Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$125K - $150K *

Take ownership of project controls for a large-scale aviation construction project, leading cost management, scheduling, and risk assessment. Collaborate with stakeholders to ensure project success wh...

3 weeks ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$95K - $125K *

Drive the deployment of healthcare technology across multiple VA facilities, coordinating projects and ensuring readiness. Collaborate with diverse teams to manage timelines, resolve issues, and deliv...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $175K *

Lead complex automation projects from proposal to closeout, ensuring predictable outcomes across scope, schedule, cost, quality, and safety while managing technical and commercial risks in a collabora...

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $180K *

Accelerate your career by leading CRM product management, shaping the roadmap for Salesforce solutions, and driving innovation in AI integration while collaborating with cross-functional teams to enha...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Drive project delivery excellence by architecting frameworks, managing resources, and synchronizing teams. Lead cross-functional initiatives, optimize processes, and mentor project managers to ensure...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Food & Beverages

$130K - $150K *

Optimize complex Salesforce implementations by leading cross-functional teams, managing project lifecycles, and ensuring successful client outcomes through effective communication and risk management...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$115K - $158K *

Drive enterprise transformation initiatives by leading cross-functional teams, managing risks, and aligning strategies with executive leadership to ensure successful project delivery and organizationa...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$160K - $180K *

Lead the charge in driving agile execution across product and engineering teams, managing digital product launches and enhancing client value through innovative solutions. Collaborate cross-functional...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$88K - $105K *

Transform project outcomes by effectively managing timelines, budgets, and resources. Collaborate with teams to ensure successful completion of construction projects while maintaining high standards o...

Today

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$125K - $150K *

Lead preconstruction services for complex projects, ensuring alignment with client goals and excellence. Oversee budgeting, estimating, and risk management while mentoring teams to deliver high-qualit...

1 week ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$110K - $130K *

Join a team that's dedicated to enhancing healthcare reporting through Epic tools. Collaborate with stakeholders to gather requirements, design reports, and provide support, ensuring successful projec...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Empower organizational transformation by leading change management initiatives that drive strategic adoption and enhance employee engagement. Collaborate with leaders to ensure seamless transitions an...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Healthcare

$88K - $105K *

Drive project success by leading self-perform scopes from preconstruction to closeout. Collaborate with teams to ensure quality, safety, and productivity while managing budgets and schedules for optim...

1 month ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$80K - $140K *

Manage and lead construction projects, ensuring quality delivery and profitability. Collaborate across departments, develop teams, and foster customer relationships while upholding ethical standards a...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$190K - $210K *

Transform the contract management landscape for large-scale data center projects. Oversee RFx processes, negotiate contracts, and ensure compliance while collaborating with cross-functional teams to m...

RemoteRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Information Technology

$165K - $237K *

Lead the charge in managing and optimizing global financial systems, ensuring seamless integration and governance across applications. Drive strategic initiatives and collaborate with cross-functional...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Healthcare

$80K - $95K *

Lead software development projects to enhance operational systems, ensuring alignment with user needs and business goals. Collaborate with stakeholders to define product vision, manage QA processes, a...

Today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$145K - $193K *

Join a high-impact team as you lead and coach TPMs and RTEs, ensuring successful technical program delivery and Agile execution across complex projects, while fostering collaboration and continuous im...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$80K - $95K *

Shape customer success by managing project timelines and expectations, fostering relationships, and ensuring accurate forecasting and billing. Drive operational excellence and continuous improvement t...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$211K - $264K *

Transform learning experiences by leading the strategy and operations of our enterprise learning technology ecosystem, ensuring effective governance and seamless integration across platforms to enhanc...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$78K - $100K *

Lead the end-to-end program management for enterprise clients in financial services, driving alignment and execution across cross-functional teams to achieve measurable business outcomes and ensure se...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Media

$110K - $130K *

Join a team that's dedicated to delivering innovative eDiscovery solutions. Collaborate with cross-functional teams to manage client relationships, oversee project execution, and provide expert guidan...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$80K - $95K *

Transform electrical construction projects by managing timelines, budgets, and team dynamics. Collaborate with leadership and clients to ensure quality and safety standards are met while fostering a c...

Today

  •   Less than 5 years exp.  •   Energy & Utilities

$100K *

Join a team that's managing environmental projects, ensuring quality and compliance while mentoring junior staff and driving business development efforts in the oil and gas sector...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Technical Services

$110K - $130K *

Take ownership of complex engineering projects, ensuring timely completion, budget adherence, and client satisfaction while leading teams and managing resources effectively throughout all project phas...

Yesterday

  •   8 - 10 years exp.  •   Technical Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.