Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Product Designer, Developer Foundations
$180K - $212K *
Lead the design of a comprehensive Developer Portal, enhancing the developer experience through intuitive interfaces and impactful improvements. Collaborate with cross-functional teams to drive user-c...
1 week ago
Enterprise Account Executive, Ohio Valley
$280K - $300K *
Advance your career with a high-impact sales role focused on driving new business and expanding relationships within large enterprise accounts, leveraging cutting-edge AI technology to deliver measura...
3 weeks ago
Senior Director, Customer Support
$155K - $195K *
Manage the transformation of Customer Support into a strategic function, driving operational efficiency and enhancing service quality. Lead a team to implement innovative strategies that elevate the c...
6 days ago
Senior Director, Enterprise Account Management
$160K - $200K *
Transform the enterprise account management landscape by leading strategy, driving revenue retention, fostering customer growth, and developing high-performing teams to enhance client relationships an...
Reposted 4 weeks ago
Senior Software Engineer - Full Stack, Angular, Java, AWS
$128K - $170K *
Advance your career by designing and delivering scalable software solutions. Collaborate with teams to address challenges while enhancing product quality and performance in the healthcare supply chain...
Reposted 4 weeks ago
$100K - $110K *
Drive valuable insights by enhancing Anaplan models and dashboards, collaborating with teams to implement solutions and improve functionality, while supporting users throughout the development lifecyc...
Reposted 2 days ago
$160K - $190K *
Empower your career by partnering with the Science Leadership Team to drive strategic initiatives, enhance operational effectiveness, and translate scientific vision into impactful outcomes across div...
1 week ago
Sr. Strategic Account Executive, MarketScan
$239K - $358K *
Join a team that's committed to maximizing growth in pharmaceutical accounts through strategic planning and relationship building, focusing on data-driven solutions and real-world evidence to foster l...
Reposted 2 weeks ago
$160K - $192K *
Lead the charge in driving commercial performance by engaging healthcare providers, building relationships, and executing territory business plans to ensure patient access to innovative therapies and...
1 week ago
Director, 211 Manufacturing Quality and Regulatory Affairs
$190K - $228K *
Drive enterprise Quality and Regulatory governance for U.S. operations, ensuring compliance with FDA regulations and overseeing manufacturing quality in the therapeutic radiopharmaceutical sector whil...
Reposted 2 weeks ago
Director of Data Analytics and Solutions
$125K - $156K *
Drive data excellence by leading analytics initiatives, enhancing governance, and integrating systems. Collaborate with leadership to deliver impactful insights and ensure compliance while leveraging...
1 week ago
$80K - $95K *
Elevate the patient admission process by leading a dynamic team, ensuring high-quality service, meeting quotas, and implementing best practices. This role is essential in connecting clients with criti...
Reposted 4 weeks ago
Enablement & Engagement Manager, Academic Partnerships
$136K - $204K *
Drive the development of AI and technology certification programs for law schools, enhancing legal education engagement and establishing Clio as a trusted partner in the academic community through inn...
1 week ago
Senior Product Analyst - Employer Health Solutions
$79K - $125K *
Lead the charge in enhancing Employer Health Solutions products, driving market competitiveness through collaboration, strategic analysis, and innovative development. Support regulatory compliance and...
Reposted 6 days ago
Senior Manager Medical Economics - QuickBase Developer
$82K - $182K *
Develop and maintain QuickBase applications while leading complex analytics projects. Ensure data integrity and support clinical performance reporting. Collaborate with stakeholders to drive continuou...
1 week ago
$170K - $185K *
Join a dynamic team to define and lead product strategy for Family Building Navigation, enhancing member engagement through innovative digital experiences and personalized support while collaborating...
5 days ago
Key Account Manager - Chicago, IL
$170K - $205K *
Unlock potential by driving sales strategies for a new kidney transplant product. Collaborate cross-functionally to establish a strong sales foundation, build relationships with healthcare professiona...
3 weeks ago
$110K - $130K *
Unlock potential by leading sales strategies in the renewable energy sector. Collaborate with cross-functional teams to engage clients, driving sales growth and building impactful relationships while...
Reposted 3 weeks ago
$80K - $95K *
Lead the charge in enhancing partnerships within our Collaborative Care Program, focusing on driving referral growth and provider satisfaction through strategic engagement and support at various accou...
1 week ago
$100K - $120K *
Drive the development and integration of advanced nuclear energy systems by applying systems engineering methods to translate objectives into clear, verifiable requirements and solutions, while collab...
1 week ago
Analytics Engineer 5 - Ads Identity & Signals
$330K - $500K+*
Optimize data models and pipelines for identity graph construction, ensuring accurate entity matching and resolution. Collaborate across teams to deliver actionable insights and maintain data quality...
1 week ago
Counsel - Commercial Transactions
$132K - $221K *
Drive enterprise-wide legal support for global contracting activities, focusing on procurement and technology transactions. Collaborate with cross-functional teams to manage risks and ensure complianc...
2 weeks ago
Senior Project Management (Rare/Renal)
$128K - $254K *
Oversee and manage large-scale, multi-national projects, ensuring successful delivery through direct team leadership and cross-functional collaboration, while maintaining high quality and financial pe...
Reposted 1 week ago
Associate Director, Global Revenue, Technical Accounting & Reporting
$177K - $221K *
Champion global revenue accounting policies and lead technical assessments across U.S. and international markets, ensuring compliance with U.S. GAAP and SEC reporting while collaborating with regional...
3 weeks ago
$160K - $200K *
Drive growth and strengthen relationships across community clinics and AICs. Develop new business and expand partnerships while collaborating with key decision-makers in a complex healthcare market. T...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.