Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$120K - $145K *

Join a team that shapes global regulatory strategy in a fast-paced environment. You will lead comprehensive regulatory plans, ensuring alignment and execution from development to post-marketing, impac...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$130K - $150K *

Champion effective publication strategies and lead scientific communication initiatives, acting as a strategic partner to clients and teams. Navigate complex medical affairs content to drive impactful...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$124K - $140K *

Accelerate your career by managing sales efforts for innovative products in gastroenterology. Cultivate relationships with healthcare professionals while driving business growth and addressing technic...

1 week ago

  •   Less than 5 years exp.  •   Staffing

$250K - $286K *

Shape the future of sales by leading a dynamic team to drive new business, refine strategies, and enhance customer experiences in a fast-paced SaaS environment, while mentoring leaders and achieving a...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Contribute to the success of multiple clinical research sites by leading operations, ensuring compliance with regulations, and fostering team development to enhance patient care and operational excell...

United StatesRemote

Reposted 1 month ago

  •   5 - 7 years exp.  •   Healthcare

$176K - $243K *

Accelerate progress at the forefront of cardiovascular innovation, leading a dynamic team to drive the adoption of advanced imaging solutions in the U.S. market, while fostering strategic partnerships...

United StatesRemote

Reposted yesterday

  •   11 - 15 years exp.  •   Healthcare

$195K - $256K *

Elevate clinical quality assurance by designing and executing strategies for compliance, audit management, and oversight of global clinical operations. Collaborate with stakeholders to ensure adherenc...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$92K - $138K *

Deliver clinical expertise and training support for XR products, enhancing customer experience and operational efficiency. Collaborate with sales and clinical teams to drive education initiatives and...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Business Services

$88K - $105K *

Shape the future of patient care by leading Interventional Radiology operations. Oversee clinical management, enhance patient satisfaction, and drive financial performance while collaborating with mul...

3 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$160K - $200K *

Lead the charge in analytical development, overseeing drug substance and product strategies. Collaborate across teams to ensure compliance and performance, while mentoring a high-performing analytical...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$250K - $300K *

Champion innovative radiology practices to enhance patient care and operational efficiency alongside a dynamic team. Drive clinical excellence and leverage technology to elevate standards across healt...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Healthcare

$212K - $287K *

Transform the Hematology landscape by leading a high-performing sales team, driving strategic initiatives, and ensuring compliance while exceeding sales objectives in the Great Plains region...

RemoteRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Shape the future of healthcare by leading regional sales efforts, driving product launch success, and building high-performing teams. Collaborate cross-functionally to achieve sales goals and foster s...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Unlock potential by leading Health and VA claims operations, driving strategic initiatives, enhancing recovery outcomes, and ensuring operational excellence across multiple teams and client portfolios...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$160K - $200K *

Drive strategic excellence in healthcare by leading business development, planning, and population health initiatives. Collaborate with teams to ensure that the mission and values guide MercyOne’s evo...

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $100K *

Join a team that's dedicated to delivering high-quality psychotherapy to older adults. Enjoy flexible scheduling, comprehensive support, and the opportunity to make a meaningful impact in a collaborat...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Unlock your potential as a senior Epic Willow Analyst, leading pharmacy workflow configurations and supporting clinical applications in a dynamic healthcare environment. Collaborate with teams to opti...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$180K - $215K *

Transform your career by leading regional sales efforts, driving product launch success, and building high-performing teams. Collaborate cross-functionally to achieve sales goals and foster strong cus...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Join a team that's dedicated to advancing NMR technology and research. Oversee facility operations, manage user access, and provide expert support to a diverse group of researchers while ensuring safe...

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $150K *

Champion clinical project success by leading operations, training teams, and ensuring compliance. Drive strategic planning and risk management while overseeing site performance and fostering collabora...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $110K *

Design and develop advanced analytics solutions, transforming complex healthcare data into actionable insights using Azure Databricks and Power BI. Collaborate with cross-functional teams to enhance r...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$175K - $215K *

Launch impactful product initiatives by bridging engineering and design while driving user-centered solutions and leveraging AI tools for enhanced workflows in a high-growth environment...

RemoteRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$180K - $220K *

Lead the charge in developing clinical content strategies and overseeing teams within the market access practice. Drive innovation, enhance client strategies, and ensure high standards in service deli...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Join a team that's redefining telehealth by delivering exceptional psychotherapy to older adults. Enjoy flexible hours, comprehensive support, and opportunities for professional growth while making a...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $140K *

Empower healthcare providers by promoting innovative colorectal cancer screening solutions, delivering exceptional support and education while strategically expanding product adoption across a designa...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.