Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Anesthesiologist Jobs in South Dakota

Sort By: Relevance

$78K - $128K *

Lead the product lifecycle for health plans, driving strategy, development, and market alignment. Collaborate with cross-functional teams to enhance offerings and ensure compliance, while identifying...

RemoteRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Healthcare

$70K - $99K *

Empower your career by delivering personalized nursing care in a top-rated facility. Utilize your expertise to collaborate with a dedicated team, ensuring excellence in resident care and rehabilitatio...

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Champion healthcare solutions by managing integrations and providing expert support. Drive projects and improve processes as a Senior Interface Analyst in a dynamic and innovative environment, ensurin...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$157K - $174K *

Elevate technical execution in GMP manufacturing by leading complex workstreams for comparability strategies, tech transfers, and process improvements. Collaborate with cross-functional teams to ensur...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$91K - $145K *

Shape the future of data solutions by leading complex pharmacy claims and physician-level data integrations. Collaborate with cross-functional teams to deliver high-quality, scalable solutions that me...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$215K - $235K *

Advance drug substance development and drive clinical readiness projects by leading process chemistry initiatives, collaborating with cross-functional teams, and ensuring regulatory compliance for suc...

United StatesRemote

Reposted 3 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$85K - $102K *

Drive program success by integrating technical, operational, and business teams to exceed customer expectations and manage all aspects of project performance, cost, and timelines for complex radar and...

Reposted yesterday

  •   5 - 7 years exp.  •   Aerospace & Defense

$195K - $265K *

Transform global marketing strategies in oncology by leading cross-functional teams, driving insights, and optimizing brand value for pipeline assets. Collaborate with stakeholders to enhance commerci...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$84K - $126K *

Lead the charge in enhancing patient care through effective utilization review, ensuring quality and compliance while collaborating with healthcare teams to optimize clinical outcomes and financial pe...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$83K - $107K *

Elevate digital strategies by integrating user experience with data-driven insights. Collaborate to enhance our online presence, optimize content, and ensure consistency across digital platforms to cr...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$89K - $166K *

Elevate your career as a Compliance Consultant, guiding clients through complex health and welfare benefits laws. Collaborate with experts, deliver training, and develop resources to ensure compliance...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$150K - $175K *

Accelerate growth through strategic demand generation and integrated marketing campaigns. Collaborate with Sales and Product teams to optimize the pipeline, drive revenue, and enhance customer engagem...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$134K - $162K *

Contribute to the advancement of medical physics by leading dosimetry analysis for radiopharmaceuticals. Collaborate with cross-functional teams to drive research in drug development and improve imagi...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$82K - $150K *

Drive growth by aggressively prospecting and converting new dental accounts while expanding existing relationships. Utilize a hunter mentality to identify opportunities and position value-oriented imp...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$82K - $150K *

Accelerate growth by driving new customer acquisition and expanding market share in the dental implant sector. Leverage your sales expertise to build relationships, convert competitive accounts, and p...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$82K - $150K *

Drive growth by aggressively prospecting and converting new dental implant accounts. Leverage a hunter mentality to expand market share, build relationships, and position value-oriented solutions with...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$82K - $150K *

Accelerate growth by driving new customer acquisition and expanding market share in the dental implant sector. Leverage a hunter mentality to convert competitive accounts and position value-oriented s...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$82K - $150K *

Accelerate your career by driving growth in the dental implant market. Leverage your sales expertise to open new accounts, convert competitive users, and expand market share while delivering value-ori...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$82K - $150K *

Elevate sales growth by aggressively prospecting and converting new dental implant accounts. Focus on expanding market share and positioning value-driven solutions while collaborating with internal te...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$82K - $150K *

Transform your career by driving growth in the dental implant market. Leverage your sales expertise to open new accounts, convert competitive users, and expand market share while delivering value-orie...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$141K - $196K *

Unlock potential by developing causal machine-learning models to optimize customer offers, analyzing complex data, and translating findings into actionable strategies for enhanced conversion rates acr...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$99K - $136K *

Pioneer strategic growth in Hemostasis solutions, driving revenue and market share expansion through complex sales engagements and executive relationships across healthcare systems and laboratories...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$82K - $150K *

Elevate your career by driving growth in the dental implant market. This role focuses on acquiring new customers, expanding market share, and positioning value-driven solutions, requiring a proactive...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $150K *

Drive sales growth and platform adoption by executing strategic marketing initiatives, collaborating across teams, and leveraging customer insights to enhance product positioning and sales enablement...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Energy & Utilities

$90K - $110K *

Advance quality assurance efforts by designing and executing tests for backend systems and APIs, ensuring data integrity and performance across cloud environments. Collaborate with engineers to enhanc...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.