Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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Dentist Jobs in South Dakota

Sort By: Relevance

$89K - $105K *

Deliver compelling marketing and policy content that enhances brand voice and reputation. Collaborate with teams to translate complex topics into clear narratives, ensuring high-quality, timely materi...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Empower a dynamic sales team as a player-coach, driving growth in the dental market. Lead, coach, and sell while fostering accountability and performance improvement to achieve team goals and enhance...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$55K - $109K *

Engage in leading the dental Provider Relations team, enhancing provider relationships and operational effectiveness. Drive network management activities to ensure member access to care and improve pr...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$210K - $250K *

Lead the charge in providing remote clinical oversight for Dermatology PAs, ensuring high-quality patient care and compliance with regulations. Collaborate with a dedicated team to foster clinical exc...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$130K - $190K *

Empower veterinary professionals by delivering expert dermatology advice and support, enhancing case management, and fostering strong relationships. Join a dynamic team committed to advancing veterina...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Empower patient health by using your clinical expertise to oversee medication management and collaborate with healthcare professionals, ensuring optimal therapeutic outcomes across care settings for d...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Join a team that's dedicated to enhancing client relationships and driving success. Oversee client performance, mentor staff, and ensure compliance while collaborating with various departments to deli...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Champion client success by overseeing relationships, ensuring operational excellence, and mentoring teams to exceed expectations. Utilize analytics to drive performance and resolve issues, fostering c...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $150K *

Shape Overjet's innovative content strategy, crafting compelling materials that drive engagement and conversions for diverse dental audiences. Collaborate across teams, leveraging data and creative to...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $100K *

Elevate your career with a dynamic veterinary team, providing exceptional care in a state-of-the-art facility. Join us to make a difference in animal health while enjoying a supportive environment and...

6 days ago

  •   Less than 5 years exp.  •   Technical Services

$80K - $95K *

Empower healthcare technology by enhancing clinical systems and integrations. Collaborate with IT and business stakeholders to optimize workflows, manage projects, and ensure system performance across...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$79K - $127K *

Innovate with us to enhance data protection strategies, ensuring robust security and compliance across diverse platforms. Collaborate on complex projects, troubleshoot incidents, and drive improvement...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $140K *

Transform global client relationships by driving revenue growth and strategic account management. Collaborate with C-suite executives to connect workplace culture and employee experience to measurable...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Finance & Insurance

$80K - $95K *

Empower clinical excellence by delivering expert technical support for neurovascular products. Collaborate with healthcare professionals to enhance patient care, drive product adoption, and ensure suc...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$150K *

Drive new business growth by owning the full sales cycle in SMB and Mid-Market segments. Build relationships, strategize territory plans, and deliver compelling proposals to meet client needs while ex...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $160K *

Lead the charge in transforming claims management by leveraging your expertise to drive data-informed decisions, enhance processes, and foster collaboration across teams, ensuring exceptional service...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$155K - $217K *

Join a dynamic team to negotiate and close high-profile commercial agreements, supporting various business units while driving growth in a leading SaaS company. Collaborate closely with sales and prod...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$153K - $210K *

Transform your career by partnering with teams to drive strategic growth through legal expertise in healthcare contracts, negotiations, and compliance. Collaborate with leadership to optimize performa...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Take ownership of financial and operational analysis for strategic initiatives, delivering critical insights and reporting to support executive decision-making while driving accuracy and efficiency in...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Join a pioneering team to build an AI-enabled care delivery platform, bridging clinical expertise and engineering to create safe, effective patient care solutions. Drive innovation from concept to pro...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in expanding into new healthcare verticals by developing and executing go-to-market strategies, managing partnerships, and driving campaign performance. Collaborate with cross-function...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$240K - $300K *

Transform patient care by providing comprehensive medical evaluations, diagnoses, and treatments. Collaborate with healthcare teams to enhance health education and ensure quality care while adhering t...

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$270K - $280K *

Join a team that's driving clinical excellence by overseeing trial execution, managing timelines, budgets, and CROs. Collaborate with stakeholders to ensure compliance and quality while mentoring team...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$174K - $374K *

Engage with patients in their homes to conduct health evaluations, build relationships, and bridge care gaps. This role demands extensive travel and flexibility to provide personalized care and diagno...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Join a team that's dedicated to providing exceptional anesthetic care in a Level II Trauma Center. Engage in diverse procedures and enjoy a supportive work environment with opportunities for professio...

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.