Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Anesthesiologist Jobs in South Dakota

Sort By: Relevance

$85K - $125K *

Contribute to acquiring and managing data partnerships, collaborating with product teams to prioritize and improve dataset quality, while leveraging AI to enhance data processes and achieve business o...

RemoteRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$73K - $98K *

Join a team that's dedicated to excellence in DRG auditing. Leverage your expertise in MS-DRG and APR-DRG coding to ensure accuracy and compliance while working remotely. Enjoy a collaborative environ...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Business Services

$110K - $130K *

Lead the charge in optimizing physical therapy operations, enhancing care quality and access through strategic resource allocation and team development. Collaborate across clinical functions to drive...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$73K - $111K *

Empower patient care by performing specialized interventional radiology procedures. Collaborate with medical teams to ensure optimal outcomes while maintaining high standards of safety and quality in...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$67K - $100K *

Elevate patient care by delivering comprehensive nursing services, collaborating with healthcare teams, and providing emotional support to patients and families while ensuring adherence to safety and...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Advance your career by managing diverse medical communications projects, ensuring timely delivery and client satisfaction while leading multidisciplinary teams and maintaining strong relationships wit...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$129K - $231K *

Elevate nonclinical toxicology operations by managing study execution, ensuring compliance, and fostering collaboration across teams to advance innovative therapies for sleep-wake disorders. Drive acc...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Drive impactful solutions as you lead integration efforts, enhancing user experiences through collaboration and innovation while managing multiple complex projects and mentoring junior engineers...

RemoteRemote

4 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$85K - $125K *

Collaborate with cross-functional teams to lead large-scale healthcare projects, ensuring timely installation and customer satisfaction. Manage project scope, timelines, and resources while communicat...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

$250K - $300K *

Partner with us to provide expert breast imaging interpretation in a fully remote setting. Enjoy flexible scheduling and a supportive team environment while contributing to exceptional patient care ac...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$124K - $171K *

Accelerate sales growth by managing and qualifying strategic Enterprise Intelligence opportunities. Collaborate with cross-functional teams, ensuring comprehensive engagement and communication to opti...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$80K - $95K *

Drive revenue cycle optimization by enhancing Epic Professional Billing workflows, collaborating with stakeholders, and resolving claims challenges to improve overall operational efficiency and ensure...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$68K - $126K *

Transform medical billing operations by leading a team to optimize systems, enhance service delivery, and drive continuous improvement through technology and structured practices, ensuring accountabil...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$225K - $418K *

Champion advanced analytics to enhance patient outcomes through data-driven insights. Lead a team in analyzing healthcare data, fostering strategic partnerships, and communicating complex findings to...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Support patient evaluations by conducting psychological assessments and collaborating with a clinical team to enhance diagnostic outcomes and treatment plans. Leverage expertise in standardized testin...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$170K - $220K *

Shape the future of customer solutions by leading implementations and driving adoption of innovative technologies. Collaborate with teams to deliver tailored architectural designs that meet strategic...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$73K - $108K *

Manage and deliver comprehensive physical therapy programs for diverse clients, conducting evaluations and interventions to enhance mobility, relieve pain, and improve strength. Collaborate with healt...

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Analyze financial performance and operational metrics to support strategic growth initiatives. Collaborate with cross-functional teams to enhance reporting accuracy and drive insights for decision-mak...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Transform your career by leading compliance assurance initiatives that enhance the reliability of the North American electric grid. Collaborate with industry stakeholders to develop and implement risk...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$144K - $160K *

Champion operational excellence by leading teams to enhance efficiency and care delivery. Drive AI integration, manage P&L, and collaborate cross-functionally to support growth and sustainability in h...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Join a team that's dedicated to enhancing clinical operations through strategic site identification and management. Leverage your expertise to build relationships, track project timelines, and contrib...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Join a team that's dedicated to safeguarding sensitive health information while enhancing security across cloud and application environments. As a Senior Security Engineer, you'll design and implement...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Empower growth by developing strategic relationships with biotech and pharma clients. Drive market awareness and increase RFPs through collaboration with the business development team, leveraging your...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$136K - $187K *

Join a team that's dedicated to empowering patients with generalized Myasthenia Gravis through education and support. As a key point of contact, you'll coordinate care, provide resources, and ensure c...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $200K *

Empower strategic growth and operations by integrating cross-functional teams, aligning priorities, and driving initiatives to enhance study delivery and operational excellence in a dynamic environmen...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.