Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Group Manager, Customer Success
$134K - $184K *
Shape the future of customer success by leading a high-performing team, optimizing operations, and driving engagement and retention strategies to achieve key performance indicators and enhance client...
2 weeks ago
Manager, Clinical Lab Project Management
$114K - $187K *
Champion clinical laboratory operations by managing complex projects, ensuring timely study starts, and collaborating with cross-functional teams to deliver impactful results in precision medicine...
3 weeks ago
Sr Global Product Manager, Digital Solutions - Surgical & Procedural Care
$149K - $224K *
Lead the charge in shaping digital solutions for perioperative workflows, driving strategy and execution across cross-functional teams to enhance clinical outcomes and operational efficiency in surgic...
6 days ago
Clinical Science Liaison (CSL)
$150K - $180K *
Innovate healthcare delivery by serving as a clinical liaison, translating partner needs into actionable insights for chronic care and telehealth programs, impacting thousands of patients nationwide t...
3 weeks ago
Senior Compliance Analyst - Advertising Review
$85K - $100K *
Champion compliance excellence by reviewing retail communications to ensure adherence to regulations and firm policies. Collaborate with teams to maintain high standards and support organizational goa...
1 week ago
Training Manager, Field Access & Reimbursement
$124K - $135K *
Shape impactful training programs for Field Access teams, enhancing access and reimbursement capabilities across therapeutic areas. Collaborate with stakeholders to ensure compliance and relevance, fo...
2 days ago
Clinical Documentation Integrity Supervisor
$110K - $159K *
Inspire excellence in clinical documentation by leading a team of specialists, ensuring quality assurance, and fostering professional development. Collaborate with stakeholders to enhance operational...
Reposted today
Clinical Documentation Integrity Supervisor
$110K - $159K *
Empower the Clinical Documentation Integrity team by ensuring staff competency through quality assurance, training, and performance management. Collaborate on action plans and foster associate develop...
2 days ago
Clinical Documentation Integrity Supervisor
$110K - $159K *
Lead the charge in enhancing clinical documentation integrity by supervising staff, conducting quality reviews, and fostering professional development. Collaborate with teams to implement effective st...
2 weeks ago
Regulatory and Legal Operations Manager
$110K - $130K *
Optimize regulatory compliance and legal operations in healthcare. Collaborate with cross-functional teams to ensure adherence to industry standards while driving efficiency and effectiveness in legal...
Yesterday
$195K - $277K *
Drive innovative clinical oncology studies by designing protocols, collaborating with teams, and ensuring compliance with regulations. Leverage expertise to analyze data, support publications, and mai...
3 weeks ago
Manager, Commercial Education- Trauma & Extremities
$102K - $177K *
Transform the sales training landscape by designing and executing innovative educational programs for Trauma & Extremities, enhancing team competency and driving strategic growth in alignment with glo...
Reposted 2 days ago
Director, Health Systems Partnerships
$190K - $240K *
Elevate healthcare impact by building and scaling enterprise accounts in women's health. Own the sales cycle, engage stakeholders, and drive screening initiatives while collaborating across teams to e...
Reposted 4 weeks ago
$77K - $110K *
Empower the President of Global Solutions by delivering exceptional administrative support, managing complex schedules, coordinating travel, and facilitating effective communication across teams to en...
Today
Software Architect (AWS/Azure)
$101K - $135K *
Join a team that's shaping the future of healthcare technology by designing and enhancing our build and delivery infrastructure. Collaborate with architects and developers to implement best practices...
1 week ago
NeuroPsych Account Specialist - Hawaii HI
$123K - $168K *
Explore the potential of Neurocrine products by managing key accounts, driving sales growth, and fostering relationships with healthcare professionals. Collaborate cross-functionally to enhance produc...
3 weeks ago
Senior Consultant - HHS Collaboratives
$90K - $150K *
Join a dynamic team to leverage clinical expertise in healthcare consulting, driving improvements in perinatal care and women's health. Collaborate with leaders to analyze data, share best practices...
Today
Healthcare Claims Payment Policy Managing Consultant
$113K - $188K *
Shape the future of healthcare reimbursement by developing and implementing payment policies that enhance accuracy, compliance, and provider experience in a dynamic payer environment. Collaborate with...
2 weeks ago
Senior Oncology Account Manager, Omaha
$150K - $230K *
Transform the future of oncology care by driving product success and building strong relationships with key stakeholders. Lead initiatives that enhance patient access and deliver innovative solutions...
1 week ago
$158K - $185K *
Join a dynamic team dedicated to revolutionizing cardiac health through innovative sales leadership. Guide a team of Territory Managers, driving revenue growth and operational excellence across a desi...
Reposted 5 days ago
$135K - $160K *
Lead a dynamic team to transform AI strategies into impactful healthcare solutions. Oversee engineering execution, guide architecture, and ensure compliance while collaborating with cross-functional p...
Today
R&D Supplier Quality Sr Manager
$132K - $178K *
Shape the future of quality management by overseeing GxP suppliers in R&D. Drive risk-based assessments and foster cross-functional collaboration to ensure compliance and operational excellence in cli...
2 weeks ago
Patient Programming / Ambassador Manager
$205K - $228K *
Champion patient-focused initiatives by leading strategy and execution of ambassador programs. Build relationships with patients and advocacy groups to enhance engagement and ensure their voices shape...
1 week ago
Director, 503A Provider Relations
$110K - $130K *
Drive growth by leading a team of provider relations representatives, managing key provider relationships, and implementing strategies to enhance service offerings and revenue within the compounding p...
4 weeks ago
$150K - $180K *
Empower medical initiatives by leading project teams, providing strategic guidance, and ensuring compliance with regulatory standards while fostering high-performing teams in a dynamic environment...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.