Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$90K - $105K *
Join a team that's dedicated to enhancing system reliability and performance for critical defense projects. Leverage your engineering expertise to implement best practices and drive data-driven improv...
2 weeks ago
Staff Technical Program Manager, Enterprise Transformation
$120K - $145K *
Shape complex, cross-functional programs that drive enterprise transformation, focusing on Customer Data Platform implementation and AI initiatives. Collaborate with diverse teams to ensure strategic...
1 week ago
Senior Security Engineer, DeFi
$150K - $180K *
Explore opportunities as a Senior Security Engineer, safeguarding the DeFi ecosystem by identifying vulnerabilities, enhancing monitoring tools, and ensuring compliance with security protocols. Collab...
Reposted 4 weeks ago
Senior Director, Contact Center
$150K - $180K *
Lead the future of patient experience by driving strategic initiatives and operational excellence in a high-volume healthcare contact center. Collaborate with cross-functional teams to enhance service...
Reposted yesterday
$135K - $165K *
Pioneer operational excellence in Design leadership, managing workflows, prioritizing projects, and developing talent. Collaborate cross-functionally to enhance Design integration in AI-driven product...
1 week ago
Compliance and Documentation Lead
$110K - $130K *
Lead the compliance and documentation efforts, ensuring robust privacy and security practices. Collaborate across teams to create and maintain essential documentation, audits, and operational workflow...
4 weeks ago
Senior Manager, Clinical Lab Project Management
$134K - $219K *
Lead clinical laboratory operations for precision medicine projects, ensuring timely deliverables and risk management across therapeutic areas. Collaborate with cross-functional teams to support clini...
3 weeks ago
$90K - $100K *
Join a team that's redefining accounting excellence by managing month-end closes, revenue recognition, and international audits. Leverage your CPA expertise to enhance financial integrity and drive pr...
2 weeks ago
Senior Oncology Account Manager, Fort Myers
$150K - $230K *
Unlock potential by driving oncology product success through strategic relationships and innovative solutions. Lead efforts to enhance patient access and exceed performance goals while navigating a co...
1 week ago
Strategy and Operations Physician Enterprise Clinical SME
$125K - $235K *
Drive operational excellence in healthcare by leading transformative initiatives, optimizing workflows, and enhancing provider productivity. Collaborate with teams to deliver data-driven solutions tha...
6 days ago
$112K - $131K *
Elevate your career by leading complex financial analyses and strategic initiatives. As a senior contributor, you'll drive enhancements in reporting, support business decisions, and mentor team member...
3 weeks ago
$90K - $110K *
Drive AI transformation by mapping current processes and designing future-state models across G&A functions. Collaborate with stakeholders to identify automation opportunities and enhance operational...
1 week ago
Account Specialist (Evansville, IN)
$160K - $192K *
Join a dynamic team to drive commercial performance and enhance patient access through strong relationships with healthcare providers, executing strategic business plans and supporting innovative prod...
1 week ago
$80K - $95K *
Transform energy solutions by leading diverse projects, conducting analyses, and collaborating with clients. Utilize engineering expertise to drive efficiency and sustainability in various sectors, en...
3 weeks ago
Staff/Principal AI Scientist - Virtual Tissue
$150K - $180K *
Engineer advanced protein design models and collaborate with experts to innovate in AI Drug Discovery, driving the development of candidate antibody therapeutics through deep learning and systems biol...
Reposted 1 week ago
$75K - $105K *
Collaborate with clients to enhance their social media strategies using healthcare insights, data-driven execution, and creative content development for multi-channel success. This role demands a proa...
Reposted 1 week ago
$104K - $174K *
Unlock potential by driving client engagement and delivering tailored solutions. Collaborate with cross-functional teams to enhance client experiences, manage complex projects, and present insights to...
3 weeks ago
Staff Bioinformatics Engineer, Clinical Applications
$134K - $179K *
Lead the charge in bridging genomic variants with clinical insights, collaborating with scientists to automate and scale curation workflows. Drive innovation in AI/ML applications while ensuring softw...
1 week ago
Staff Engineer, Detection and Response
$225K - $281K *
Lead the charge in shaping detection and response strategies, driving hands-on initiatives to enhance security architecture and incident management. Collaborate across teams to ensure robust threat de...
1 week ago
Clinical Liaison and Market Dev. Leader
$110K - $130K *
Join a team that's driving innovation in transplant advocacy by integrating business development, marketing, and medical expertise. Collaborate with key stakeholders to enhance KOL engagement and mark...
3 weeks ago
$63K - $96K *
Engage in the support and optimization of multi-user operating systems and applications, collaborating with users and IT teams to enhance system functionality and ensure effective use of technology ac...
Yesterday
Senior Project Manager - U.S. Healthcare Programs
$110K - $130K *
Champion the end-to-end management of complex healthcare programs, ensuring operational readiness and compliance. Collaborate with teams and clients to drive successful implementations while maintaini...
Yesterday
Senior Project Manager - U.S. Healthcare Programs
$110K - $130K *
Lead complex healthcare project initiatives, ensuring successful implementation and operational readiness while maintaining high standards of governance. Foster strong partnerships with clients, manag...
Reposted 3 weeks ago
Behavioral Health Virtual Preceptor - Nurse Practitioner or Physician Assistant
$100K - $120K *
Unlock potential by mentoring new providers through virtual education, ensuring a seamless onboarding experience. Leverage your clinical expertise to foster growth in both primary care and behavioral...
2 weeks ago
Vice President, CMC Development and Drug Delivery Innovation
$272K - $340K *
Join a team that's driving CMC strategy and execution for innovative therapies. Lead cross-functional efforts in drug and device development, ensuring compliance and operational excellence from clinic...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.