Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$155K - $258K *

Shape the future of AI in healthcare by leading architectural design and technical strategy for LLM-powered systems. Mentor engineers, ensure compliance, and drive innovation in a highly regulated env...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Elevate patient care by driving oncology product success through strategic relationships and innovative solutions. Lead efforts in territory management, market analysis, and collaborative engagement t...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Partner with us to enhance client relationships and drive growth. In this role, you'll manage a diverse portfolio, ensuring customer retention and identifying new opportunities while collaborating wit...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Consumer Technology

$80K - $110K *

Transform clinical data into engaging scientific content with growth opportunities. Collaborate, communicate, and adhere to guidelines in a dynamic environment, supporting varied projects across forma...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$82K - $182K *

Analyze healthcare costs and quality outcomes to drive value-based care strategies, collaborating with clinical and financial teams. Lead data-driven insights and financial modeling to enhance operati...

RemoteRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Transform patient care by driving oncology product success through strategic relationships and innovative solutions. Lead market engagement, exceed performance goals, and ensure timely access to thera...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$190K - $220K *

Champion impactful scientific engagement by building relationships with key stakeholders, translating clinical data into actionable insights, and driving prelaunch strategies in a dynamic environment...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$180K - $210K *

Elevate creative excellence by leading a multidisciplinary team, setting vision and quality standards, and driving impactful brand strategies across diverse channels in a dynamic healthcare environmen...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$125K - $150K *

Join a cutting-edge team as a Senior Recruiter, responsible for sourcing and hiring top-tier quantitative researchers and data scientists to fuel innovative AI-driven investment strategies, enhancing...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$88K - $110K *

Unlock growth by owning the TPA/PEO sales strategy, managing complex accounts, and driving revenue across diverse deal sizes. Collaborate with cross-functional teams to deliver tailored solutions and...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$90K - $125K *

Transform complex commercial casualty claims management by leveraging your expertise in construction-related exposures and litigation. Collaborate with a dedicated team to deliver exceptional outcomes...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$160K - $192K *

Drive commercial performance by engaging healthcare providers and executing territory plans. Collaborate with cross-functional teams to support product launches and enhance patient access to innovativ...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $122K *

Take ownership of financial planning and analysis for G&A expenses, driving insights and reporting for senior leadership. Collaborate with teams to enhance budgeting, forecasting, and variance analysi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Transform healthcare operations by leading a dedicated team in a critical illness recovery hospital. Drive quality care, employee engagement, and strategic initiatives while ensuring compliance and op...

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Join a team that's shaping federal policy and advocacy. As a Government Affairs Manager, you'll engage with Congress and the Executive Branch, driving strategic initiatives across key domestic issues...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$115K - $130K *

Unlock potential by driving data analysis and interpreting clinical trial results. Collaborate with stakeholders, ensure statistical integrity, and contribute to innovative methodologies in biostatist...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$73K - $120K *

Drive the success of inpatient Payment Integrity programs by overseeing audits, ensuring compliance, and enhancing quality across teams and vendors. Collaborate with stakeholders to optimize processes...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $200K *

Lead client engagements by leveraging tax expertise to drive revenue growth, manage complex planning discussions, and enhance client relationships while ensuring strategic alignment across teams for o...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$111K - $167K *

Join a dynamic team as a strategic analytics partner, driving insights and performance improvements across revenue cycle operations. Collaborate with leaders to define KPIs, analyze data, and create i...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$108K - $130K *

Unlock your potential by leading customer projects, ensuring seamless communication, and driving success in healthcare solutions. Collaborate with diverse teams to enhance client satisfaction and oper...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $230K *

Shape the future of oncology by driving product success and building strong relationships with healthcare professionals. Lead initiatives that enhance patient access and deliver innovative solutions i...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $165K *

Build and manage clinical stewardship operations, driving client success through effective program implementation and cross-functional collaboration. Leverage clinical expertise to enhance client rela...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$129K - $185K *

Innovate global medical strategies for the Companion Animal Pain portfolio, driving growth and customer value through scientific engagement, KOL collaboration, and effective market implementation acro...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$175K - $210K *

Lead operational excellence in biopharmaceutical manufacturing, overseeing GMP processes, technology transfers, and clinical supply. Drive strategic initiatives, manage CDMO relationships, and build a...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Shape the future of talent acquisition by driving full life cycle recruitment for financial advisors. Collaborate with leadership and engage candidates to build a diverse talent pipeline while trackin...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.