Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$85K - $125K *
Contribute to acquiring and managing data partnerships, collaborating with product teams to prioritize and improve dataset quality, while leveraging AI to enhance data processes and achieve business o...
Reposted 3 weeks ago
Diagnosis-Related Group (DRG) Auditor III
$73K - $98K *
Join a team that's dedicated to excellence in DRG auditing. Leverage your expertise in MS-DRG and APR-DRG coding to ensure accuracy and compliance while working remotely. Enjoy a collaborative environ...
Today
Senior Manager, Physical Therapy
$110K - $130K *
Lead the charge in optimizing physical therapy operations, enhancing care quality and access through strategic resource allocation and team development. Collaborate across clinical functions to drive...
3 days ago
Interventional Radiology Technologist
$73K - $111K *
Empower patient care by performing specialized interventional radiology procedures. Collaborate with medical teams to ensure optimal outcomes while maintaining high standards of safety and quality in...
Yesterday
Registered Nurse (RN) | Women's Center
$67K - $100K *
Elevate patient care by delivering comprehensive nursing services, collaborating with healthcare teams, and providing emotional support to patients and families while ensuring adherence to safety and...
2 days ago
Project Manager - Medical Communications
$80K - $95K *
Advance your career by managing diverse medical communications projects, ensuring timely delivery and client satisfaction while leading multidisciplinary teams and maintaining strong relationships wit...
3 weeks ago
Associate Director, Study Operations Manager - Nonclinical Toxicology
$129K - $231K *
Elevate nonclinical toxicology operations by managing study execution, ensuring compliance, and fostering collaboration across teams to advance innovative therapies for sleep-wake disorders. Drive acc...
2 days ago
$110K - $130K *
Drive impactful solutions as you lead integration efforts, enhancing user experiences through collaboration and innovation while managing multiple complex projects and mentoring junior engineers...
4 weeks ago
Project Manager 2, Patient Monitoring (Northeast and Mid-Atlantic Region)
$85K - $125K *
Collaborate with cross-functional teams to lead large-scale healthcare projects, ensuring timely installation and customer satisfaction. Manage project scope, timelines, and resources while communicat...
Reposted yesterday
Remote Breast Radiologist - RP Eagle
$250K - $300K *
Partner with us to provide expert breast imaging interpretation in a fully remote setting. Enjoy flexible scheduling and a supportive team environment while contributing to exceptional patient care ac...
1 week ago
Account Executive, Enterprise Suite - Financial Services
$124K - $171K *
Accelerate sales growth by managing and qualifying strategic Enterprise Intelligence opportunities. Collaborate with cross-functional teams, ensuring comprehensive engagement and communication to opti...
Reposted 3 days ago
$80K - $95K *
Drive revenue cycle optimization by enhancing Epic Professional Billing workflows, collaborating with stakeholders, and resolving claims challenges to improve overall operational efficiency and ensure...
4 weeks ago
$68K - $126K *
Transform medical billing operations by leading a team to optimize systems, enhance service delivery, and drive continuous improvement through technology and structured practices, ensuring accountabil...
3 days ago
ED, Advance Analytics and Precision Health
$225K - $418K *
Champion advanced analytics to enhance patient outcomes through data-driven insights. Lead a team in analyzing healthcare data, fostering strategic partnerships, and communicating complex findings to...
2 days ago
Nationwide- Clinical Psychologist (remote)
$80K - $95K *
Support patient evaluations by conducting psychological assessments and collaborating with a clinical team to enhance diagnostic outcomes and treatment plans. Leverage expertise in standardized testin...
4 weeks ago
Senior Architect, Professional Services
$170K - $220K *
Shape the future of customer solutions by leading implementations and driving adoption of innovative technologies. Collaborate with teams to deliver tailored architectural designs that meet strategic...
1 week ago
Physical Therapist - Children's | Full-Time
$73K - $108K *
Manage and deliver comprehensive physical therapy programs for diverse clients, conducting evaluations and interventions to enhance mobility, relieve pain, and improve strength. Collaborate with healt...
4 weeks ago
$95K - $115K *
Analyze financial performance and operational metrics to support strategic growth initiatives. Collaborate with cross-functional teams to enhance reporting accuracy and drive insights for decision-mak...
Reposted 2 days ago
Senior Compliance Assurance Advisor
$110K - $130K *
Transform your career by leading compliance assurance initiatives that enhance the reliability of the North American electric grid. Collaborate with industry stakeholders to develop and implement risk...
2 weeks ago
$144K - $160K *
Champion operational excellence by leading teams to enhance efficiency and care delivery. Drive AI integration, manage P&L, and collaborate cross-functionally to support growth and sustainability in h...
1 week ago
Senior Site Identification Analyst (Contractor)
$100K - $120K *
Join a team that's dedicated to enhancing clinical operations through strategic site identification and management. Leverage your expertise to build relationships, track project timelines, and contrib...
2 weeks ago
$120K - $145K *
Join a team that's dedicated to safeguarding sensitive health information while enhancing security across cloud and application environments. As a Senior Security Engineer, you'll design and implement...
Today
$80K - $95K *
Empower growth by developing strategic relationships with biotech and pharma clients. Drive market awareness and increase RFPs through collaboration with the business development team, leveraging your...
1 week ago
$136K - $187K *
Join a team that's dedicated to empowering patients with generalized Myasthenia Gravis through education and support. As a key point of contact, you'll coordinate care, provide resources, and ensure c...
1 week ago
Director, Strategic Growth & Operations
$150K - $200K *
Empower strategic growth and operations by integrating cross-functional teams, aligning priorities, and driving initiatives to enhance study delivery and operational excellence in a dynamic environmen...
Today
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.