Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Anesthesiologist Jobs in South Dakota

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$141K - $234K *

Transform healthcare analytics by leveraging advanced statistics and machine learning to uncover insights from complex datasets. Collaborate with experts to innovate and develop data-driven solutions...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$300K - $350K *

Transform your career by leading a national body imaging service line, optimizing workflows, and enhancing clinical quality standards while mentoring a dedicated team of radiologists across multiple l...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$240K - $269K *

Advance your career by leading national account strategies in oncology, fostering relationships with health plans and PBMs. Drive coverage, reimbursement, and adoption initiatives while collaborating...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$64K - $96K *

Join a team that's dedicated to delivering exceptional nursing care by developing personalized care plans, providing comprehensive support, and collaborating with healthcare professionals to enhance p...

Today

  •   Less than 5 years exp.  •   Healthcare

$92K - $110K *

Deliver strategic leadership and operational oversight to enhance decision-making processes within the Veterans Health Administration's EHRM, ensuring effective collaboration and communication across...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$250K - $350K *

Transform high-ticket sales by conducting inbound evaluation calls with pre-qualified prospects. Engage in deep discovery conversations, present exclusive membership, and enroll elite real estate prof...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$73K - $91K *

Lead compassionate patient care as a Registered Nurse, utilizing clinical expertise to enhance health outcomes. Collaborate with interdisciplinary teams in a dynamic environment, ensuring quality and...

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$195K - $325K *

Join a team that's shaping the future of AI in healthcare by leading multi-year strategies, resolving complex technical challenges, and influencing executive decisions across the organization to ensur...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Transform healthcare through innovative AI deployments. As a key technical expert, you'll develop and implement cutting-edge systems that enhance clinical workflows and optimize patient interactions...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$198K - $268K *

Lead the global GMP/GDP audit organization, enhancing predictive compliance intelligence while mitigating risks through advanced analytics and effective audit strategies...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$78K - $156K *

Join a team that's dedicated to enhancing business systems through design, configuration, and support. As a Senior Application Analyst, you'll lead improvements, mentor junior analysts, and ensure sea...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Join a team that's transforming the construction industry by leading complex sales cycles with major Specialty Contractors. Leverage your project management expertise to drive innovative SaaS solution...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $150K *

Drive total rewards strategy by managing compensation, benefits, and equity programs. Lead initiatives to ensure competitive, fair, and transparent offerings while supporting a growing workforce throu...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$300K *

Elevate healthcare delivery by leading a dedicated team in clinical evaluations, ensuring best practices while providing client-facing support and expertise in medical claims, regulations, and emergin...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$150K - $170K *

Join a team that's transforming drug development through data science. Leverage your expertise to build predictive models and analytics, driving process improvements and technology transfer in a colla...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Unlock potential by leading product strategy for patient recruitment, enhancing engagement and operational efficiency. Collaborate with cross-functional teams to drive measurable outcomes and improve...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$85K - $97K *

Shape the future of healthcare by conducting clinical case reviews and enhancing product quality for an AI-driven clinical platform. Collaborate with care teams to ensure accurate alert functionality...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $130K *

Empower your career by leading quality assurance efforts for critical healthcare systems. Collaborate with teams to enhance user experiences for Veterans, ensuring high-quality service delivery throug...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$67K - $100K *

Lead patient care by developing nursing diagnoses and interventions, providing comprehensive support to patients and families, and collaborating with healthcare teams to ensure optimal health outcomes...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $150K *

Join a team that's dedicated to transforming the mental health landscape, providing comprehensive telehealth care for individuals with eating disorders while collaborating closely with a multidiscipli...

United StatesRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Join a team that's redefining software engineering by integrating AI tools to accelerate the development process. Transform requirements into reliable solutions while ensuring quality, security, and m...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Healthcare

$122K - $171K *

Unlock potential by driving data-driven insights for Customer Success. Collaborate across teams to enhance customer journeys, optimize growth strategies, and shape analytics foundations that support A...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$173K - $245K *

Unlock insights through data analytics and experimentation to enhance credit risk management. Collaborate with cross-functional teams to optimize policies, monitor performance, and drive strategic gro...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$195K - $217K *

Drive client success by leading strategic initiatives and fostering strong relationships in healthcare technology. Leverage deep domain expertise to enhance outcomes and ensure effective use of soluti...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$70K - $100K *

Drive your career forward by managing key partnerships and delivering measurable results. This role blends strategic relationship management with consultative selling, ensuring partner success and gro...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.