Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior IT Engineer, Identity and Access Management
$117K - $164K *
Transform your career by leading Identity and Access Management initiatives, enhancing security protocols, and driving automation in a dynamic IT environment. Collaborate with cross-functional teams t...
Yesterday
$120K - $165K *
Elevate your career as a Scientific Product Owner, driving innovation in clinical genomics software. Collaborate with cross-functional teams to translate scientific needs into actionable requirements...
1 week ago
Senior Datadog Security & Observability Engineer
$125K - $150K *
Elevate security observability by enhancing Datadog's capabilities across cloud and corporate environments, ensuring actionable detection aligned with real-world threats while collaborating with cross...
Reposted 4 weeks ago
$103K - $123K *
Drive growth by managing a sales territory, building relationships, and generating premium. Leverage existing partnerships while prospecting new agencies to achieve targets and expand market presence...
1 week ago
Manager, Client Delivery Experience (CDE PMO) - Remote
$105K - $163K *
Champion client success by leading project teams to deliver high-quality card processing solutions. Drive enhancements, manage complex implementations, and ensure client satisfaction through effective...
4 weeks ago
$140K - $160K *
Accelerate progress at a dynamic tech firm by owning the full sales cycle for mid-market practices. Collaborate with leadership to shape strategy and drive impactful relationships, ensuring success in...
1 week ago
Director of Services - US West
$150K - $200K *
Engage in leading a dynamic team dedicated to delivering top-notch offensive security engagements, ensuring delivery quality and client satisfaction, while collaborating with sales to expand accounts...
Reposted 3 weeks ago
Enterprise Architect - Oracle CX, ERP, HCM & SCM
$135K - $160K *
Lead enterprise architecture strategy across Oracle CX, ERP, HCM, and SCM Cloud. Collaborate with stakeholders to develop scalable solutions, ensuring alignment with business capabilities and technolo...
1 week ago
$130K - $150K *
Champion strategic direction and team excellence in social media buying. Drive business growth, oversee media execution, and mentor high-performing teams while maintaining deep industry expertise and...
1 month ago
$75K - $95K *
Empower customer success through strategic account management and relationship building. Collaborate closely with clients to ensure satisfaction and retention, while driving revenue and addressing uni...
Reposted 3 weeks ago
Director, BioPharma Business Development
$150K - $180K *
Unlock potential by driving BioPharma partnership success through innovative liquid biopsy solutions, enhancing clinical trial designs, and fostering key relationships in oncology precision medicine...
Reposted 1 week ago
$130K - $150K *
Lead the charge in integrating complex hospital data systems into Astra OS. Own end-to-end data pipelines, collaborate with customers, and design scalable solutions that enhance healthcare operations...
4 weeks ago
$140K - $190K *
Join a team that's transforming clinical trials through advanced data science. Drive the development of predictive models and machine learning algorithms to enhance patient enrollment and trial manage...
2 weeks ago
$147K - $192K *
Tackle new opportunities in the healthcare sector by driving sales and strategy. Engage with C-suite executives, implement effective sales policies, and analyze market trends to maximize revenue growt...
Reposted 1 week ago
$185K - $327K *
Unlock potential by leading security strategy and architecture, partnering with the CISO to enhance technical oversight and incident response. Drive secure practices across teams while mentoring engin...
4 weeks ago
Senior Decision Support Analyst
$71K - $112K *
Drive impactful financial and operational analysis to enhance performance. Collaborate with stakeholders, mentor junior analysts, and present insights that inform strategic decisions across the organi...
1 week ago
Head of Customer Success, Payer & Employer
$137K - $205K *
Transform customer relationships by leading a team to enhance account management, drive product adoption, and ensure client success in the healthcare sector, fostering growth and retention across dive...
3 weeks ago
21GRAMS- Associate Creative Director, Art
$160K - $180K *
Elevate healthcare creativity by leading innovative campaigns that transform client brands. Collaborate with teams to deliver impactful experiences across digital channels, leveraging insights and eme...
3 days ago
$120K - $250K *
Transform clinical trials by ensuring patient safety and scientific integrity. Collaborate with stakeholders to uphold regulatory standards and optimize study protocols, while providing expert medical...
2 weeks ago
Sr. Medical Director, Rheumatology - US Remote
$173K - $320K *
Shape the future of rheumatology by providing strategic medical oversight across clinical trials. Lead the innovation and development of groundbreaking therapies while collaborating with multidiscipli...
Reposted 2 weeks ago
Contractor - Trauma Program - Emergency Services
$80K - $95K *
Elevate your career by leading trauma program initiatives in emergency services. Collaborate with multidisciplinary teams to enhance patient care and optimize operational efficiency in a fast-paced en...
1 week ago
$120K - $145K *
Unlock potential by designing and optimizing cloud-based data platforms, ensuring scalability and performance across relational, NoSQL, and vector databases while collaborating with AI and engineering...
3 weeks ago
Principal Product Manager, Member Experience
$200K - $230K *
Champion a transformative member software experience, guiding strategy and design across the care journey. Leverage data and user insights to drive impactful solutions in a complex healthcare landscap...
2 weeks ago
Senior Quality Assurance Engineer
$95K - $130K *
Empower your career by leading quality assurance efforts for critical healthcare systems. Collaborate with teams to enhance user experiences for Veterans, ensuring high-quality service delivery throug...
2 days ago
Senior Project Manager - Construction Administration
$126K - $162K *
Join a dynamic team to lead construction administration projects, ensuring seamless execution from design to closeout. Collaborate with stakeholders, manage client relations, and drive project success...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.