Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Internal Medicine Physician - Sioux Falls, SD
$300K *
Unlock potential by delivering expert wound management in a flexible, supportive environment. Enjoy autonomy with no nights, weekends, or call responsibilities while providing care across diverse faci...
3 weeks ago
Sr Editor, Consent Form Development
$66K - $116K *
Elevate your career by joining a team that reviews and edits informed consent forms, ensuring compliance with regulatory standards while mentoring new editors and enhancing organizational knowledge in...
1 week ago
Executive Director of Medical Services
$250K - $275K *
Join us to lead clinical operations for a multi-state virtual care team, ensuring high-quality, timely care. This role combines direct patient care, administrative leadership, and strategic oversight...
6 days ago
Specialty Development Executive - North Central Territory
$130K - $140K *
Help us drive the adoption of innovative colorectal cancer screening solutions by effectively engaging healthcare providers through education, consultation, and strategic support in your assigned terr...
Reposted 2 weeks ago
Manager, Clinical Data Acquisition
$73K - $130K *
Drive the acquisition and usability of clinical data to enhance healthcare outcomes. Collaborate with diverse teams to analyze data gaps, implement integrations, and optimize processes, ensuring timel...
3 weeks ago
$110K - $130K *
Strategize and lead complex technical analysis to bridge business needs with IT solutions, ensuring compliance and efficiency across enterprise operations while mentoring teams and driving continuous...
Yesterday
$150K - $180K *
Transform clinical research practices by guiding study design and analysis. Collaborate with cross-functional teams to deliver key insights and evidence that drive product innovation in the healthcare...
Reposted 5 days ago
Senior Corporate Development and Planning Analyst
$95K - $115K *
Take ownership of financial and operational analysis for strategic initiatives, delivering critical insights and reporting to support executive decision-making while driving accuracy and efficiency in...
Reposted 1 week ago
Regional Sales Director - Milwaukee
$180K - $215K *
Transform your career by leading regional sales efforts for a groundbreaking product. Drive performance, build a high-performing team, and engage with key healthcare providers in a fast-paced, entrepr...
1 week ago
Director, Applications, Lab Systems
$181K - $291K *
Lead the charge in managing the full systems development lifecycle for enterprise applications, ensuring data quality and integrity while evolving best practices across healthcare operations and suppo...
2 days ago
Clinical Sales Specialist, Pulmonary
$110K - $130K *
Unlock your potential by driving sales of innovative pulmonary solutions. Collaborate with diverse stakeholders to enhance patient care and achieve sales targets in a dynamic healthcare environment. J...
Reposted 3 days ago
Physician, Internal Medicine - Telemedicine Opportunity - DrHouse
$210K *
Join a dynamic telemedicine team to deliver high-quality, patient-centered care across South Dakota. Enjoy flexible scheduling while managing diverse clinical cases, including primary and urgent care...
1 week ago
$170K - $185K *
Elevate user experiences by leading the design of complex healthcare applications. Collaborate with cross-functional teams to create intuitive interfaces that enhance clinical workflows and support hi...
3 weeks ago
Medical Specialist I Pulmonology Los Angeles East
$140K - $190K *
Join a team that's dedicated to driving revenue growth in the Pulmonary sector by engaging healthcare professionals and implementing strategic initiatives to enhance product utilization and foster str...
3 weeks ago
$85K - $100K *
Drive comprehensive audits, mentor junior staff, and ensure compliance with clinical and financial standards. Enhance revenue cycle performance by identifying issues and recommending improvements, whi...
1 month ago
Account Director, Promotional Medical Education
$100K - $120K *
Partner with us to drive strategic healthcare marketing initiatives. Lead client relationships, oversee peer-to-peer programs, and mentor team members to ensure compliance and achieve results while fo...
Reposted 1 week ago
$119K - $179K *
Lead the charge in architecting FHIR-compliant data models to enhance clinical data integration and usability, supporting patient care and research initiatives across the organization...
3 weeks ago
$190K - $230K *
Lead the accounting and financial reporting functions within a growing healthcare organization. Drive integrity across multiple entities, ensure compliance, and strategize cash management while suppor...
Reposted today
Senior Scientist, Safety Assessment and Investigative Toxicology
$66K - $189K *
Innovate analytical strategies to enhance toxicology assessments, ensuring compliance and data integrity. Collaborate across teams to drive project success and influence decision-making through advanc...
3 days ago
Director, Medical - Clinical Research Scientist
$177K - $338K *
Help us advance women's health through innovative clinical trial strategies, where you will conduct, support, and report on global studies for cutting-edge compounds, ensuring adherence to regulatory...
Reposted 1 week ago
Clinical Applications Specialist, Invasive Cardiology - Houston, TX
$90K - $110K *
Champion clinical education and training by delivering expert knowledge and support to enhance user competencies and optimize patient care within a defined territory. Build strong relationships with s...
6 days ago
Associate General Counsel - Clinical & Commercial - CRO Services
$170K - $200K *
Unlock potential by providing strategic legal counsel on clinical and commercial operations, focusing on regulatory compliance, privacy, and data protection in a dynamic biopharmaceutical environment...
Reposted 5 days ago
$140K - $270K *
Unlock your potential as a Research Scientist, driving AI innovations in healthcare. Collaborate with cross-functional teams to develop and implement cutting-edge machine learning models that enhance...
Reposted 2 weeks ago
Senior Advisor, Clinical Pharmacology
$153K - $268K *
Join our team to provide expert clinical pharmacology insights, driving dose selection and study design for innovative therapies. Collaborate with cross-functional teams to translate complex data into...
1 week ago
$95K - $115K *
Unlock the potential of implementation science as a Senior Program Analyst, driving quality improvement and program evaluation initiatives. Manage processes, databases, and reporting to enhance projec...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.