Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Director, Strategic Growth & Operations
$150K - $200K *
Empower strategic growth and operations by integrating cross-functional teams, aligning priorities, and driving initiatives to enhance study delivery and operational excellence in a dynamic environmen...
Today
Associate Director, Virtual Health
$115K - $125K *
Drive the development and management of virtual health services, enhancing operational excellence and patient experience while scaling innovative care models across the organization. Lead strategic in...
Yesterday
Associate Director, Medical Strategic Operations (Field)
$175K - $219K *
Help us elevate Field Medical operations by optimizing processes, enhancing communication, and driving strategic initiatives to ensure effective engagement and alignment across teams in a dynamic heal...
Today
Clinical Scientist - Oncology - Home-based anywhere in the US - FSP
$110K - $130K *
Elevate your career by supporting clinical studies through scientific expertise, operational delivery, and compliance. Collaborate with cross-functional teams and stakeholders to ensure successful tri...
3 weeks ago
Associate Director, Thought Leader Liaison, Oncology - Central
$157K - $256K *
Champion strategic engagements with oncology thought leaders to enhance insights and drive initiatives for our Solid Tumor portfolio, focusing on collaboration across teams and executing regional stra...
1 week ago
Surgical Sales Executive- Chicago/Minneapolis
$110K - $130K *
Drive growth by promoting innovative regenerative medicine solutions. Leverage your expertise in vascular surgery sales and establish strong customer relationships to achieve targets and make a meanin...
Reposted 5 days ago
Senior Incident Response Analyst
$115K - $130K *
Partner with us to drive Major Incident Management, ensuring swift resolution and effective communication across teams. Leverage your expertise to enhance service restoration and support our hosted cu...
2 weeks ago
Senior Clinical Operations Manager, Canada/USA, remote
$110K - $130K *
Transform clinical operations by leading a dynamic team, ensuring high-quality trial management, and driving innovation through technology and AI solutions. Your strategic oversight will enhance perfo...
1 week ago
$150K - $180K *
Join a team that's redefining scientific data management in drug discovery. Lead the scientific data team, bridging scientists and engineers to ensure data integrity, quality, and innovative solutions...
3 weeks ago
$150K - $200K *
Lead the charge in delivering complex federal digital services programs, ensuring strategic direction, operational excellence, and strong customer relationships across multidisciplinary teams while ma...
Reposted yesterday
Senior Oncology Account Manager, Nashville
$150K - $230K *
Champion the promotion of oncology products, building strong relationships with healthcare professionals to enhance patient access and drive brand success in a competitive market. Leverage clinical ex...
1 week ago
Hospital Coding Quality Integrity Analyst - Inpatient
$73K - $110K *
Drive coding quality and compliance by analyzing data, supporting audits, and enhancing documentation practices. Collaborate with teams to ensure accurate coding and adherence to regulatory standards...
1 week ago
Associate Director, Clinical Supply Chain (Remote)
$150K - $185K *
Architect comprehensive clinical supply strategies for global trials. Collaborate across functional teams to secure timely, compliant drug supply while managing risks and inventory effectively, ensuri...
Reposted 3 days ago
$76K - $96K *
Empower patient care by joining our dedicated nursing team, where you'll provide compassionate, quality care in a fast-paced environment. Collaborate with healthcare professionals to enhance patient o...
6 days ago
$90K - $110K *
Analyze clinical documentation and risk adjustment for healthcare providers, ensuring accurate representation of patient acuity. Collaborate with physicians to identify documentation opportunities and...
4 weeks ago
$131K - $151K *
Unlock your potential as a Nurse Practitioner, providing essential primary care to underserved communities. Collaborate with a dedicated team to enhance patient health and deliver quality services in...
4 weeks ago
$210K - $225K *
Pioneer innovative research strategies to enhance clinical outcomes and drive impactful insights through collaboration across teams, while establishing a robust research infrastructure and publication...
1 month ago
$110K - $210K *
Advance your career by designing innovative Anaplan solutions that address client needs while leading Agile projects and training teams. Shape the technical vision and enhance processes for impactful...
Reposted yesterday
Manager, Reputation and Consumer Insights
$120K - $150K *
Drive reputation management and consumer insights initiatives, enhancing brand trust and informing strategic decisions. Collaborate across teams to analyze data, identify trends, and improve consumer...
2 weeks ago
$83K - $108K *
Join a team that's dedicated to nurturing key accounts and driving customer success. You'll cultivate long-term relationships, collaborate across departments, and ensure optimal performance for our hi...
Reposted 5 days ago
$80K - $95K *
Drive analytical excellence by auditing freight contracts and invoices, ensuring compliance and accuracy. Collaborate with teams to enhance audit processes and mentor junior analysts, contributing to...
1 week ago
$110K - $130K *
Lead the creative vision and execution of impactful design assets, enhancing brand identity and streamlining production processes using AI tools. Collaborate across teams to deliver high-quality marke...
3 weeks ago
$80K - $145K *
Join a team that's advancing data analytics for VA modernization initiatives. Utilize SQL and Python to drive AI-enabled insights, enhance operational workflows, and support decision-making through ri...
2 days ago
Senior Budget Administrator - Clinical Trials
$100K - $161K *
Advance your career by coordinating clinical trial budgets and coverage analyses. Collaborate with stakeholders to ensure compliance and cost efficiency while mentoring junior staff and enhancing admi...
6 days ago
Director/Sr. Director Clinical Pharmacology
$262K - $284K *
Optimize pediatric drug development strategies as a clinical pharmacology leader, overseeing pharmacometric analyses and regulatory submissions, while translating complex data into actionable decision...
Reposted 3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.