Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
RCM Implementation Consultant - EHR/SaaS/Healthcare IT/PT
$80K - $95K *
Manage the implementation process for clients in Revenue Cycle Management, ensuring efficient setup and optimization of billing workflows. Serve as the primary expert, guiding healthcare organizations...
1 week ago
Clinical Sales Representative - Atlanta
$100K - $120K *
Provide strategic leadership in territory management, driving revenue growth and innovation within complex healthcare environments. Cultivate executive relationships and promote clinical adoption to e...
Reposted 3 weeks ago
$110K - $130K *
Lead the quality assurance efforts for commissioning, qualification, and validation across multiple manufacturing sites, ensuring compliance with cGMP standards while collaborating with cross-function...
2 weeks ago
Senior Director, Early Oncology
$230K - $345K *
Transform clinical trial management by leading early-phase oncology programs. Drive strategic vision, operational excellence, and cross-functional collaboration to ensure timely, budget-compliant exec...
Today
Regional Sales Director - Northwest
$180K - $215K *
Unlock regional growth by leading a high-performing sales team, executing launch strategies, and fostering key customer relationships in a dynamic, fast-paced environment. Drive performance and ensure...
1 week ago
Sr Manager, Global Regulatory Affairs (AI/ML)
$150K - $180K *
Unlock potential by guiding global regulatory strategies for innovative AI/ML healthcare solutions. Collaborate cross-functionally to navigate complex regulations while balancing innovation and patien...
Reposted 4 weeks ago
$100K - $120K *
Join us to oversee pharmacy services, ensuring quality care through effective planning, execution, and evaluation. Collaborate with healthcare teams to enhance patient outcomes while supervising staff...
1 week ago
Director- Allied Health Programs
$80K - $90K *
Elevate healthcare education by leading the development of innovative allied health programs. Drive growth and improvement through strategic partnerships, curriculum design, and compliance, ensuring l...
3 weeks ago
Senior Director / Director , Breast Oncology Lifecycle Management
$186K - $233K *
Pioneer innovative strategies in breast oncology, driving commercial success through collaboration and data-driven insights. Lead cross-functional teams to enhance product adoption and optimize market...
3 weeks ago
Manager, Performance Marketing
$105K - $115K *
Join a team that's focused on diversifying paid media channels and optimizing conversion strategies. You'll lead initiatives across affiliate, programmatic, and social platforms to enhance member acqu...
1 week ago
Senior Manager, Integrated Intelligence
$85K - $105K *
Shape impactful insights through analytics, driving data-informed decisions for healthcare clients. Collaborate with cross-functional teams to enhance marketing performance and audience understanding...
Reposted 1 week ago
$66K - $106K *
Join a team that's dedicated to conducting thorough medical reviews and applying clinical judgment to ensure compliance and prevent fraud in healthcare claims. Collaborate with professionals to suppor...
1 week ago
Senior Financial Analyst (Product & Delivery)
$100K - $120K *
Drive financial excellence by integrating and analyzing revenue and expense forecasts, ensuring alignment across functions. Collaborate with FP&A teams to deliver actionable insights and support strat...
3 weeks ago
Senior Oncology Account Manager, Houston
$150K - $230K *
Manage strategic oncology product promotion and build relationships with key stakeholders. Drive performance goals, analyze market data, and ensure patient access to therapies while embodying corporat...
1 week ago
Manager, Training & Workflow Optimization
$79K - $94K *
Optimize training and workflow processes by leading program development, mentoring trainers, and collaborating with stakeholders to enhance provider experiences and operational efficiency across Care...
Today
Senior Sourcer, Quantitative Research
$125K - $150K *
Develop and execute effective sourcing strategies to attract top technical talent in Research and Data Science, ensuring a positive candidate experience while driving organizational growth and high hi...
Reposted 4 weeks ago
Senior Oncology Account Manager, Cleveland
$150K - $230K *
Drive impactful oncology product promotion by building strong relationships with key stakeholders. Leverage clinical expertise and market insights to exceed performance goals while ensuring patient ac...
1 week ago
Virtual Director of Enrollment
$95K - $105K *
Transform enrollment strategies by building relationships and guiding families through the educational journey. Drive growth, manage pipelines, and leverage insights to enhance performance in a dynami...
2 days ago
$69K - $104K *
Unlock your potential as a coding auditor, ensuring accurate documentation and coding while promoting compliance and reimbursement optimization. Collaborate with coders and specialists to enhance proc...
1 month ago
$100K - $120K *
Unlock potential by delivering comprehensive health assessments in patients' homes. This role requires extensive travel within a region, ensuring quality care and education while collaborating with he...
2 weeks ago
$100K - $120K *
Drive comprehensive health assessments by traveling to patients' homes, ensuring accurate documentation and patient education. Collaborate with healthcare teams to enhance care continuity while managi...
2 weeks ago
Manager of Provider Network and Pricing Strategy
$95K - $115K *
Drive provider network excellence by managing data integrity, overseeing contract configurations, and leading cross-functional teams to enhance operational efficiency and compliance in a dynamic TPA e...
1 week ago
Manager, Market Access and Reimbursement - North Central
$136K - $170K *
Partner with us to enhance patient access by leading market access strategies, educating teams, and collaborating across departments to ensure effective reimbursement for our innovative medical techno...
4 weeks ago
$80K - $95K *
Transform credentialing operations by leading a dedicated team to ensure compliance, enhance efficiency, and support provider network growth through strategic oversight and process improvement initiat...
2 weeks ago
Senior Statistical Programmer Analyst - T
$136K - $239K *
Unlock your potential by leading statistical programming efforts in clinical trials. Collaborate with cross-functional teams to analyze and report clinical data, ensuring compliance with industry stan...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.