Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$80K - $95K *
Shape the future of neurodiverse care by leading clinical services and programming for youth with developmental differences, ensuring high standards and collaborative practices across inpatient and re...
1 week ago
$95K - $115K *
Empower success by managing demand planning processes, analyzing sales data, and collaborating with cross-functional teams to ensure timely customer delivery while minimizing inventory costs and enhan...
3 weeks ago
Director, Technology Partner Architecture Solutions – Legal
$157K - $292K *
Elevate legal technology solutions by leading architecture design and integration with partners. Collaborate across teams to ensure scalable, secure offerings that meet customer needs while guiding a...
2 weeks ago
Area Director, Electrophysiology & Structural Heart-West
$176K - $243K *
Unlock potential by driving the adoption of advanced electrophysiology solutions through strategic partnerships, enhancing customer engagement, and fostering relationships with key stakeholders to ens...
1 week ago
Director, Business Development
$312K - $446K *
Lead a high-performing team to drive strategic growth in defense and intelligence markets. Oversee opportunity identification, partner engagement, and pipeline development, ensuring disciplined execut...
2 days ago
$88K - $105K *
Champion project success by leading controls activities for facility projects, aligning schedules, and ensuring compliance with scope and standards to optimize capital project execution across the org...
Reposted 1 week ago
Managing Principal Consultant - Distribution
$125K - $150K *
Join a dynamic team to lead distribution consulting initiatives, drive operational excellence, and mentor engineers. Shape industry standards as the primary expert in distribution planning while foste...
2 weeks ago
Director, Information Security
$150K - $175K *
Lead the charge in managing client-facing security operations, overseeing a high-performing team, and acting as a trusted advisor. Drive incident response, tool management, and process improvement to...
3 weeks ago
Senior Executive Talent Partner
$111K - $207K *
Empower growth by shaping executive talent strategies that drive success. Partner with senior leaders to enhance recruitment processes, develop talent pipelines, and advise on market trends, while ens...
Reposted 2 weeks ago
Director, Platform Architecture
$317K - $475K *
Join a team that's shaping the future of contact center solutions. Lead a global team, engage with enterprise customers, and drive technical strategy while delivering innovative solutions that address...
Reposted 3 weeks ago
Associate Director, Client Media Solutions
$100K - $115K *
Champion integrated media strategies for pharmaceutical clients, driving engagement and measurable outcomes. Lead cross-functional teams to develop innovative solutions that address complex healthcare...
4 days ago
Associate Director, Client Media Solutions
$95K - $120K *
Accelerate progress at the intersection of media and healthcare by leading integrated planning and strategy for pharmaceutical clients. Drive impactful engagement initiatives while mentoring a talente...
2 weeks ago
$103K - $242K *
Lead the charge in developing strategic compensation frameworks that drive business success. Oversee team management and ensure data integrity while influencing key operational plans and contributing...
Yesterday
Lead Engineer, Order Management
$150K - $186K *
Champion the design and implementation of scalable order management systems, driving technical excellence and collaboration across teams to enhance client trust and operational efficiency in a dynamic...
4 days ago
Start-Up Operations Manager, DTC Launch
$110K - $130K *
Optimize operations in high-volume e-commerce fulfillment centers by leading teams, validating system capabilities, and establishing efficient workflows to drive scalable and successful launch initiat...
Reposted 3 weeks ago
Staff Program Manager, CX Operations & Programs
$131K - $190K *
Lead strategic initiatives that enhance customer engagement and drive actionable insights. Collaborate cross-functionally to improve processes, connect feedback to decisions, and advance customer expe...
2 weeks ago
$110K - $130K *
Advance your career by enhancing the efficiency and effectiveness of our Legal and Compliance function. Lead operational improvements, manage budgets, and implement legal technology solutions in a dyn...
3 weeks ago
Staff/Senior Staff Technical Program Manager, Federal
$220K - $260K *
Lead technical program execution for federal and national security initiatives, transforming partner requirements into secure deployments. Collaborate with engineering teams to ensure operational succ...
Today
Enterprise Principal Architect
$150K - $180K *
Elevate your career by guiding the architecture of cutting-edge enterprise systems, providing strategic technical direction and mentoring teams on best practices across .NET, Azure, and SQL Server to...
Reposted 2 weeks ago
Sr. Engineering Manager - Transportation
$120K - $145K *
Unlock potential by leading engineering teams in transportation projects, ensuring quality control and client satisfaction while mentoring staff and managing budgets across diverse local and national...
Today
$160K - $180K *
Drive innovation as a Senior Product Manager, leading strategic initiatives in Adaptive Training and Continuous Learning. Collaborate with cross-functional teams to enhance user experiences and achiev...
1 week ago
Principal Product Manager, Design Systems & Accessibility
$173K - $290K *
Lead product strategy for design systems and accessibility, driving innovation and adoption across teams. Shape integrated roadmaps, enhance product health, and ensure alignment with evolving AI-nativ...
4 weeks ago
BIM Associate Director - Electrical Focus
$105K - $150K *
Join a team that's at the forefront of digital design as you lead strategic BIM operations across multiple disciplines. Drive collaboration, quality assurance, and innovation while mentoring teams to...
Reposted yesterday
$150K - $180K *
Shape the future of customer experience by leading AI-driven delivery initiatives. Manage a diverse portfolio, ensuring measurable outcomes while guiding teams through complex transformations and fost...
3 weeks ago
Engineering Manager - Member Experience
$179K - $224K *
Join a team that's dedicated to delivering high-quality member-facing systems. As an Engineering Manager, you'll lead a squad through the entire development lifecycle, ensuring accountability, quality...
4 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.