Director, Clinical Operations Jobs

Explore Director, Clinical Operations opportunities for experienced leaders who guide the planning and delivery of clinical research. These roles oversee teams, processes, budgets, and vendor relationships to help clinical trials run efficiently while meeting quality, regulatory, and business goals. Ladders features vetted professional jobs with salaries of $100,000 or more.

What Does a Director of Clinical Operations Do?

Directors of Clinical Operations shape operational strategy across clinical programs and studies. They may lead study planning and execution, manage clinical operations teams, monitor timelines and budgets, oversee CRO and site partnerships, and establish processes for consistent trial delivery. The scope varies by employer, therapeutic area, and organization size.

Qualifications and Skills

Employers commonly seek substantial clinical research experience, a record of leading teams or complex studies, and a strong understanding of clinical trial operations and applicable regulations. Relevant strengths can include project and portfolio management, budget oversight, risk assessment, vendor management, communication, and the ability to collaborate across clinical, medical, regulatory, data, and quality teams. Requirements differ by role; some positions prefer an advanced degree or therapeutic-area expertise.

Career Opportunities and Work Settings

Director-level clinical operations professionals work at biotechnology and pharmaceutical companies, contract research organizations, medical device firms, and other research organizations. Depending on the role, responsibilities may span a single study, a regional team, or a broad clinical development portfolio. Search current openings to compare leadership scope, work arrangements, and employer needs.

Find Director, Clinical Operations Jobs on Ladders

Use Ladders to discover vetted Director, Clinical Operations jobs paying $100,000 or more. Review role requirements and compensation details, then identify opportunities aligned with your clinical research leadership experience and career goals.

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$225K - $300K *

Lead the charge in transforming healthcare operations by driving strategic initiatives, enhancing service excellence, and fostering collaboration across teams to achieve outstanding patient outcomes a...

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$165K - $170K *

Lead process development initiatives to optimize and scale robust manufacturing processes for solid oral dosage forms, ensuring compliance and efficiency while mentoring junior staff and collaborating...

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$167K - $285K *

Architect the future of commercial operations by leading data-driven strategies, forecasting excellence, and innovative automation initiatives. Join us to empower teams with actionable insights and bu...

Reposted today

  •   8 - 10 years exp.  •   Healthcare

$150K - $180K *

Join a team that's redefining scientific data management in drug discovery. Lead the scientific data team, bridging scientists and engineers to ensure data integrity, quality, and innovative solutions...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$121K - $165K *

Shape the future of patient access by developing strategies for CIRM-funded therapies. Collaborate across teams to enhance clinical trial accessibility and market access, ensuring equitable treatment...

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $130K *

Lead the charge in optimizing Wound Care Centers by managing clinical, operational, and financial elements to enhance patient care and drive business growth, ensuring compliance and exceptional experi...

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $130K *

Empower growth by leading operational excellence in wound care centers, ensuring high-quality patient experiences and financial performance while fostering a collaborative team culture aligned with st...

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $130K *

Lead and optimize operations across multiple Wound Care Centers, ensuring exceptional patient experiences and financial performance while driving strategic growth initiatives in alignment with company...

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $130K *

Lead the operational success of Wound Care Centers by managing clinical, financial, and operational elements. Drive business growth and ensure exceptional patient experiences through strategic leaders...

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$158K - $216K *

Shape the future of regulatory strategies through project leadership, ensuring compliance and optimizing processes in collaboration with cross-functional teams and regulatory authorities for successfu...

1 month ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$108K - $130K *

Lead the charge in optimizing clinical operations to enhance patient outcomes, satisfaction, and cost efficiency. Collaborate across departments to establish best practices and drive performance impro...

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $150K *

Lead the charge in driving strategic initiatives within the health system portfolio. Collaborate with executives to shape priorities, utilize data for decision-making, and manage complex cross-functio...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Unlock potential by enhancing marketing operations and driving efficiency across teams. Collaborate closely with leadership to identify process improvements, analyze performance data, and streamline w...

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$126K - $189K *

Join a team that's leading provider enrollment operations, ensuring timely onboarding, compliance, and accuracy. Drive strategic initiatives and enhance operational efficiency across networks while co...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$174K - $374K *

Lead the Medicare Appeals team, overseeing daily operations and ensuring compliance. Collaborate with healthcare professionals to enhance efficiency and provide expert guidance on Medicare policies wh...

Connecticut, USRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Champion client relationships and optimize pharmaceutical distribution projects, leveraging extensive industry expertise to deliver high-quality solutions and insights while managing multiple accounts...

Florida, USRemote

Today

  •   8 - 10 years exp.  •   Media

$118K - $158K *

Transform the CEO's office by driving strategic initiatives, managing executive priorities, and fostering cross-functional collaboration. Leverage your expertise to enhance decision-making and operati...

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$165K - $205K *

Transform centralized revenue cycle operations by leading multiple teams, ensuring quality service delivery, compliance, and financial performance while driving continuous improvement and automation a...

1 week ago

  •   11 - 15 years exp.  •   Healthcare

$103K - $137K *

Join a team that's dedicated to ensuring quality and compliance in patient safety reporting. This role involves reviewing clinical trial safety data, supporting regulatory submissions, and leading pro...

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$107K - $199K *

Join a team that's driving strategic initiatives and operational excellence. This role collaborates with senior leadership to enhance growth plans, manage impactful projects, and ensure alignment acro...

Oregon, USRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$210K - $331K *

Join a team that's shaping the future of gynecologic oncology through strategic Clinical Science leadership, overseeing multiple studies and programs while driving scientific excellence and collaborat...

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$210K - $331K *

Lead the charge in advancing Clinical Science strategies for Gynecologic Oncology, overseeing multiple studies and programs. Collaborate with cross-functional teams to ensure scientific consistency an...

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$275K - $345K *

Elevate clinical pharmacology strategy across oncology trials, leading cross-functional teams to optimize dose selection, regulatory submissions, and DMPK oversight while building a high-performing in...

Today

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$169K - $219K *

Lead the charge in managing a high-performing team to drive customer success, retention, and growth within a dedicated portfolio. Oversee strategic initiatives, operational excellence, and executive p...

Toronto, ONIn-Person

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$148K - $232K *

Empower operational excellence by leading diverse clinical programs, ensuring quality services, and fostering a healthy work environment. Collaborate with clinical leadership to implement strategic po...

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

Frequently Asked Questions (FAQ)

  • What does a Director of Clinical Operations do?question toggle

    A Director of Clinical Operations leads the planning and execution of clinical research operations. Responsibilities may include managing teams, study timelines and budgets, site and vendor relationships, operational processes, and compliance with applicable requirements.

  • What qualifications are typically required for Director, Clinical Operations jobs?question toggle

    Employers generally look for significant clinical research experience and demonstrated leadership in clinical trial operations. Knowledge of trial regulations, project management, budgeting, vendor oversight, and cross-functional collaboration is often valuable. Specific education and experience requirements vary.

  • Where do Directors of Clinical Operations work?question toggle

    They may work for pharmaceutical and biotechnology companies, contract research organizations, medical device firms, and other organizations conducting clinical research.

  • How much do Director, Clinical Operations jobs pay?question toggle

    Compensation varies by employer, location, experience, and role scope. Ladders focuses on vetted professional opportunities paying $100,000 or more; check each listing for its stated compensation and details.

  • How can I find Director, Clinical Operations jobs?question toggle

    Browse current listings on Ladders and compare job responsibilities, qualifications, work arrangements, and compensation to find roles that match your experience and career goals.