Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Anesthesiologist Jobs in South Dakota

Sort By: Relevance

$150K - $200K *

Empower strategic growth and operations by integrating cross-functional teams, aligning priorities, and driving initiatives to enhance study delivery and operational excellence in a dynamic environmen...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$115K - $125K *

Drive the development and management of virtual health services, enhancing operational excellence and patient experience while scaling innovative care models across the organization. Lead strategic in...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$175K - $219K *

Help us elevate Field Medical operations by optimizing processes, enhancing communication, and driving strategic initiatives to ensure effective engagement and alignment across teams in a dynamic heal...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Elevate your career by supporting clinical studies through scientific expertise, operational delivery, and compliance. Collaborate with cross-functional teams and stakeholders to ensure successful tri...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$157K - $256K *

Champion strategic engagements with oncology thought leaders to enhance insights and drive initiatives for our Solid Tumor portfolio, focusing on collaboration across teams and executing regional stra...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Drive growth by promoting innovative regenerative medicine solutions. Leverage your expertise in vascular surgery sales and establish strong customer relationships to achieve targets and make a meanin...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$115K - $130K *

Partner with us to drive Major Incident Management, ensuring swift resolution and effective communication across teams. Leverage your expertise to enhance service restoration and support our hosted cu...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Transform clinical operations by leading a dynamic team, ensuring high-quality trial management, and driving innovation through technology and AI solutions. Your strategic oversight will enhance perfo...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Join a team that's redefining scientific data management in drug discovery. Lead the scientific data team, bridging scientists and engineers to ensure data integrity, quality, and innovative solutions...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $200K *

Lead the charge in delivering complex federal digital services programs, ensuring strategic direction, operational excellence, and strong customer relationships across multidisciplinary teams while ma...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $230K *

Champion the promotion of oncology products, building strong relationships with healthcare professionals to enhance patient access and drive brand success in a competitive market. Leverage clinical ex...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$73K - $110K *

Drive coding quality and compliance by analyzing data, supporting audits, and enhancing documentation practices. Collaborate with teams to ensure accurate coding and adherence to regulatory standards...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $185K *

Architect comprehensive clinical supply strategies for global trials. Collaborate across functional teams to secure timely, compliant drug supply while managing risks and inventory effectively, ensuri...

United StatesRemote

Reposted 3 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$76K - $96K *

Empower patient care by joining our dedicated nursing team, where you'll provide compassionate, quality care in a fast-paced environment. Collaborate with healthcare professionals to enhance patient o...

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $110K *

Analyze clinical documentation and risk adjustment for healthcare providers, ensuring accurate representation of patient acuity. Collaborate with physicians to identify documentation opportunities and...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$131K - $151K *

Unlock your potential as a Nurse Practitioner, providing essential primary care to underserved communities. Collaborate with a dedicated team to enhance patient health and deliver quality services in...

4 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$210K - $225K *

Pioneer innovative research strategies to enhance clinical outcomes and drive impactful insights through collaboration across teams, while establishing a robust research infrastructure and publication...

United StatesRemote

1 month ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $210K *

Advance your career by designing innovative Anaplan solutions that address client needs while leading Agile projects and training teams. Shape the technical vision and enhance processes for impactful...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $150K *

Drive reputation management and consumer insights initiatives, enhancing brand trust and informing strategic decisions. Collaborate across teams to analyze data, identify trends, and improve consumer...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$83K - $108K *

Join a team that's dedicated to nurturing key accounts and driving customer success. You'll cultivate long-term relationships, collaborate across departments, and ensure optimal performance for our hi...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Drive analytical excellence by auditing freight contracts and invoices, ensuring compliance and accuracy. Collaborate with teams to enhance audit processes and mentor junior analysts, contributing to...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$110K - $130K *

Lead the creative vision and execution of impactful design assets, enhancing brand identity and streamlining production processes using AI tools. Collaborate across teams to deliver high-quality marke...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $145K *

Join a team that's advancing data analytics for VA modernization initiatives. Utilize SQL and Python to drive AI-enabled insights, enhance operational workflows, and support decision-making through ri...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Business Services

$100K - $161K *

Advance your career by coordinating clinical trial budgets and coverage analyses. Collaborate with stakeholders to ensure compliance and cost efficiency while mentoring junior staff and enhancing admi...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$262K - $284K *

Optimize pediatric drug development strategies as a clinical pharmacology leader, overseeing pharmacometric analyses and regulatory submissions, while translating complex data into actionable decision...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.