Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Clinical Application Specialist - DCAR
$92K - $138K *
Join a dynamic team to deliver clinical education and support for diagnostic cardiology solutions, enhancing customer experience and driving successful outcomes through expert training and collaborati...
Yesterday
Associate General Counsel - Clinical & Commercial - CRO Services
$170K - $200K *
Unlock potential by providing strategic legal counsel on clinical and commercial operations, focusing on regulatory compliance, privacy, and data protection in a dynamic biopharmaceutical environment...
Reposted 5 days ago
Field Consultant, CLESS (Construction Defect)
$108K - $200K *
Champion the resolution of complex commercial casualty claims by delivering exceptional customer service, conducting thorough investigations, and collaborating with defense counsel to ensure fair outc...
6 days ago
$175K - $190K *
Shape the future of search by designing intuitive, engaging experiences that enhance user interactions and drive revenue. Collaborate with cross-functional teams to create a seamless journey for neigh...
1 week ago
AEC Healthcare Project Manager
$110K - $130K *
Shape the future of healthcare by leading complex architectural and facility projects, ensuring optimal client service and regulatory compliance throughout all project phases while guiding multidiscip...
Reposted 1 week ago
Managing Consultant - Clinical Documentation Integrity (CDI) - Healthcare
$120K - $165K *
Drive the successful transfer of CDI best practices by mentoring client teams, conducting record reviews, and delivering education. Collaborate with healthcare professionals to enhance documentation a...
4 weeks ago
Medical Director, Medical Affairs
$174K - $374K *
Lead the charge in clinical oversight and mentorship, driving innovative medical solutions across diverse programs. Collaborate with cross-functional teams to ensure evidence-based decision-making and...
2 weeks ago
Director, Business Development
$120K - $150K *
Drive full-cycle sales for global clinical operations, fostering client relationships and developing strategic plans for service growth in alignment with company objectives...
Reposted 2 weeks ago
Medical Director, Utilization Management
$180K - $220K *
Lead the evaluation of outpatient referrals and inpatient admissions for medical necessity, utilizing guidelines and criteria to ensure quality care. Collaborate with providers and mentor UM nurses to...
Today
Clinical Consultant (Vue PACS)
$90K - $143K *
Unlock potential by serving as a clinical consultative partner, guiding healthcare customers through PACS solutions, ensuring successful implementation, and fostering strong relationships to drive cus...
Reposted today
$94K - $130K *
Elevate product outcomes by collaborating with teams to prioritize and define user stories, ensuring alignment with business needs while maximizing value delivery and maintaining product quality throu...
Yesterday
$95K - $206K *
Join a dynamic team as a Clinician Player Coach, mentoring peers while delivering high-quality in-home evaluations. Balance clinical duties with mentorship, ensuring exceptional care and support for n...
4 weeks ago
Data Mining Specialist (Payment Integrity)
$93K - $134K *
Drive impactful data mining initiatives by analyzing complex claims across Medicare, Medicaid, and Commercial sectors. Leverage your expertise to identify anomalies and enhance recovery opportunities...
Today
Senior Director, Counsel, Diagnostics & Medical Devices
$199K - $321K *
Join a dynamic team to provide strategic legal counsel on diagnostics and medical devices, ensuring compliance with FDA regulations and commercial strategies while collaborating across business units...
1 week ago
Account Specialist (Norfolk, VA)
$160K - $192K *
Grow your career by engaging healthcare providers and driving commercial success. Collaborate with cross-functional teams to support product launches and enhance patient access to innovative therapies...
1 week ago
Account Specialist (Mayfield Heights, OH)
$160K - $192K *
Discover a pivotal role in driving commercial performance and patient access. Engage healthcare providers, build relationships, and support product launches while collaborating with cross-functional t...
1 week ago
$72K - $192K *
Join a team that's dedicated to enhancing client relationships in healthcare. As a trusted advisor, you'll guide clients through workflows, drive feature adoption, and develop strategic plans to maxim...
Yesterday
Physician | Neurosurgery Inpatient Only
$280K - $350K *
Lead the charge in providing exceptional medical care and patient education. Collaborate with a dedicated team to assess, diagnose, and treat patients, ensuring adherence to safety standards and quali...
1 week ago
$100K - $122K *
Unlock potential by leading a dynamic accounting team, managing full-cycle accounting processes, ensuring compliance, and driving process improvements in a fast-paced environment. Collaborate with fin...
3 weeks ago
Regional Sales Director - Charlotte
$180K - $215K *
Lead regional sales initiatives, driving product launch success and team performance. Collaborate cross-functionally to execute strategies, foster customer relationships, and ensure compliance while b...
1 week ago
Senior Manager, Growth Marketing
$110K - $130K *
Accelerate progress at an innovative healthcare firm by leading account-based marketing initiatives. Collaborate closely with Sales to create impactful marketing plays that engage targeted health syst...
1 month ago
$120K - $145K *
Join a dynamic finance team as you oversee financial reporting, manage reconciliations, and enhance accounting processes. Your expertise will ensure compliance with GAAP while supporting audits and op...
Reposted 4 days ago
$160K - $170K *
Join a team that's redefining production excellence by leading end-to-end photo and video shoots. You'll manage budgets, build partnerships, and create efficient workflows while ensuring brand integri...
2 weeks ago
Senior Consultant - Strategic Sourcing & Procurement Transformation
$110K - $130K *
Join a team that's transforming procurement operations through innovative strategies and data-driven solutions. Leverage your consulting expertise to enhance client outcomes and drive impactful change...
1 week ago
$95K - $110K *
Take ownership of nursing excellence by leading a dedicated team to deliver high-quality care in a supportive environment. Foster relationships and drive clinical practices while ensuring compliance w...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.