Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$110K - $130K *

Lead the compliance and documentation efforts, ensuring robust privacy and security practices. Collaborate across teams to create and maintain essential documentation, audits, and operational workflow...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$134K - $219K *

Lead clinical laboratory operations for precision medicine projects, ensuring timely deliverables and risk management across therapeutic areas. Collaborate with cross-functional teams to support clini...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$90K - $100K *

Join a team that's redefining accounting excellence by managing month-end closes, revenue recognition, and international audits. Leverage your CPA expertise to enhance financial integrity and drive pr...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $230K *

Unlock potential by driving oncology product success through strategic relationships and innovative solutions. Lead efforts to enhance patient access and exceed performance goals while navigating a co...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$125K - $235K *

Drive operational excellence in healthcare by leading transformative initiatives, optimizing workflows, and enhancing provider productivity. Collaborate with teams to deliver data-driven solutions tha...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$112K - $131K *

Elevate your career by leading complex financial analyses and strategic initiatives. As a senior contributor, you'll drive enhancements in reporting, support business decisions, and mentor team member...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$90K - $110K *

Drive AI transformation by mapping current processes and designing future-state models across G&A functions. Collaborate with stakeholders to identify automation opportunities and enhance operational...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$160K - $192K *

Join a dynamic team to drive commercial performance and enhance patient access through strong relationships with healthcare providers, executing strategic business plans and supporting innovative prod...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Transform energy solutions by leading diverse projects, conducting analyses, and collaborating with clients. Utilize engineering expertise to drive efficiency and sustainability in various sectors, en...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Engineer advanced protein design models and collaborate with experts to innovate in AI Drug Discovery, driving the development of candidate antibody therapeutics through deep learning and systems biol...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$75K - $105K *

Collaborate with clients to enhance their social media strategies using healthcare insights, data-driven execution, and creative content development for multi-channel success. This role demands a proa...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$104K - $174K *

Unlock potential by driving client engagement and delivering tailored solutions. Collaborate with cross-functional teams to enhance client experiences, manage complex projects, and present insights to...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$134K - $179K *

Lead the charge in bridging genomic variants with clinical insights, collaborating with scientists to automate and scale curation workflows. Drive innovation in AI/ML applications while ensuring softw...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$225K - $281K *

Lead the charge in shaping detection and response strategies, driving hands-on initiatives to enhance security architecture and incident management. Collaborate across teams to ensure robust threat de...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Join a team that's driving innovation in transplant advocacy by integrating business development, marketing, and medical expertise. Collaborate with key stakeholders to enhance KOL engagement and mark...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Champion the end-to-end management of complex healthcare programs, ensuring operational readiness and compliance. Collaborate with teams and clients to drive successful implementations while maintaini...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead complex healthcare project initiatives, ensuring successful implementation and operational readiness while maintaining high standards of governance. Foster strong partnerships with clients, manag...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Lead the nursing department to ensure exceptional care, fostering a supportive environment while guiding clinical practices and team development. Drive continuous improvement and compliance with regul...

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$100K - $120K *

Unlock potential by mentoring new providers through virtual education, ensuring a seamless onboarding experience. Leverage your clinical expertise to foster growth in both primary care and behavioral...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $114K *

Engage in leading the Nursing department, ensuring high-quality care and compliance with regulations. Collaborate with staff to foster a supportive environment, guiding clinical practices and promotin...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$272K - $340K *

Join a team that's driving CMC strategy and execution for innovative therapies. Lead cross-functional efforts in drug and device development, ensuring compliance and operational excellence from clinic...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$155K - $210K *

Shape the future of regulatory policy by leading initiatives that influence key decisions and drive alignment across teams. Collaborate with stakeholders to advocate for impactful policies that suppor...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$236K - $259K *

Join a team that advances medical knowledge and relationships in lung cancer. As a key liaison, engage with healthcare professionals, support scientific initiatives, and collaborate cross-functionally...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$242K - $282K *

Lead the oversight of contractual matters across departments, serving as a trusted advisor to internal stakeholders from pre-clinical to commercial readiness. This role emphasizes collaboration and ex...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$160K - $259K *

Lead the charge in optimizing global drug safety operations, ensuring compliance and excellence in pharmacovigilance. Drive strategic initiatives, manage vendor relationships, and enhance processes to...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.