Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Director, Regulatory Affairs
$211K - $281K *
Champion regulatory excellence by leading U.S. FDA engagement and strategy for product development, ensuring timely approvals and compliance while driving cross-functional collaboration and organizati...
3 weeks ago
Director of Growth Marketing & Analytics
$155K - $192K *
Lead the charge in transforming member acquisition strategies through data-driven insights, optimizing marketing performance, and driving sustainable growth in a fully remote environment. Collaborate...
1 week ago
$93K - $104K *
Unlock potential by joining our team of dedicated Registered Nurses, providing essential care in diverse settings. Enjoy flexible scheduling, competitive pay, and the opportunity to make a meaningful...
Yesterday
$93K - $104K *
Join a team that's dedicated to providing exceptional patient care while enjoying flexible scheduling options. As a Registered Nurse, you'll play a vital role in assessing and supporting patients in v...
Yesterday
Account Executive - Business Development Sales, Healthcare SaaS
$150K - $180K *
Advance healthcare solutions by building executive relationships and driving enterprise sales. Lead the sales lifecycle, develop strategic accounts, and leverage modern tools to optimize revenue growt...
Today
Patient Advocacy Liaison (Central Region)
$150K - $175K *
Lead community engagement initiatives to enhance patient advocacy for Becker Muscular Dystrophy. Collaborate with local organizations, educate patients, and build networks to ensure access to quality...
Today
Perinatal Mental Health Therapist (Remote)
$80K - $85K *
Lead transformative maternal mental health initiatives by providing evidence-based therapy, collaborating with interdisciplinary teams, and advocating for client needs to enhance program effectiveness...
2 weeks ago
$110K *
Take ownership of complex mortgage loan evaluations, ensuring compliance with guidelines while assessing borrower risk. Collaborate with internal teams and vendors to facilitate loan approvals and mai...
1 week ago
Senior Faculty Development Specialist - AIUS Online (Remote)
$80K - $95K *
Champion faculty success by developing and delivering innovative professional learning programs. Collaborate with stakeholders to enhance instructional quality and faculty engagement while ensuring al...
Reposted 1 week ago
$100K - $125K *
Lead and manage diverse acoustics projects, mentoring team members while collaborating with top engineers and architects on high-impact designs across various sectors, including healthcare, education...
2 weeks ago
$190K - $300K *
Champion scientific exchange and clinical research in Cardiovascular & Metabolism. Engage with medical leaders, enhance understanding of research goals, and gather insights to drive strategic initiati...
1 week ago
Senior Oncology Account Manager, Manhattan
$150K - $230K *
Join a team that's dedicated to advancing oncology care by promoting innovative treatments, building strong relationships with healthcare professionals, and driving patient access to essential therapi...
1 week ago
$137K - $185K *
Drive the execution of complex projects, ensuring alignment across global teams. Collaborate with stakeholders to manage risks, track progress, and deliver key medical strategies while fostering cross...
3 days ago
Enterprise Account Executive - Healthcare Payors
$105K - $127K *
Champion growth by driving enterprise sales in healthcare payors, leveraging SaaS solutions to enhance client experiences. Build relationships, negotiate contracts, and exceed quotas while collaborati...
2 weeks ago
Product Sales Specialist, Diagnostic Cardiology - IN, OH, KY
$80K - $95K *
Drive sales strategy for Diagnostic Cardiology and Vital Signs Monitors in the Indiana, Ohio, and Kentucky territory. Collaborate with teams to enhance customer support and leverage market insights fo...
3 weeks ago
$150K - $165K *
Engage clients by driving revenue through consultative sales, building strong relationships with law firms and corporations. Leverage industry insights to anticipate needs and deliver tailored solutio...
2 weeks ago
Assistant Superintendent- Special Projects
$80K - $95K *
Unlock your potential as a key player in our Special Projects Division, driving construction excellence through effective planning, communication, and safety compliance while managing project schedule...
2 weeks ago
Senior / Global Regulatory Labeling Strategist
$125K - $150K *
Champion global labeling strategy for innovative therapies, leading complex initiatives from development to post-approval. Collaborate with cross-functional teams to ensure compliance and high-quality...
2 weeks ago
Customer Education Manager - West Coast
$105K - $130K *
Join a team that's dedicated to enhancing customer education through training, demonstrations, and support. Drive regional sales strategies while fostering relationships and improving the overall cust...
1 week ago
Associate Director, Strategic Accounts (New England)
$135K - $160K *
Unlock potential by leading a dynamic sales team in hematology, driving strategic account management and fostering key stakeholder relationships to enhance the clinical experience with ZYNLONTA across...
1 week ago
Senior Oncology Account Manager, Seattle
$150K - $230K *
Accelerate progress at Revolution Medicines by driving oncology product sales, building strong relationships with healthcare professionals, and ensuring patient access to innovative therapies in a dyn...
1 week ago
$68K - $105K *
Champion the implementation and support of Epic Beaker applications, ensuring effective system design, user experience, and problem resolution while managing projects and enhancing end-user engagement...
3 weeks ago
$190K - $200K *
Elevate your career by driving sales strategy and execution for a dynamic SaaS portfolio. Lead a high-performing team to achieve revenue growth, optimize pipeline management, and enhance customer acqu...
1 week ago
$80K - $95K *
Transform mortgage servicing by leading policy development, ensuring compliance, and enhancing documentation processes. Collaborate cross-functionally to identify gaps and implement effective governan...
4 weeks ago
Medical Science Liaison, New England
$120K - $145K *
Engage healthcare professionals and thought leaders by driving scientific discussions, supporting clinical research, and facilitating impactful medical strategies in the rare disease liver portfolio w...
Reposted 4 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.