Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$92K - $115K *

Unlock potential by leading requirements documentation for software projects. Collaborate with stakeholders and technical teams to ensure successful delivery throughout the project lifecycle, while su...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$150K - $180K *

Drive strategic initiatives and operational excellence across a global portfolio, partnering with leadership to enhance business performance and deliver measurable outcomes in oncology and rare diseas...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$160K - $192K *

Drive commercial success by engaging healthcare providers and executing territory plans. Collaborate with cross-functional teams to support product launches and enhance patient access to innovative th...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$90K - $100K *

Join our leadership team to oversee facility maintenance and reliability, ensuring operational readiness and compliance in biomanufacturing. Drive strategic planning, budget management, and contractor...

2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Join a team that's dedicated to enhancing customer success through expert guidance in Privilege Access Management. Leverage your technical skills to support enterprise clients, ensuring seamless deplo...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$140K - $170K *

Shape the future of healthcare market strategies by analyzing trends, defining growth initiatives, and collaborating cross-functionally to drive innovation in life science and medical services. Lead m...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$90K - $110K *

Transform Medicaid programs by managing initiatives, coordinating stakeholders, and driving quality improvements. Leverage your expertise to implement policies and enhance operational efficiency in a...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$150K - $230K *

Unlock potential by driving oncology product success through strategic relationships and innovative solutions. Lead market engagement, exceed performance goals, and ensure patient access while embodyi...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$78K - $156K *

Contribute to innovative cardiac rhythm management solutions by providing expert clinical support, training, and relationship building with healthcare professionals, ensuring optimal product utilizati...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$105K - $115K *

Optimize security measures by leading technical solutions to mitigate information risks. Ensure compliance with corporate policies and oversee incident response, safeguarding all computing platforms a...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$90K - $95K *

Transform engagement in legal education by managing relationships, driving program success, and supporting bar exam strategies across multiple states. Collaborate with schools and students to enhance...

RemoteRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$150K - $230K *

Empower oncology practices by driving product adoption and building relationships with key stakeholders. Lead strategic initiatives to enhance patient access and optimize territory management while ex...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$130K - $150K *

Drive growth and strategy for key telehealth categories by leveraging market insights, customer feedback, and cross-functional collaboration to enhance performance and deliver exceptional customer exp...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$206K - $413K *

Join our team to lead in Physical Medicine and Rehabilitation, providing oversight, improving utilization, and guiding medical policy. Collaborate with staff and external partners to enhance healthcar...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Lead the charge in enhancing revenue forecasting and planning, partnering with Sales and Marketing to deliver actionable financial insights that drive growth and resource allocation across diverse rev...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$210K - $250K *

Join a team that's driving strategic growth and profitability in healthcare solutions. Lead cross-functional initiatives, own P&L, and ensure client success while shaping market strategy and solution...

United StatesRemote

Reposted today

  •   11 - 15 years exp.  •   Healthcare

$136K *

Advance patient care by leveraging nursing expertise within a dynamic team. Float across various units, ensuring ethical practices and high-quality care while collaborating with multidisciplinary prof...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$185K - $215K *

Take ownership of analytical development initiatives, ensuring compliance, accuracy, and high-quality documentation for multiple projects. Collaborate closely with internal teams and external partners...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Champion the clinical supply chain for late-stage oncology trials, ensuring seamless operations and communication between sites, suppliers, and stakeholders. Drive continuous improvement and complianc...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$280K - $340K *

Transform regulatory strategy and operations across CMC and clinical activities, leading a high-performing team to ensure compliance and successful product approvals from development through post-appr...

United StatesRemote

3 weeks ago

  •   15+ years exp.  •   Information Technology

$148K - $201K *

Drive category strategy and supplier relationships to enhance Market Access, Pricing, and Health Economics. Collaborate with cross-functional teams to optimize procurement processes and improve operat...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$250K - $300K *

Grow your career with a dynamic role leading customer acquisition in GenAI Safety Services. Own the full sales cycle, engage with senior stakeholders, and position strategic AI solutions to drive impa...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$173K - $290K *

Join a team that's redefining strategic research by tackling complex, ambiguous challenges. Collaborate with product, design, and engineering leaders to shape impactful insights that drive business de...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$110K - $130K *

Join us to minimize access barriers for patients and providers, executing market access plans across multiple states. Collaborate with healthcare professionals to resolve reimbursement issues and enha...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$210K - $249K *

Lead the vision and strategy for SRE across payments, driving reliability, automation, and incident management while scaling the function and fostering a culture of operational excellence and continuo...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.