Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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Anesthesiologist Jobs in South Dakota

Sort By: Relevance

$200K - $250K *

Make your mark at the forefront of clinical operations, driving global studies from strategy to execution while ensuring operational integration across teams and vendors for successful Phase 3 program...

United StatesRemote

1 month ago

  •   15+ years exp.  •   Pharmaceuticals & Biotech

$175K - $200K *

Lead the charge in optimizing biomarker program operations, ensuring seamless sample processing from collection to storage. Collaborate across teams to uphold quality and compliance while driving grow...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$95K - $115K *

Build strong relationships and drive sales for advanced wound care products in a defined territory. Achieve revenue targets through strategic planning, customer engagement, and exceptional service in...

RemoteRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K *

Empower clients by managing complex care needs through remote case management, ensuring access to high-quality treatment and support. Collaborate with multidisciplinary teams to enhance client engagem...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $105K *

Collaborate with clients and teams to manage projects, expectations, and delivery, ensuring high standards and strategic growth in a fast-paced medical affairs environment. Leverage experience to iden...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$210K *

Unlock potential by delivering high-quality virtual care as a board-certified OB/GYN. Manage diverse clinical cases through telehealth, ensuring patient-centered treatment while enjoying a flexible sc...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$210K *

Shape the future of telehealth by delivering compassionate, patient-centered care. Join a dynamic team of board-certified OB/GYN physicians providing virtual consultations across South Dakota, balanci...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Join a dynamic team to lead and scale clinical operations, overseeing performance and process optimization. Build accountable teams, manage metrics, and partner with stakeholders to enhance operationa...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$160K - $200K *

Drive strategic growth and business development for National Accounts in Urology and Oncology, optimizing resources and leading negotiations to enhance healthcare outcomes through innovative diagnosti...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Drive data integrity and operational excellence by resolving complex payer data issues, collaborating across teams, and enhancing data quality for value-based care initiatives. Play a key role in opti...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Lead the charge in developing and overseeing scientific content across multiple therapeutic areas, ensuring high-quality contributions and strategic client interactions to drive growth and innovation...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$90K - $110K *

Elevate cardiovascular care by collaborating with healthcare teams to provide comprehensive assessments, treatment plans, and follow-up for patients in both outpatient and inpatient settings, ensuring...

4 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$160K - $200K *

Lead the charge in medical oversight for clinical trials, ensuring high standards and executing timelines. Collaborate with cross-functional teams to enhance trial protocols and contribute to impactfu...

RemoteRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$172K - $223K *

Champion operational excellence as a strategic leader, driving performance and financial results across the PacWest Region while ensuring safety, quality, and compliance in a mission-driven environmen...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Healthcare

$210K - $250K *

Contribute to a patient-focused care environment by managing evaluations, diagnoses, and treatments. Collaborate within a multidisciplinary team to promote health education and ensure quality care ali...

Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Elevate your career by managing clinical sites and ensuring study quality, patient safety, and regulatory compliance. Collaborate with site teams to support enrollment and deliver impactful clinical r...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$140K - $190K *

Unlock your potential by engaging key Gastroenterology stakeholders, driving product utilization, and exceeding sales goals through strategic collaboration and compliance in a dynamic healthcare envir...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $90K *

Champion project success by managing timelines, resources, and stakeholder communication. Drive seamless implementation experiences while collaborating with cross-functional teams to deliver value-dri...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$350K - $398K *

Drive impactful clinical trials in ophthalmology with leadership in study design, execution, and biomarker strategy. Collaborate cross-functionally to ensure timely delivery and regulatory compliance...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$92K - $138K *

Join a dynamic team to deliver clinical education and support for diagnostic cardiology solutions, enhancing customer experience and driving successful outcomes through expert training and collaborati...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Business Services

$80K - $95K *

Empower our analyst relations program by managing evaluations, timelines, and coordination. Collaborate with stakeholders to ensure accurate, timely engagement and support market insights for strategi...

United StatesRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$189K - $246K *

Lead clinical pharmacology strategies, integrating PK/PD assessments across development phases. Collaborate with cross-functional teams to guide decision-making and regulatory submissions, ensuring al...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$210K - $250K *

Unlock potential by leveraging your GI expertise to enhance product development, strengthen customer relationships, and drive growth in a dynamic SaaS environment. Collaborate across teams to deliver...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Support clinical studies by assisting teams with tasks like medical monitoring and protocol management. Collaborate across functions and engage with stakeholders to ensure successful trial outcomes wh...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$87K - $151K *

Unlock potential by providing expert remote clinical applications support for advanced molecular imaging. Leverage your clinical knowledge and customer service skills to enhance productivity and deliv...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.