Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Manager, Product Management - Provider Contracting, Credentialing & Network
$108K - $180K *
Join us in leading product strategy and execution for a diverse portfolio, enhancing Provider Contracting and Credentialing. Collaborate with cross-functional teams to drive innovation, improve custom...
3 days ago
21GRAMS- Associate Medical Strategy Director
$120K - $135K *
Join a team that shapes innovative medical strategies, driving excellence in healthcare content. Collaborate with experts, cultivate client relationships, and inspire teams to elevate project outcomes...
Reposted 1 week ago
$260K - $270K *
Unlock your potential as a Psychiatrist, providing advanced outpatient care via virtual platforms. Collaborate with multidisciplinary teams to deliver comprehensive treatment for diverse psychiatric c...
6 days ago
$80K - $110K *
Discover your potential by supporting data-driven decision-making as you develop and implement advanced statistical and machine learning models. Collaborate with stakeholders and enhance your skills i...
Reposted 3 weeks ago
In-Home Traveler Physician Full Time - Delaware
$174K - $374K *
Inspire health and wellness by conducting in-home evaluations, building relationships, and bridging care gaps. Travel extensively to provide personalized health assessments, ensuring comprehensive sup...
3 weeks ago
Physician, OB/GYN - Telemedicine Opportunity - DrHouse
$210K *
Unlock potential by delivering high-quality virtual care as a board-certified OB/GYN. Manage diverse clinical cases through telehealth, ensuring patient-centered treatment while enjoying a flexible sc...
2 days ago
Physician, OB/GYN - Telemedicine Opportunity - DrHouse
$210K *
Shape the future of telehealth by delivering compassionate, patient-centered care. Join a dynamic team of board-certified OB/GYN physicians providing virtual consultations across South Dakota, balanci...
2 days ago
21GRAMS- VP, Medical Strategy Director
$180K - $195K *
Elevate healthcare marketing by transforming complex science into impactful strategies. Lead multidisciplinary teams to inspire creativity, drive behavior change, and build trusted client relationship...
Reposted 1 week ago
Enterprise Account Director - US Large Law Firms
$240K - $300K *
Drive revenue growth by engaging top-tier law firms, cultivating relationships, and executing strategic sales initiatives. Collaborate with leadership to exceed sales targets and enhance market presen...
3 days ago
$100K - $120K *
Join a team that's driving innovative marketing strategies to enhance brand growth and engagement. You'll lead a small team, manage multi-channel campaigns, and collaborate with operations to elevate...
2 weeks ago
Certified Physician Assistant/ Certified Nurse Practitioner
$85K - $100K *
Inspire your career with a role supporting physicians and enhancing patient recovery through hands-on medical care, assessments, and collaboration in a dynamic healthcare environment...
Reposted 2 weeks ago
$108K - $180K *
Transform pharmacy services by driving strategic initiatives and cross-functional projects. Collaborate with stakeholders, analyze outcomes, and mentor team members while shaping the future of pharmac...
4 weeks ago
$210K - $250K *
Join a dedicated team providing comprehensive medical care and education to patients. Assess, diagnose, and treat with a focus on quality and safety, while collaborating with healthcare professionals...
6 days ago
$45K - $250K *
Transform your career by connecting healthcare professionals with meaningful roles. Join a supportive team focused on building relationships and driving results while enjoying unlimited earning potent...
1 week ago
$150K - $180K *
Join a dynamic team to lead and scale clinical operations, overseeing performance and process optimization. Build accountable teams, manage metrics, and partner with stakeholders to enhance operationa...
Reposted 4 weeks ago
Associate Director, Compliance
$110K - $130K *
Drive the enhancement of Compliance Monitoring and Testing programs, ensuring regulatory alignment and effective risk management. Collaborate with stakeholders to improve operational efficiency and su...
1 week ago
$90K - $110K *
Elevate your career by managing accounting activities, ensuring compliance, and collaborating across teams to enhance financial accuracy and internal controls in a dynamic environment...
2 days ago
Epic Systems Analyst - Ambulatory
$68K - $105K *
Transform your career by configuring and supporting Epic applications. Engage in systems analysis, design, and problem resolution while collaborating with end-users to enhance their experience and str...
2 days ago
$144K - $160K *
Champion operational excellence by leading teams to enhance efficiency and care delivery. Drive AI integration, manage P&L, and collaborate cross-functionally to support growth and sustainability in h...
1 week ago
Customer Development Specialist - Chesapeake
$68K - $93K *
Unlock potential by driving sales through strategic customer engagement and relationship management. Utilize digital tools and territory management to enhance customer experiences and achieve sales ta...
1 week ago
Senior Safety Physician - CNS (remote)
$222K - $356K *
Unlock your potential as a Senior Safety Physician, leading safety oversight for late-stage CNS clinical development. Collaborate with cross-functional teams to drive risk management and regulatory su...
Reposted 2 weeks ago
$80K - $95K *
Drive revenue cycle optimization by enhancing Epic Professional Billing workflows, collaborating with stakeholders, and resolving claims challenges to improve overall operational efficiency and ensure...
4 weeks ago
$110K - $130K *
Join a team that's dedicated to creating impactful medical education content for healthcare providers and patients. Collaborate closely with scientific and account teams to deliver high-quality materi...
Reposted yesterday
Certified Registered Nurse Anesthetist | Rapid City Hospital
$160K - $190K *
Shape the future of anesthetic care by collaborating with a dedicated team to provide safe, patient-focused services. Your expertise will drive quality outcomes in a supportive environment that champi...
Reposted today
$100K - $120K *
Elevate your career by designing and optimizing EpicCare Ambulatory workflows. Collaborate with clinicians to enhance EHR functionality, troubleshoot issues, and ensure seamless operations across heal...
Today
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.