Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Anesthesiologist Jobs in South Dakota

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$90K - $105K *

Join a team that's dedicated to enhancing system reliability and performance for critical defense projects. Leverage your engineering expertise to implement best practices and drive data-driven improv...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$120K - $145K *

Shape complex, cross-functional programs that drive enterprise transformation, focusing on Customer Data Platform implementation and AI initiatives. Collaborate with diverse teams to ensure strategic...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $180K *

Explore opportunities as a Senior Security Engineer, safeguarding the DeFi ecosystem by identifying vulnerabilities, enhancing monitoring tools, and ensuring compliance with security protocols. Collab...

RemoteRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $180K *

Lead the future of patient experience by driving strategic initiatives and operational excellence in a high-volume healthcare contact center. Collaborate with cross-functional teams to enhance service...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Healthcare

$135K - $165K *

Pioneer operational excellence in Design leadership, managing workflows, prioritizing projects, and developing talent. Collaborate cross-functionally to enhance Design integration in AI-driven product...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Lead the compliance and documentation efforts, ensuring robust privacy and security practices. Collaborate across teams to create and maintain essential documentation, audits, and operational workflow...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$134K - $219K *

Lead clinical laboratory operations for precision medicine projects, ensuring timely deliverables and risk management across therapeutic areas. Collaborate with cross-functional teams to support clini...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$90K - $100K *

Join a team that's redefining accounting excellence by managing month-end closes, revenue recognition, and international audits. Leverage your CPA expertise to enhance financial integrity and drive pr...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $230K *

Unlock potential by driving oncology product success through strategic relationships and innovative solutions. Lead efforts to enhance patient access and exceed performance goals while navigating a co...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$125K - $235K *

Drive operational excellence in healthcare by leading transformative initiatives, optimizing workflows, and enhancing provider productivity. Collaborate with teams to deliver data-driven solutions tha...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$112K - $131K *

Elevate your career by leading complex financial analyses and strategic initiatives. As a senior contributor, you'll drive enhancements in reporting, support business decisions, and mentor team member...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$90K - $110K *

Drive AI transformation by mapping current processes and designing future-state models across G&A functions. Collaborate with stakeholders to identify automation opportunities and enhance operational...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$160K - $192K *

Join a dynamic team to drive commercial performance and enhance patient access through strong relationships with healthcare providers, executing strategic business plans and supporting innovative prod...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Transform energy solutions by leading diverse projects, conducting analyses, and collaborating with clients. Utilize engineering expertise to drive efficiency and sustainability in various sectors, en...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Engineer advanced protein design models and collaborate with experts to innovate in AI Drug Discovery, driving the development of candidate antibody therapeutics through deep learning and systems biol...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$75K - $105K *

Collaborate with clients to enhance their social media strategies using healthcare insights, data-driven execution, and creative content development for multi-channel success. This role demands a proa...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$104K - $174K *

Unlock potential by driving client engagement and delivering tailored solutions. Collaborate with cross-functional teams to enhance client experiences, manage complex projects, and present insights to...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$134K - $179K *

Lead the charge in bridging genomic variants with clinical insights, collaborating with scientists to automate and scale curation workflows. Drive innovation in AI/ML applications while ensuring softw...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$225K - $281K *

Lead the charge in shaping detection and response strategies, driving hands-on initiatives to enhance security architecture and incident management. Collaborate across teams to ensure robust threat de...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Join a team that's driving innovation in transplant advocacy by integrating business development, marketing, and medical expertise. Collaborate with key stakeholders to enhance KOL engagement and mark...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$63K - $96K *

Engage in the support and optimization of multi-user operating systems and applications, collaborating with users and IT teams to enhance system functionality and ensure effective use of technology ac...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Champion the end-to-end management of complex healthcare programs, ensuring operational readiness and compliance. Collaborate with teams and clients to drive successful implementations while maintaini...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead complex healthcare project initiatives, ensuring successful implementation and operational readiness while maintaining high standards of governance. Foster strong partnerships with clients, manag...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Unlock potential by mentoring new providers through virtual education, ensuring a seamless onboarding experience. Leverage your clinical expertise to foster growth in both primary care and behavioral...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$272K - $340K *

Join a team that's driving CMC strategy and execution for innovative therapies. Lead cross-functional efforts in drug and device development, ensuring compliance and operational excellence from clinic...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.