Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$80K - $95K *
Drive the Arbitration Team's success by leading initiatives that enhance performance, streamline processes, and foster client relationships. Oversee daily operations and ensure exceptional service del...
3 weeks ago
Staff Technical Program Manager
$120K - $145K *
Drive execution of complex technical initiatives, translating business vision into actionable programs. Collaborate with cross-functional teams to ensure alignment with company objectives and measurab...
1 week ago
Regional Manager - Urology (Midwest)
$143K - $291K *
Join a team that's dedicated to empowering healthcare professionals through innovative medical devices. Lead a high-performing sales organization, drive revenue growth, and enhance patient care with c...
1 week ago
$107K - $145K *
Drive growth by identifying and securing new business opportunities in risk management and medical education. Collaborate with teams to develop proposals, manage sales pipelines, and ensure alignment...
Reposted yesterday
$229K - $310K *
Drive project management and business development to enhance operational efficiency in life sciences R&D, while leading diverse teams and ensuring profitability through strategic customer engagement a...
Reposted 4 days ago
Director, Biologics Process Development
$223K - $233K *
Deliver strategic leadership in biologics process development, overseeing outsourced manufacturing and ensuring alignment with corporate goals while driving technical excellence in late-stage developm...
1 month ago
Senior Oncology Account Manager, Harrisburg
$150K - $230K *
Transform healthcare by building strong relationships with key oncology stakeholders. Drive product promotion and exceed performance goals while ensuring patient access to innovative therapies in a dy...
1 week ago
Solutions Architect, Digital Platforms
$188K - $282K *
Drive the architecture for customer data integration across digital platforms, ensuring secure ingestion and transformation. Collaborate with cross-functional teams to create scalable solutions that e...
Yesterday
Manager, Provider Operations - Provider Data
$73K - $115K *
Help us drive operational excellence in provider data management, ensuring accuracy and efficiency throughout the lifecycle. Collaborate with teams to enhance processes, leverage insights, and impleme...
3 days ago
$160K - $175K *
Empower client success by leading account health, driving growth, and managing budgets. Collaborate with cross-functional teams to deliver integrated campaigns while mentoring your account team and en...
Reposted 6 days ago
$163K - $245K *
Shape security architecture by designing robust frameworks across various tech domains. Collaborate with cross-functional teams to ensure comprehensive cybersecurity solutions aligned with business go...
Reposted 3 weeks ago
$72K - $116K *
Engage in financial analysis and reporting, developing forecasts and insights. Collaborate across departments to enhance business outcomes and present findings to management, driving strategic decisio...
Reposted 1 week ago
Senior Oncology Account Manager, Charlotte
$150K - $230K *
Empower your career by driving oncology product success through strategic relationships and innovative solutions. Lead market engagement, exceed performance goals, and enhance patient access while col...
1 week ago
Senior Director/VP - Translational Medicine & Pharmacology
$210K - $250K *
Drive the translational strategy for immunology therapies, focusing on biomarker development and clinical pharmacology. Collaborate cross-functionally to advance pipeline assets and support regulatory...
1 week ago
$90K - $95K *
Drive the successful adoption of advanced hearing solutions by providing expert clinical support and education to healthcare professionals. Collaborate closely with cross-functional teams to enhance p...
4 weeks ago
Vice President, Revenue Integrity - DRG & DRGV (REMOTE)
$150K - $180K *
Drive your career with a leadership role focused on Revenue Integrity, overseeing strategic direction, performance metrics, and team development to enhance operational efficiency and client satisfacti...
2 days ago
Enterprise Account Executive (General Contractor)
$110K - $130K *
Drive transformative change in the construction industry by leveraging your General Contractor expertise to lead complex sales cycles and deliver innovative SaaS solutions that address customer pain p...
4 weeks ago
Registered Nurse (RN) | Womens and Childrens Unit
$67K - $100K *
Champion patient care by delivering comprehensive nursing support through assessments, interventions, and education to enhance health outcomes and promote well-being across diverse settings...
Reposted 3 weeks ago
$170K - $195K *
Engage in strategic account acquisition for our Legal Technologies sector, focusing on sourcing, qualifying, and closing new enterprise accounts. Drive revenue growth through complex sales cycles whil...
2 weeks ago
AI Strategy Associate Director - State Health
$122K - $203K *
Champion AI innovation by leading strategy and implementation for Medicaid programs, enhancing operational excellence, and driving sustainable value across State Health agencies and their analytics ca...
Reposted yesterday
$108K - $130K *
Lead the charge in enhancing site-of-care strategies by assessing, planning, and executing programs that optimize product administration across diverse healthcare settings, ensuring effective collabor...
Today
Regional Sales Director - Oklahoma City
$180K - $215K *
Elevate regional sales performance by leading a high-impact team, executing strategic launches, and fostering key customer relationships in a dynamic, fast-paced environment. Drive accountability and...
1 week ago
Senior Quality Operations Specialist, CAP & Monitoring
$74K - $98K *
Elevate quality operations by leading corrective action plans (CAPs) for regulatory compliance. Collaborate with cross-functional teams to drive accountability, resolve barriers, and ensure sustained...
3 weeks ago
Manager, Training & Workflow Optimization
$79K - $94K *
Lead the development and execution of training programs while optimizing workflows to enhance provider experiences. Collaborate with stakeholders to ensure effective training delivery and continuous i...
1 week ago
Senior Analyst of Transformation
$95K - $115K *
Join a team that's driving transformative change through strategic analysis and execution. This high-visibility role collaborates with leadership to ensure progress on critical initiatives and enhance...
Reposted 2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.