Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Vice President, Clinical Operations
$200K - $250K *
Make your mark at the forefront of clinical operations, driving global studies from strategy to execution while ensuring operational integration across teams and vendors for successful Phase 3 program...
1 month ago
Operations Director, Biomarker Programs
$175K - $200K *
Lead the charge in optimizing biomarker program operations, ensuring seamless sample processing from collection to storage. Collaborate across teams to uphold quality and compliance while driving grow...
2 weeks ago
Account Manager, Wound Reconstruction Solutions -- Los Angeles, CA
$95K - $115K *
Build strong relationships and drive sales for advanced wound care products in a defined territory. Achieve revenue targets through strategic planning, customer engagement, and exceptional service in...
Reposted 2 days ago
$80K *
Empower clients by managing complex care needs through remote case management, ensuring access to high-quality treatment and support. Collaborate with multidisciplinary teams to enhance client engagem...
2 weeks ago
Senior Account Manager, Med Affairs
$90K - $105K *
Collaborate with clients and teams to manage projects, expectations, and delivery, ensuring high standards and strategic growth in a fast-paced medical affairs environment. Leverage experience to iden...
Reposted 1 week ago
Physician, OB/GYN - Telemedicine Opportunity - DrHouse
$210K *
Unlock potential by delivering high-quality virtual care as a board-certified OB/GYN. Manage diverse clinical cases through telehealth, ensuring patient-centered treatment while enjoying a flexible sc...
2 days ago
Physician, OB/GYN - Telemedicine Opportunity - DrHouse
$210K *
Shape the future of telehealth by delivering compassionate, patient-centered care. Join a dynamic team of board-certified OB/GYN physicians providing virtual consultations across South Dakota, balanci...
2 days ago
$150K - $180K *
Join a dynamic team to lead and scale clinical operations, overseeing performance and process optimization. Build accountable teams, manage metrics, and partner with stakeholders to enhance operationa...
Reposted 4 weeks ago
National Director, Integrated Specialty Practices
$160K - $200K *
Drive strategic growth and business development for National Accounts in Urology and Oncology, optimizing resources and leading negotiations to enhance healthcare outcomes through innovative diagnosti...
3 weeks ago
$80K - $95K *
Drive data integrity and operational excellence by resolving complex payer data issues, collaborating across teams, and enhancing data quality for value-based care initiatives. Play a key role in opti...
4 weeks ago
Senior Scientific Director (Rare/Neurology/Psychiatry)
$150K - $180K *
Lead the charge in developing and overseeing scientific content across multiple therapeutic areas, ensuring high-quality contributions and strategic client interactions to drive growth and innovation...
4 weeks ago
Nurse Practitioner/Physician Assistant - Cardiology
$90K - $110K *
Elevate cardiovascular care by collaborating with healthcare teams to provide comprehensive assessments, treatment plans, and follow-up for patients in both outpatient and inpatient settings, ensuring...
4 weeks ago
Clinical Study Physician - Oncology - FSP
$160K - $200K *
Lead the charge in medical oversight for clinical trials, ensuring high standards and executing timelines. Collaborate with cross-functional teams to enhance trial protocols and contribute to impactfu...
Reposted 2 days ago
Vice President Field Operations
$172K - $223K *
Champion operational excellence as a strategic leader, driving performance and financial results across the PacWest Region while ensuring safety, quality, and compliance in a mission-driven environmen...
1 week ago
$210K - $250K *
Contribute to a patient-focused care environment by managing evaluations, diagnoses, and treatments. Collaborate within a multidisciplinary team to promote health education and ensure quality care ali...
Reposted yesterday
$80K - $95K *
Elevate your career by managing clinical sites and ensuring study quality, patient safety, and regulatory compliance. Collaborate with site teams to support enrollment and deliver impactful clinical r...
Today
$140K - $190K *
Unlock your potential by engaging key Gastroenterology stakeholders, driving product utilization, and exceeding sales goals through strategic collaboration and compliance in a dynamic healthcare envir...
4 weeks ago
$80K - $90K *
Champion project success by managing timelines, resources, and stakeholder communication. Drive seamless implementation experiences while collaborating with cross-functional teams to deliver value-dri...
3 weeks ago
Executive Medical Director (Retina Program)
$350K - $398K *
Drive impactful clinical trials in ophthalmology with leadership in study design, execution, and biomarker strategy. Collaborate cross-functionally to ensure timely delivery and regulatory compliance...
Reposted 3 weeks ago
Clinical Application Specialist - DCAR
$92K - $138K *
Join a dynamic team to deliver clinical education and support for diagnostic cardiology solutions, enhancing customer experience and driving successful outcomes through expert training and collaborati...
Yesterday
$80K - $95K *
Empower our analyst relations program by managing evaluations, timelines, and coordination. Collaborate with stakeholders to ensure accurate, timely engagement and support market insights for strategi...
Reposted 4 weeks ago
Director, Clinical Pharmacology
$189K - $246K *
Lead clinical pharmacology strategies, integrating PK/PD assessments across development phases. Collaborate with cross-functional teams to guide decision-making and regulatory submissions, ensuring al...
Today
Medical Director, Gastroenterology
$210K - $250K *
Unlock potential by leveraging your GI expertise to enhance product development, strengthen customer relationships, and drive growth in a dynamic SaaS environment. Collaborate across teams to deliver...
1 week ago
$100K - $120K *
Support clinical studies by assisting teams with tasks like medical monitoring and protocol management. Collaborate across functions and engage with stakeholders to ensure successful trial outcomes wh...
4 weeks ago
$87K - $151K *
Unlock potential by providing expert remote clinical applications support for advanced molecular imaging. Leverage your clinical knowledge and customer service skills to enhance productivity and deliv...
2 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.