Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$84K - $99K *
Join a dynamic team to evaluate and process medication prior authorization requests, ensuring compliance with clinical guidelines and regulatory standards while facilitating timely patient access to n...
6 days ago
Assistant Director, Global Service Delivery
$100K - $120K *
Advance global service delivery by managing offshore partnerships, ensuring performance excellence, and driving operational improvements across teams to enhance productivity and quality outcomes...
6 days ago
Director of Client Experience, Lab Network
$125K - $160K *
Drive client success in our lab network by managing relationships, ensuring renewals, and identifying growth opportunities. Collaborate across teams to enhance processes and improve client experiences...
1 week ago
$125K - $150K *
Lead the charge in designing and delivering AI applications on Snowflake, optimizing data governance and architecture. Collaborate with clients and engineers to transform concepts into scalable, secur...
1 week ago
$90K - $115K *
Lead the execution and optimization of email and SMS marketing channels, enhancing performance and compliance. Own end-to-end processes, from creative testing to analytics, while collaborating cross-f...
3 weeks ago
Manager, Professional Services Federal
$128K - $160K *
Drive operational excellence and customer satisfaction by managing services teams, optimizing project delivery, and enhancing client engagement strategies for government clients, ensuring alignment wi...
6 days ago
$95K - $115K *
Empower finance leadership with data-driven insights by building models, pipelines, and visualizations. Collaborate across systems to ensure data accuracy and support strategic decision-making in a dy...
4 weeks ago
Director, Cost of Care Solutions
$129K - $162K *
Unlock potential by leading enterprise-wide Cost of Care solutions. Drive scalability, optimize deployment, and enhance operational effectiveness across diverse markets, collaborating with stakeholder...
Reposted 1 week ago
$105K - $130K *
Join a dynamic team to lead multiple client engagements, driving innovative solutions and strategic direction. Foster cross-functional collaboration in a fast-paced environment with a focus on deliver...
Reposted 1 week ago
$262K - $394K *
Accelerate progress at Clio Phones by leading the growth of a cloud-native VoIP platform for law firms. Own P&L, build operational plans, and drive market strategy while managing cross-functional team...
1 week ago
$180K - $220K *
Join a team that's dedicated to transforming patient care through a Whole Health System, managing inpatient medical cases, and collaborating with healthcare professionals to enhance the well-being of...
Yesterday
Senior AI Software Engineer (Healthcare)
$120K - $145K *
Engage in cutting-edge AI development by designing and scaling intelligent applications. Leverage Generative AI and modern tools to enhance productivity and integrate workflows within healthcare platf...
Reposted yesterday
$78K - $128K *
Lead the product lifecycle for health plans, driving strategy, development, and market alignment. Collaborate with cross-functional teams to enhance offerings and ensure compliance, while identifying...
Reposted 2 days ago
$120K - $145K *
Elevate healthcare reimbursement processes by leading legal strategies on billing disputes and regulatory compliance. Collaborate with teams to create innovative solutions and build legal frameworks t...
1 week ago
$180K - $220K *
Engage with cross-functional leaders to elevate product strategy and execution. Drive innovation in product development, leveraging AI to enhance customer value and business performance across a diver...
1 week ago
$101K - $146K *
Unlock potential by leading payer contract negotiations to enhance relationships, optimize revenue, and ensure compliance with regulations, all while aligning with strategic priorities of the health s...
3 weeks ago
Senior Director of Insurance Demand
$160K - $200K *
Join a team that's redefining customer acquisition in the P&C insurance market. Drive strategic partnerships, enhance demand management, and support innovative solutions to elevate our marketplace to...
2 weeks ago
$95K - $115K *
Transform clinical quality by supporting training initiatives, monitoring clinician performance, and ensuring compliance with quality standards for successful operational processes and clinician suppo...
Reposted 1 week ago
Director - Medical - Clinical Research Physician
$201K - $393K *
Lead the development and execution of global clinical trials for women's health compounds, collaborating with cross-functional teams to shape clinical strategies and ensure compliance with regulatory...
Reposted today
$120K - $132K *
Join a team that's dedicated to enhancing cybersecurity measures across cloud environments. Lead initiatives in data protection, compliance, and security awareness while mentoring peers and implementi...
1 week ago
Staff Product Designer, Drafting
$150K - $225K *
Pioneer innovative design solutions as a Staff Product Designer, driving AI-powered workflows and enhancing user experiences in a complex legal tech environment. Collaborate closely with engineering t...
1 week ago
$98K - $125K *
Lead the charge in sourcing and procurement for New Product Introductions, ensuring supplier readiness and cost efficiency. Collaborate with cross-functional teams to drive strategic sourcing initiati...
3 weeks ago
$90K - $110K *
Analyze healthcare data to enhance clinical insights and improve medication use. Collaborate with cross-functional teams to develop analytics tools and real-world evidence studies, driving better heal...
6 days ago
Remote Clinical Psychologist - Older Adults | PhD / PsyD | PSYPACT | Telehealth
$100K - $120K *
Join a team that's redefining telehealth by delivering exceptional psychotherapy to older adults. Enjoy flexible hours, comprehensive support, and opportunities for professional growth while making a...
4 weeks ago
Account Specialists (Covington, LA)
$160K - $192K *
Engage healthcare providers and drive commercial performance in a defined territory. Collaborate with cross-functional teams to support product launches and ensure patient access to innovative therapi...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.