance while leading a team to deliver timely wage payments and manage tax obligations effectively across the organization...
6 days ago
$80K - $95K *
Drive clinical excellence as you lead a team of BCBAs and RBTs, overseeing daily operations and ensuring high-quality ABA therapy through collaboration, supervision, and training. Make a meaningful im...
1 month ago
$120K - $140K *
Shape the future of federal financial operations by driving user adoption and change management for a new tool. Collaborate with stakeholders to enhance user experience, streamline processes, and ensu...
1 week ago
$70K - $140K *
Lead the charge in enhancing our Partner ecosystem by managing relationships and driving growth initiatives. Oversee onboarding, operations, and support for System Integrators while implementing autom...
Reposted 3 weeks ago
$125K - $174K *
Drive product design and cross-functional initiatives, ensuring alignment across teams. Build reporting tools for product visibility, resolve customer escalations, and translate feedback into actionab...
3 weeks ago
Sr. Director, Scientific Affairs
$181K - $225K *
Lead the charge in operationalizing complex clinical studies globally, collaborating with cross-functional teams to enhance proposal development and manage global lab relationships, ensuring strategic...
3 weeks ago
Sr. Director, Scientific Affairs
$181K - $225K *
Lead the charge in advancing scientific operations within a dynamic team, driving global lab relationships and supporting complex clinical studies. Collaborate across functions to ensure strategic, op...
3 weeks ago
$100K - $150K *
Shape impactful health initiatives by providing expert project management support to the CDC's Office of the Director, ensuring effective prioritization, coordination, and execution of programs in a d...
Yesterday
What types of $100K+ jobs can I find in Pennsylvania?
Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.
Which Pennsylvania cities have professional job opportunities?
Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.
Are these Pennsylvania jobs vetted?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.
Can I find remote or hybrid jobs in Pennsylvania?
Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.