Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Principal Product Builder, Data
$205K - $256K *
Transform your career by leading Apollo's data strategy, ensuring the highest quality B2B data for GTM success. Drive product vision, collaborate cross-functionally, and enhance customer experiences t...
1 week ago
$80K - $95K *
Drive customer satisfaction and growth by nurturing relationships, identifying upsell opportunities, and collaborating on account strategies. Leverage industry insights to maximize account potential a...
4 weeks ago
Solutions Architect, Digital Platforms
$188K - $282K *
Drive the architecture for customer data integration across digital platforms, ensuring secure ingestion and transformation. Collaborate with cross-functional teams to create scalable solutions that e...
Yesterday
$135K - $196K *
Unlock potential by shaping the demo experience through innovative tooling and infrastructure. Collaborate across teams to enhance product communication and drive secure access solutions, all while le...
Yesterday
$200K - $300K *
Drive product strategy and lifecycle management, ensuring alignment with market needs and business growth. Lead cross-functional teams to develop, launch, and support innovative medical devices while...
Reposted 2 days ago
Clinical Informatics & Ontology Lead
$120K - $145K *
Lead the design and governance of clinical ontologies and terminology services, ensuring data quality and alignment with product needs. Collaborate cross-functionally to enhance data normalization and...
Yesterday
Director, Consumer Acquisition
$229K - $267K *
Optimize consumer acquisition strategies to drive growth and innovation across multiple channels. Lead a high-performing team, manage budgets, and define future goals while ensuring effective executio...
3 weeks ago
$110K - $130K *
Engage in the design and management of enterprise endpoint technologies, ensuring security and efficiency across over 1,000 devices. Collaborate with cross-functional teams to enhance endpoint perform...
3 weeks ago
Manager, Clinical Data Acquisition
$73K - $130K *
Drive the acquisition and usability of clinical data to enhance healthcare outcomes. Collaborate with diverse teams to analyze data gaps, implement integrations, and optimize processes, ensuring timel...
3 weeks ago
Account Specialist (Athens, GA)
$160K - $192K *
Drive commercial success by engaging healthcare providers and executing territory plans. Collaborate with cross-functional teams to support product launches and enhance patient access to innovative th...
5 days ago
$80K - $90K *
Lead the visual narrative of client brands by delivering exceptional design solutions across multiple channels. Collaborate with diverse teams to uphold high standards and participate in innovative pr...
Reposted 2 weeks ago
Analyst - Information Technology
$66K - $113K *
Champion enterprise portfolio reporting and analytics, developing insights to drive strategic decision-making and enhance project visibility. Collaborate across teams to create actionable dashboards a...
4 weeks ago
$148K - $185K *
Join us to create user-centered designs that enhance account opening experiences for banks and credit unions, collaborating closely across teams to innovate and uphold a high standard of quality and c...
Reposted 1 week ago
$160K - $200K *
Join a team that's redefining forensics and collections globally. Lead a skilled team, enhance operational efficiency, and drive client engagement while ensuring compliance and defensibility across re...
1 week ago
$110K - $160K *
Lead the charge in driving growth and strategy for our largest pro partners by leveraging data insights. Manage cross-functional projects to shape impactful initiatives, build frameworks, and measure...
Reposted 4 weeks ago
$100K - $120K *
Join us to oversee pharmacy services, ensuring quality care through effective planning, execution, and evaluation. Collaborate with healthcare teams to enhance patient outcomes while supervising staff...
1 week ago
$150K - $180K *
Join a team that's shaping the future of computer vision by leading our Delivery organization. You'll drive customer success, scale operations, and engage directly in complex implementations, ensuring...
3 weeks ago
Senior Managing Counsel-Pharmacy Network Operations
$197K - $328K *
Shape the future of pharmacy network operations by leading a team of attorneys, providing strategic legal counsel on regulatory, operational, and transactional matters within the PBM landscape, while...
Reposted 6 days ago
National Compliance Consultant - Employee Health & Benefits
$89K - $166K *
Elevate your career as a Compliance Consultant, guiding clients through complex health and welfare benefits laws. Collaborate with experts, deliver training, and develop resources to ensure compliance...
1 week ago
Account Specialist (Peachtree City, GA)
$160K - $192K *
Drive commercial performance by engaging healthcare providers and executing territory plans. Collaborate with cross-functional teams to support product launches and ensure patient access to innovative...
5 days ago
Senior Director, Global Medical Affairs
$177K - $338K *
Innovate the global medical strategy for a leading drug program. Drive launch readiness, evidence generation, and cross-functional partnerships while serving as the primary medical voice in product li...
Reposted 2 weeks ago
$140K - $185K *
Unlock the power of enterprise data as you design and implement Master Data Management solutions that enhance healthcare operations, drive analytics, and enable AI-driven decision-making with trusted...
Reposted 3 weeks ago
Vice President, Revenue Operations
$150K - $175K *
Transform revenue operations by leading systems, data, and processes that unify Sales, Marketing, and Customer Success into a streamlined revenue engine, driving growth and efficiency across the organ...
2 weeks ago
$104K - $156K *
Join us to architect innovative financial systems, leading greenfield projects that enhance data management and analytics. Collaborate across teams to implement your vision and drive impactful solutio...
Today
Senior Advisor, Clinical Science (remote)
$168K - $283K *
Lead the charge in advancing early-stage clinical trials for innovative Orexin-targeted therapies. Collaborate cross-functionally to shape scientific strategy, drive execution, and ensure high-quality...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.