Director, Clinical Operations Jobs

Explore Director, Clinical Operations opportunities for experienced leaders who guide the planning and delivery of clinical research. These roles oversee teams, processes, budgets, and vendor relationships to help clinical trials run efficiently while meeting quality, regulatory, and business goals. Ladders features vetted professional jobs with salaries of $100,000 or more.

What Does a Director of Clinical Operations Do?

Directors of Clinical Operations shape operational strategy across clinical programs and studies. They may lead study planning and execution, manage clinical operations teams, monitor timelines and budgets, oversee CRO and site partnerships, and establish processes for consistent trial delivery. The scope varies by employer, therapeutic area, and organization size.

Qualifications and Skills

Employers commonly seek substantial clinical research experience, a record of leading teams or complex studies, and a strong understanding of clinical trial operations and applicable regulations. Relevant strengths can include project and portfolio management, budget oversight, risk assessment, vendor management, communication, and the ability to collaborate across clinical, medical, regulatory, data, and quality teams. Requirements differ by role; some positions prefer an advanced degree or therapeutic-area expertise.

Career Opportunities and Work Settings

Director-level clinical operations professionals work at biotechnology and pharmaceutical companies, contract research organizations, medical device firms, and other research organizations. Depending on the role, responsibilities may span a single study, a regional team, or a broad clinical development portfolio. Search current openings to compare leadership scope, work arrangements, and employer needs.

Find Director, Clinical Operations Jobs on Ladders

Use Ladders to discover vetted Director, Clinical Operations jobs paying $100,000 or more. Review role requirements and compensation details, then identify opportunities aligned with your clinical research leadership experience and career goals.

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$180K - $225K *

Lead client experience strategy and team performance, driving financial success and long-term retention across a diverse account portfolio while collaborating with executive stakeholders to implement...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $150K *

Join a team that's driving HEDIS performance across all business lines, enhancing quality outcomes and operational effectiveness. Lead strategic initiatives, oversee cross-functional collaboration, an...

Harrisburg, PARemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Unlock your potential by leading innovative clinical studies in respiratory disease. Collaborate globally to shape strategies that enhance patient outcomes and drive drug development forward. Join a m...

Mississauga, ONRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$115K - $192K *

Elevate operational excellence by leading process design and transformation initiatives. Drive automation, quality management, and continuous improvement to enhance client data operations and ensure s...

RemoteRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$75K - $145K *

Empower our leadership team by managing complex operations and enhancing productivity. Collaborate across diverse teams to support high-priority initiatives at the intersection of AI and national secu...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$108K - $162K *

Join a team that's dedicated to enhancing biomedical service operations. Lead a skilled team of technicians, ensuring high-quality support and customer satisfaction across the Pacific Northwest while...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Business Services

$125K - $150K *

Optimize transformation readiness by leading enterprise testing strategies. Collaborate with key stakeholders to ensure business solutions meet operational needs, minimize risks, and validate readines...

RemoteRemote

4 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Transform eDiscovery management by driving operational excellence, ensuring timely project delivery, and enhancing workflow efficiency. Collaborate with stakeholders to uphold quality standards and fo...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$175K - $210K *

Lead evidence generation and scientific communications to support innovative gene therapy initiatives. Collaborate with cross-functional teams to identify evidence gaps and execute strategic plans, en...

New York, NYRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$172K - $203K *

Empower the distribution strategy by designing and managing rate content across channels, ensuring accurate delivery and partner trust. Collaborate with cross-functional teams to build scalable progra...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $90K *

Unlock potential by driving departmental success through strategic operations, staff guidance, and performance monitoring. Foster interdepartmental relationships to achieve financial and operational e...

Orlando, FLRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$163K - $224K *

Join a team that's redefining People Operations by leading global service delivery, enhancing employee experiences, and driving operational excellence across Talent Acquisition and People processes fo...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$227K - $313K *

Elevate your career by leading strategic reimbursement initiatives, optimizing revenue cycles, and collaborating with key stakeholders to enhance patient access and billing processes in a dynamic heal...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$229K - $310K *

Drive project management and business development to enhance operational efficiency in life sciences R&D, while leading diverse teams and ensuring profitability through strategic customer engagement a...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Join a dynamic team to develop and deliver clinical training programs, ensuring high-quality education for partners and stakeholders. Act as a subject-matter expert while fostering relationships to en...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$235K - $329K *

Lead clinical pharmacology initiatives, overseeing drug development across infectious disease and oncology programs. Collaborate with cross-functional teams to drive strategic advancements and ensure...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Drive impactful clinical consulting by bridging expertise in real-world data with strategic insights. Collaborate across teams to enhance health outcomes research and contribute to thought leadership...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$237K - $296K *

Join a team that's driving innovation in oncology by leading clinical development and medical affairs. Collaborate across functions to advance pivotal programs and ensure operational excellence in a f...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Drive impactful change by optimizing product operations through collaborative process design, ensuring alignment and efficiency while fostering innovation and simplification across complex product tea...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Food & Beverages

$110K - $130K *

Transform talent acquisition by leading strategic initiatives that foster growth. Develop and optimize recruitment processes while creating a culture of inclusion and innovation to attract top talent...

Atlanta, GARemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$140K - $197K *

Lead the charge in managing strategic client relationships and projects, leveraging your extensive cost management expertise in the data centre sector. Empower teams through mentorship while driving b...

Birmingham, ALRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$176K - $294K *

Engage with healthcare professionals to deliver medical expertise and insights in oncology. Drive strategic initiatives, foster collaboration, and enhance patient-centric communications across diverse...

RemoteRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$162K - $292K *

Join a team that's redefining identity operations by leading a 24/7 team to enhance access management strategies. You'll shape the vision, drive process innovation, and foster talent in a collaborativ...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$225K - $275K *

Drive transformative healthcare consulting initiatives, leading engagement teams to enhance client outcomes through innovative strategies and strong leadership. Shape the future of patient experience...

Chicago, ILRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Business Services

$167K - $183K *

Lead the charge in optimizing G&A technology solutions, enhancing business processes through AI and automation. Collaborate with stakeholders to drive efficiency and compliance, ensuring scalable grow...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What does a Director of Clinical Operations do?question toggle

    A Director of Clinical Operations leads the planning and execution of clinical research operations. Responsibilities may include managing teams, study timelines and budgets, site and vendor relationships, operational processes, and compliance with applicable requirements.

  • What qualifications are typically required for Director, Clinical Operations jobs?question toggle

    Employers generally look for significant clinical research experience and demonstrated leadership in clinical trial operations. Knowledge of trial regulations, project management, budgeting, vendor oversight, and cross-functional collaboration is often valuable. Specific education and experience requirements vary.

  • Where do Directors of Clinical Operations work?question toggle

    They may work for pharmaceutical and biotechnology companies, contract research organizations, medical device firms, and other organizations conducting clinical research.

  • How much do Director, Clinical Operations jobs pay?question toggle

    Compensation varies by employer, location, experience, and role scope. Ladders focuses on vetted professional opportunities paying $100,000 or more; check each listing for its stated compensation and details.

  • How can I find Director, Clinical Operations jobs?question toggle

    Browse current listings on Ladders and compare job responsibilities, qualifications, work arrangements, and compensation to find roles that match your experience and career goals.