Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$75K - $90K *
Drive innovative advertising strategies by transforming customer insights and performance data into compelling creative content. Collaborate with cross-functional teams to enhance product visibility a...
1 week ago
$210K - $250K *
Transform patient care by providing comprehensive medical evaluations, diagnoses, and treatments. Collaborate with healthcare teams to enhance health education and ensure quality care while adhering t...
6 days ago
Genesys Cloud Access Management
$89K - $121K *
Shape the future of customer engagement by optimizing Genesys Cloud access management. Collaborate with cross-functional teams to enhance security, streamline user provisioning, and ensure compliance...
1 week ago
Regional Sales Director - Washington D.C.
$180K - $215K *
Shape the future of healthcare by leading regional sales efforts, driving product launch success, and building high-performing teams. Collaborate cross-functionally to achieve sales goals and foster s...
1 week ago
Account Director, Promotional Medical Education
$100K - $120K *
Partner with us to drive strategic healthcare marketing initiatives. Lead client relationships, oversee peer-to-peer programs, and mentor team members to ensure compliance and achieve results while fo...
Reposted 1 week ago
$96K - $144K *
Take ownership of contract management by drafting, negotiating, and administering agreements with key customers. Collaborate with cross-functional teams to ensure compliance and operational efficiency...
Yesterday
Analyst/Senior Analyst, Business Operations & Strategy
$95K - $130K *
Tackle strategic business challenges by leveraging data insights to drive growth. Collaborate cross-functionally to enhance operational efficiency, support marketing initiatives, and influence product...
Yesterday
Advanced Practice Provider - Pain Management
$90K - $110K *
Elevate patient care by managing complex cases in collaboration with healthcare teams. Utilize your expertise to assess, diagnose, and implement treatment plans, ensuring optimal outcomes in an outpat...
3 weeks ago
$80K - $95K *
Join a team that's dedicated to enhancing patient safety through data analysis, audits, and collaboration across departments. Drive improvements in EHR software and support quality initiatives to ensu...
1 week ago
$100K - $120K *
Elevate patient care by providing expert pharmacy consulting and clinical services. Collaborate with a dedicated team to ensure medication safety and mentor future pharmacists while enjoying growth op...
1 week ago
$100K - $120K *
Join a dynamic team to provide expert pharmacy consulting, educate patients on medications, and deliver clinical healthcare services while ensuring safety and compliance. Mentor colleagues and enhance...
1 week ago
Product Manager - Find & Schedule Care
$86K - $138K *
Champion the seamless member experience in healthcare access by defining product strategy and overseeing execution. Drive innovation in finding and scheduling care, ensuring accuracy and satisfaction...
Reposted 5 days ago
$210K - $260K *
Transform the workplace culture and integration of two organizations, ensuring support for clinicians and staff while enhancing benefits, compensation, and recruitment strategies to foster a unified m...
3 days ago
$200K - $232K *
Unlock potential by leading legal reviews for promotional and medical materials. Collaborate across teams to ensure compliance and provide practical guidance in a fast-paced environment, supporting pr...
2 weeks ago
$100K - $120K *
Join a dynamic team to enhance website performance and user experience through innovative SEO strategies, technical audits, and content optimization, driving organic visibility and business results on...
3 weeks ago
Clinical Informatics Specialist
$102K - $133K *
Unlock potential by optimizing clinical systems and driving informatics initiatives. This role combines strategy with hands-on support across EHR applications, fostering collaboration to enhance workf...
Reposted 3 weeks ago
$90K - $110K *
Transform healthcare delivery by leading clinical operations, ensuring high-quality patient care, and fostering collaboration across departments. Drive strategic initiatives while managing resources a...
3 weeks ago
Senior Product Manager - Remote US
$130K - $140K *
Innovate within the healthcare sector by identifying market gaps and designing impactful products. Collaborate across teams to drive product strategy, ensuring solutions meet industry needs while enha...
3 weeks ago
$302K - $483K *
Transform the future of secure platforms by leading engineering strategy and execution. Drive innovation, operational excellence, and team performance to empower autonomy and accountability across the...
Today
Case Manager - Healthcare Appeals & Patient Access Advocate
$83K - $112K *
Partner with us to navigate complex patient cases and ensure seamless access to care. Utilize critical thinking and communication skills to manage authorizations and appeals, collaborating with divers...
Reposted 5 days ago
$90K - $110K *
Lead the charge in managing contracts for utility-scale solar and infrastructure projects. Collaborate with cross-functional teams to ensure compliance, streamline documentation, and support project c...
2 weeks ago
Senior Vice President, Delivery - Denials Resolution and Payment Compliance
$210K - $250K *
Shape the future of healthcare delivery by leading operations in denials resolution and payment compliance. Drive performance, quality, and financial outcomes while building a high-performing team and...
6 days ago
$80K *
Empower clients by managing complex care needs through remote case management, ensuring access to high-quality treatment and support. Collaborate with multidisciplinary teams to enhance client engagem...
2 weeks ago
$110K - $160K *
Join a dynamic team of engineers to develop innovative software solutions, enhance user experiences, and drive impactful projects. Collaborate across functions while embracing modern technologies and...
3 weeks ago
Global Scientific Evidence Manager, Restorative Procedures
$143K - $196K *
Lead global evidence strategy and drive scientific engagement while collaborating cross-functionally to identify evidence gaps and shape priorities in clinical, R&D, and marketing teams. Make a signif...
6 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.