Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
QA Analyst, Keeper App (Backend & Platform)
$90K - $110K *
Advance quality assurance efforts by designing and executing tests for backend systems and APIs, ensuring data integrity and performance across cloud environments. Collaborate with engineers to enhanc...
3 weeks ago
Operations Director, Biomarker Programs
$175K - $200K *
Lead the charge in optimizing biomarker program operations, ensuring seamless sample processing from collection to storage. Collaborate across teams to uphold quality and compliance while driving grow...
2 weeks ago
$105K - $115K *
Optimize medical device utilization in health systems by leveraging expertise in cardiovascular, interventional radiology, and general surgery. Collaborate with stakeholders to drive cost reduction an...
2 weeks ago
$80K - $110K *
Drive client growth by enhancing software adoption and satisfaction. Collaborate with sales and success teams to implement strategies, facilitate demos, and manage client relationships, ensuring long...
1 week ago
$100K - $120K *
Join us to empower community coalitions in preventing youth substance use. As a Project Officer, you'll manage grants, provide technical assistance, and enhance local capacities, all while collaborati...
Yesterday
Advanced Practice Provider - Clinical Research Oncology
$85K - $100K *
Join a dynamic healthcare team as you manage complex patient populations, collaborating with physicians and nurses to deliver high-quality care. Utilize your expertise in a predominantly outpatient se...
2 weeks ago
Principle Div Consultant- Medicare Provider Network Strategy - Remote
$92K - $167K *
Drive strategic initiatives in Medicare Advantage provider networks, analyzing data and collaborating with leadership to enhance performance and achieve goals. Lead complex projects from inception to...
3 weeks ago
Vice President, Finance & Operations (Remote)
$160K - $200K *
Lead the charge in financial strategy and operational excellence, driving growth and sustainability for a mission-driven organization. Collaborate with leadership to implement innovative solutions and...
3 weeks ago
$110K - $130K *
Join a team that's dedicated to transforming healthcare data solutions. As a Senior Data Engineer, you'll enhance complex systems, collaborate across departments, and drive analytics to optimize finan...
Reposted 2 weeks ago
$110K - $130K *
Accelerate your career by driving revenue growth with enterprise clients. Leverage your sales expertise in the fashion industry to build relationships, identify needs, and deliver tailored solutions t...
Yesterday
$70K - $95K *
Drive quality assurance initiatives by leading investigations, maintaining documentation, and partnering with cross-functional teams to enhance product quality and operational efficiency while ensurin...
Reposted 3 weeks ago
Director, Compliance Assurance
$125K - $150K *
Join a team that's dedicated to enhancing compliance excellence through strategic oversight of operations, risk management, and audit processes. Collaborate with leadership to drive regulatory complia...
Reposted 2 weeks ago
$125K - $150K *
Shape compliance excellence by overseeing post-closing functions, managing risks, and driving continuous improvement. Collaborate with stakeholders to ensure adherence to regulations and enhance the C...
3 weeks ago
Specialist, Workers' Compensation
$100K - $130K *
Join a team that's redefining Workers' Compensation filings. Leverage your expertise to manage complex engagements, navigate state regulations, and serve as a trusted advisor, ensuring compliance and...
6 days ago
Specialty Development Executive - Northeast Territory
$130K - $140K *
Accelerate the growth of colorectal cancer screening solutions by engaging healthcare providers and driving product adoption. Collaborate with partners while strategically planning to maximize market...
Reposted 2 weeks ago
Vice President, Business Intelligence Engineer
$150K - $180K *
Innovate data-driven strategies to enhance business decision-making and optimize reporting processes. Leverage expertise in BI, CRM Analytics, and Salesforce to deliver actionable insights and support...
Reposted yesterday
$150K - $180K *
Join a team that's redefining scientific data management in drug discovery. Lead the scientific data team, bridging scientists and engineers to ensure data integrity, quality, and innovative solutions...
3 weeks ago
Account Specialist (Palo Alto / San Francisco, CA)
$160K - $192K *
Lead the charge in driving commercial performance by engaging healthcare providers, building relationships, and executing territory business plans to ensure patient access to innovative therapies and...
1 week ago
$160K - $200K *
Drive the M&A strategy by leading the full transaction lifecycle, from sourcing to integration. Collaborate with executive leadership to identify growth opportunities that enhance enterprise value and...
2 weeks ago
Director, Global Field Sales Operations
$187K - $257K *
Elevate global sales operations by leading forecasting, pipeline management, and productivity initiatives. Collaborate with sales leaders to enhance clarity and consistency, driving growth through inn...
1 week ago
Director, Value Consulting & Digital Transformation
$113K - $160K *
Champion the quantification of business impact from technology and transformation investments. Lead financial modeling and value realization efforts, translating insights into actionable recommendatio...
3 days ago
Senior Director, Analytical Sciences
$215K - $240K *
Shape the future of drug development by leading analytical strategies, ensuring compliance and optimization of processes across lifecycle stages, and collaborating with cross-functional teams and exte...
4 weeks ago
$150K - $180K *
Champion a transformative product vision, leading cross-functional teams to drive strategic outcomes in a dynamic digital health environment. Shape the future of patient care and client experience whi...
1 week ago
$80K - $95K *
Deliver comprehensive psychological assessments and evidence-based interventions, guiding treatment plans for complex cases. Collaborate with interdisciplinary teams and supervise trainees while enhan...
Today
Sr. Talent Acquisition Partner
$100K - $120K *
Shape the future of executive recruitment by leading strategic sourcing, engaging high-level candidates, and collaborating with a dedicated team to uncover top talent. This role offers growth opportun...
Reposted 2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.