Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$100K - $115K *

Unlock potential by providing vital sales support and presentations, driving customer integration and product utilization, while conducting market research to enhance offerings. Collaborate closely wi...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Lead the execution of clinical trials by monitoring site activities, ensuring compliance with regulations, and collaborating with teams to achieve study objectives. Play a key role in training site st...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$184K - $250K *

Accelerate progress at the forefront of application security, driving secure software development and fostering a culture of security across engineering teams while managing risks and enhancing securi...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Media

$92K - $124K *

Partner with us to enhance legal operations and implement eDiscovery processes. You'll lead customer data privacy initiatives, improving cross-functional collaboration and response strategies for comp...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$94K - $136K *

Transform financial insights into strategic decisions by providing advanced analytical support across Finance, Operations, and Strategic Planning. Collaborate with leadership to drive impactful projec...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Empower growth by leading private equity partnerships, driving telehealth solutions across portfolios. Build relationships, negotiate agreements, and create a repeatable deployment model to enhance he...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$140K - $155K *

Empower teams to elevate product design through strategic vision, fostering collaboration across disciplines to create impactful digital experiences that meet user needs and business goals while ensur...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Champion seamless communication by managing VoIP and telephony systems, ensuring optimal performance and user satisfaction. Collaborate across departments to analyze data, enhance workflows, and uphol...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$278K - $361K *

Accelerate progress at the forefront of software engineering leadership, driving innovation and operational excellence in regulated medical technology. Lead teams to deliver scalable, high-quality sof...

United StatesRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Healthcare

$78K - $98K *

Transform customer experiences by leading complex software implementations, ensuring seamless onboarding, testing, and launch activities. Leverage advanced product knowledge and project coordination s...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Join a team that's transforming procurement operations through innovative strategies and data-driven solutions. Leverage your consulting expertise to enhance client outcomes and drive impactful change...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$140K - $175K *

Drive operational excellence by leading strategic initiatives and managing a team to enhance Care Operations. Transform high-level strategies into scalable systems that improve care delivery and patie...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$180K - $215K *

Drive regional sales success by leading launch execution, building high-performing teams, and fostering customer relationships. Collaborate cross-functionally to achieve strategic goals in a fast-pace...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Inspire growth by leading regional launch strategies and building high-performing sales teams. Drive market success through strong customer relationships and cross-functional collaboration in a fast-p...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$70K - $142K *

Lead the charge in enhancing academic operations and faculty performance, ensuring compliance with accreditation standards while fostering student success through strategic curriculum development and...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Transform your career by leading operational excellence in a multi-practice medical environment. Drive improvements in efficiency, manage teams, and ensure the highest standards in patient care while...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$141K - $212K *

Deliver strategic oversight and operational management for FDA-mandated REMS programs, ensuring compliance, governance, and collaboration across teams and vendors to enhance program effectiveness and...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Transform nursing services by overseeing quality care for residents, managing a dedicated team, and ensuring compliance with health standards. Lead with passion and expertise in a supportive environme...

2 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Lead the nursing team in delivering exceptional care to residents while overseeing operations and ensuring quality standards. This role offers mentorship and growth opportunities in a supportive envir...

2 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Grow your career with a dynamic role overseeing nursing services, ensuring quality care for residents. Lead a dedicated team, manage operations, and enhance your professional development in a supporti...

2 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$115K - $158K *

Join us to shape the future of member experiences in healthcare by leading innovative design projects, collaborating with cross-functional teams, and enhancing service delivery through user-centered d...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$140K - $150K *

Shape the future of IT by leading a high-performing team to integrate AI and automation, enhance operational efficiency, and drive strategic technology initiatives in a dynamic environment...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$153K - $290K *

Transform drug discovery by leading a dynamic team in medicinal chemistry, driving innovative small-molecule candidates from concept to IND-ready status while fostering collaboration across a global n...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$255K - $310K *

Lead a high-performing team to execute market access strategies, optimize payer engagement, and enhance product positioning. Drive collaboration across stakeholders to ensure effective reimbursement a...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Drive the enhancement of Compliance Monitoring and Testing programs, ensuring regulatory alignment and effective risk management. Collaborate with stakeholders to improve operational efficiency and su...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.