Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Sr Epic Bridges Integration Engineer
$110K - $130K *
Champion seamless data integration across IT systems by leading complex projects, troubleshooting issues, and optimizing performance. Leverage your expertise in integration technologies to ensure data...
3 weeks ago
$80K - $95K *
Join a dynamic team to design and develop innovative software applications, enhancing internal processes and client interactions. Leverage your technical expertise in Salesforce, SQL, and Agile method...
Yesterday
Director Continuous Improvement
$120K - $150K *
Champion continuous improvement initiatives by optimizing processes and products across the organization. Lead cross-functional teams to enhance operational efficiency, quality, and customer experienc...
2 weeks ago
$110K - $130K *
Join a team that's leading Medicaid programs and initiatives, driving operational excellence and policy implementation while managing multidisciplinary teams and enhancing organizational performance a...
2 weeks ago
Principal Technical Strategist - NextGen (Remote)
$180K - $275K *
Unlock potential by defining and driving the technical vision and product strategy for Next-Gen SIEM and Log Management products, ensuring alignment with market needs and customer motivations while fo...
1 week ago
Process & Technology Specialist
$66K - $128K *
Transform sales operations by owning CRM administration, building dashboards, and automating processes. Collaborate with teams to enhance technology adoption and streamline workflows, ensuring effecti...
Today
Corporate Counsel, Global Supply Chain
$134K - $231K *
Shape the future of global supply chain operations by providing strategic legal support, drafting contracts, and ensuring compliance with environmental and safety regulations. Collaborate across funct...
Reposted 4 days ago
Clinical Expert Advisor - Remote, US
$162K - $224K *
Transform healthcare operations by leveraging your expertise to drive efficiency and improve outcomes. Engage with clients to analyze needs, manage projects, and lead teams in delivering sustainable p...
Yesterday
$80K - $95K *
Champion exceptional research outcomes by guiding clients through complex projects. Leverage your expertise in methodology and analysis to deliver actionable insights, while collaborating with cross-f...
1 week ago
Senior Analytics Solutions Engineer
$80K - $110K *
Design and develop advanced analytics solutions, transforming complex healthcare data into actionable insights using Azure Databricks and Power BI. Collaborate with cross-functional teams to enhance r...
3 days ago
Regional Sales Director - St. Louis
$180K - $215K *
Tackle the challenge of launching a groundbreaking product by leading a high-performing sales team, driving regional execution, and fostering key customer relationships in a dynamic, fast-paced enviro...
1 week ago
Senior Account Strategist (Remote)
$88K - $105K *
Shape the strategic direction of client marketing programs by developing and executing integrated strategies, leading client conversations, and translating data into actionable insights that drive mea...
Reposted 2 weeks ago
$370K - $490K *
Join a dynamic team to lead enterprise retail sales, driving strategic growth across diverse categories. Coach senior Account Executives, manage complex deals, and build relationships with top merchan...
1 week ago
Associate Vice President - Strategic Accounts & Client Success - Remote
$144K - $240K *
Transform healthcare delivery by leading strategic initiatives and optimizing infusion services. Drive client success through expert guidance, operational excellence, and innovative solutions, ensurin...
Reposted today
Account Specialist (Norwich, CT)
$160K - $192K *
Drive commercial success by engaging healthcare providers and executing territory plans. Collaborate with cross-functional teams to support product launches and enhance patient access to innovative th...
1 week ago
Senior Analyst, Technical Implementation
$89K - $133K *
Empower success by leading healthcare technology implementations, optimizing workflows, and ensuring compliance. Collaborate across teams to guarantee smooth integrations and enhance system functional...
Reposted 1 week ago
Software Engineer - Full Stack
$110K - $130K *
Contribute to innovative digital platforms by developing scalable, secure, and high-performing applications. Drive efficiency and enhance customer outcomes through full-stack development, cloud archit...
3 weeks ago
Software Engineer - Full Stack
$110K - $130K *
Engineer scalable, secure digital platforms that enhance product delivery and operational efficiency. Drive end-to-end development across web frontends, APIs, and microservices while ensuring complian...
3 weeks ago
Manager, Product Management, Member Interaction & Engagement Data
$108K - $180K *
Shape the future of product development, leading cross-functional teams to execute strategic initiatives and optimize customer engagement through innovative data solutions and market insights. Drive i...
Reposted 1 month ago
Quality Compliance & AI Operations Analyst
$80K - $90K *
Advance quality assurance initiatives and optimize workflows in a remote healthcare contact center. Collaborate cross-functionally to enhance compliance, improve patient outcomes, and drive continuous...
6 days ago
Hemostasis Sales Specialist - Northern California Region
$99K - $136K *
Elevate your career by driving strategic growth in Hemostasis solutions. As a key player, you'll lead complex sales cycles, cultivate executive relationships, and deliver measurable value across healt...
2 weeks ago
$125K - $157K *
Transform training programs by designing and implementing comprehensive sales and clinical training for orthopedic robotics, ensuring teams are equipped to excel in promoting robotic-assisted procedur...
2 weeks ago
$110K - $125K *
Join a team that's driving innovation in billing and data platforms. As a Senior Product Owner, you'll lead agile delivery, manage complex features, and ensure high-quality releases while collaboratin...
4 weeks ago
Physician Assistant or Nurse Practition | Family Medicine
$85K - $100K *
Join a team that's dedicated to providing comprehensive medical care by assessing, diagnosing, and treating patients while promoting health education and collaboration with physicians to enhance patie...
1 week ago
$80K - $95K *
Transform lender relationships by managing program performance, onboarding, and communication. Collaborate with leadership to identify trends and opportunities, ensuring clarity and efficiency in fina...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.