Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Clinical Trial Manager (CTM)
$168K - $188K *
Oversee and manage clinical trials from protocol development to final report, ensuring compliance with GCP and regulatory standards. Collaborate with cross-functional teams to enhance research efficie...
Reposted 4 weeks ago
Director, Centralized Case Management
$110K - $130K *
Elevate your career by providing strategic leadership for a national remote case management team, ensuring service excellence, operational consistency, and client satisfaction while collaborating with...
3 weeks ago
Senior Director, Head of R&D Governance and Portfolio Management
$228K - $342K *
Advance the future of R&D governance and portfolio management by leading strategic decision-making processes, optimizing operational efficiency, and ensuring seamless progression of therapeutic assets...
Yesterday
$110K - $130K *
Elevate market presence by driving adoption of innovative cardiac imaging solutions. Collaborate with healthcare professionals to enhance patient care, achieve sales targets, and optimize business str...
3 weeks ago
$80K - $95K *
Join a team that's dedicated to optimizing privacy management processes and compliance technology. This role supports platform administration, user engagement, and operational improvements, ensuring e...
2 weeks ago
Principal, Data Governance Platforms
$149K - $224K *
Shape the future of data governance by leading the design and implementation of enterprise platforms that ensure data integrity, quality, and compliance across the organization, while collaborating wi...
2 weeks ago
Associate Director - Clinical Operations - Healthcare
$155K - $259K *
Transform healthcare performance by leading integrated optimization programs that enhance clinical, operational, and financial outcomes for hospitals and health systems. Drive measurable results throu...
3 days ago
Senior Director, Alliance Management
$242K - $290K *
Empower strategic partnerships by managing alliances, driving collaboration, and ensuring alignment with organizational goals. Leverage your expertise to foster trust and deliver impactful outcomes in...
3 days ago
Managing Director, Construction Disputes & Advisory
$160K - $200K *
Unlock potential by leading high-performing teams in construction disputes and advisory. Drive client relationships, innovate solutions, and ensure quality execution while fostering growth and collabo...
3 weeks ago
$136K - $187K *
Unlock potential by serving as a vital resource for patients and caregivers, providing education and support for managing generalized Myasthenia Gravis while coordinating treatment and navigating insu...
1 week ago
Manager, Coding Hospital & Physician Services
$80K - $95K *
Elevate your career by managing coding operations, ensuring accuracy and compliance across healthcare settings. Lead educational initiatives for staff, optimize workflows, and drive improvements in co...
2 weeks ago
Executive Director, Clinical Supply Consulting & Intelligence
$250K - $350K *
Lead the development of a clinical supply consulting practice, combining expertise in forecasting, planning, and optimization to enhance decision-making for sponsors. Drive innovation and commercial g...
2 weeks ago
$175K - $200K *
Transform global talent acquisition by leading a multi-country team, setting strategic vision, and optimizing recruitment processes to meet business growth while ensuring compliance and enhancing cand...
1 week ago
Registered Nurse (RN) | Pre-Post Operative
$67K - $100K *
Oversee comprehensive nursing care by developing tailored care plans, providing emotional support, and collaborating with healthcare teams to ensure optimal patient outcomes and safety in a dynamic cl...
6 days ago
Associate Director, Marketing, Lung Patient
$186K - $233K *
Shape impactful marketing strategies for lung cancer programs, collaborating with cross-functional teams to drive patient engagement and launch readiness. Lead initiatives that align with brand goals...
3 days ago
Manager, Regional & Field Events
$120K - $138K *
Manage regional meetings and events, ensuring seamless execution and compliance. Oversee budgets, vendor relationships, and logistics while collaborating with cross-functional teams to meet organizati...
2 weeks ago
$90K - $120K *
Transform patient care by delivering precise teleradiology interpretations across various shifts, utilizing AI tools to enhance workflow and maintain high-quality standards while collaborating with he...
2 weeks ago
RN Nurse Clinical Documentation Improvement Specialist
$114K *
Advance clinical documentation quality by conducting thorough reviews and facilitating physician interactions to enhance accuracy and compliance in medical records, ensuring optimal patient care and r...
5 days ago
$110K - $120K *
Support a national patient community by providing critical therapy coverage across multiple states, ensuring continuity of care during clinician absences. Collaborate with multidisciplinary teams to d...
2 weeks ago
DRG Quality Analyst IV - Healthcare
$85K - $110K *
Optimize clinical DRG audits by ensuring accuracy and consistency in coding. Mentor auditors, recommend process improvements, and conduct quality reviews to enhance performance and compliance in a rem...
1 week ago
$80K - $95K *
Partner with us to enhance clinical IT solutions as an Epic Analyst II, providing critical support, training, and implementation for Epic EHR systems. Collaborate with teams to optimize workflows and...
2 weeks ago
Senior Oncology Account Manager, New Haven
$150K - $230K *
Transform the oncology landscape by driving product success and building strong relationships with key stakeholders. Leverage your expertise to enhance patient access and deliver innovative solutions...
1 week ago
Sr. Manager, Analyst Relations
$165K - $190K *
Advance your career by shaping analyst relations and market perception in AI and automation. Collaborate with cross-functional teams to drive impactful evaluations and strategic narratives that enhanc...
1 week ago
Sr Director/Director, Neurology Patient Marketing
$251K - $307K *
Champion innovative patient marketing strategies that drive engagement and awareness for a first-in-class therapy in Becker muscular dystrophy, collaborating across teams to enhance patient experience...
Reposted 2 days ago
$72K - $100K *
Join our dynamic team as a Sr. Credit Analyst, owning the underwriting cycle from application review to decision-making. Leverage your analytical skills to enhance credit processes and contribute to a...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.