BristolMyers Squibb

Principal Scientist, LNP Process Development & MS&T

BristolMyers Squibb • $153K — $186K *
Cambridge, MA 02139In-Person
Pharmaceuticals & Biotech
Less than 5 years of experience
Today
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Job Overview by Ladders

Qualifications

  • Degree in Bio/Chemical Engineering, Bio/Chemistry or related field (MS with 8+ years' or PhD with 3+ years' experience).
  • Expertise with lipid nanoparticle formation and conjugation reactions.
  • Working knowledge of statistical design of experiments (DoE).
  • Experience with biophysical characterization techniques like DLS and Encapsulation Efficiency.
  • Experience working with clinical manufacturing sites.
  • Knowledge of cGMP, ICH guidelines, and QbD principles.
  • Exceptional communication skills for technical and non-technical audiences.

Responsibilities

  • Lead tech transfer to clinical production sites, ensuring success.
  • Provide oversight and hands-on scientific input for process development.
  • Employ high throughput data approaches to assess and mitigate risks.
  • Represent development strategies in cross-functional CMC teams.
  • Set priorities for LNP PD MSAT in alignment with organizational goals.
  • Mentor and develop talent to foster a culture of excellence.
  • Initiate departmental improvements for workflows and efficiency.

Benefits

  • Comprehensive health coverage including medical, dental, and vision care.
  • Wellbeing support programs such as Employee Assistance Programs.
  • Financial protection through a 401(k) plan, disability insurance, and life insurance.
  • Flexible paid time off, including summer hours and paid volunteer days.
Full Job Description
The Principal Scientist, LNP Process Development & MS&T plays a central role in enabling the success of batches in clinical development across multiple products. Connecting with both the larger LNP PD team and with research to develop clinical scale batches that are representative across scales and sites.

The Principal Scientist is a scientific leader responsible for driving clinical manufacturing strategy, influencing cross-functional decisions, and delivering high-impact outcomes across an increasingly diverse portfolio.

Position Summary

The Principal Scientist provides scientific leadership for bulk drug product programs spanning preclinical to early-stage development and leading the tech transfer and implementation of process into clinical production. This role is primarily focused on hands-on scientific contribution by driving sound experimental execution and establishing the linkage from small scale process to manufacturing implementation at scale in a GMP environment.

Key Responsibilities

Scientific Leadership
  • Lead the tech transfer from nonclinical production and development to a clinical production site, interfacing with site leadership to ensure clinical production success.
  • Provide strategic oversight of process development and manufacturability, while contributing hands-on scientific input where needed to resolve critical technical challenges.
  • Apply high throughput data drive approaches to assess and mitigate risks, defining mitigation strategies and making critical scientific recommendations at key program milestones
  • Represent bulk drug product development strategies in cross-functional CMC teams, ensuring alignment across research, analytical development, engineering, regulatory affairs, and supply chain


People Leadership & Talent Development
  • Set clear priorities and objectives for LNP PD MSAT in alignment with portfolio goals and LNP PD's broader organizational strategy
  • Mentor and develop scientists across LNP PD MSAT, contributing to a culture of scientific excellence and continuous learning
  • Foster an inclusive, high-performance team environment built on psychological safety, accountability, and collaboration


Innovation & Organizational Contribution
  • Propose and lead departmental initiatives that improve scientific workflows, sustainability practices, and operational efficiency
  • Build and maintain collaborative relationships with external academic institutions and industry partners to accelerate scientific advancement
  • Represent capabilities at internal reviews, scientific conferences, and through peer-reviewed publications


Cross-Functional Collaboration
  • Serve as a key scientific voice in cross-functional CMC teams and broader enterprise forums
  • Partner with functional areas - including research, analytical development, engineering, and drug substance development
  • Collaborate with organization leadership to drive strategic alignment across the portfolio


Qualifications & Experience
  • Degree in Bio/Chemical Engineering, Bio/Chemistry, or related field MS with 8+ years' or PhD with 3+ years' experience in science related disciplines
  • Expertise with lipid nanoparticle formation, conjugation reactions, and tangential flow filtration unit operations
  • Working knowledge of statistical design of experiments (DoE) and analysis of multivariate data
  • Experience with performing and interpreting process analytics and biophysical characterization techniques such as DLS and Encapsulation Efficiency
  • Experience working with both internal and external clinical manufacturing sites
  • Knowledge of cGMP, ICH, regulatory guidelines and QbD principles as they apply to risk management and clinical manufacturing
  • Exceptional written and oral communication skills, with the ability to convey complex scientific concepts clearly to both technical and non-technical audiences
  • Ability to lead complex projects independently and influence decisions across matrixed teams and governance forums.
  • Prior experience managing, mentoring, or developing scientists in an industrial setting
  • Demonstrated background working in a GMP environment and supporting change controls, developing clinical strategies, and resolving deviations in conjunction with Quality teams
  • Knowledge of advanced mathematics, nucleic acid chemistry, lipid chemistry, and biology is a plus
  • Knowledge of establishing and qualifying scale down models and mechanistic models for process characterization is a plus
  • May require international travel

If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Compensation Overview:

Cambridge - MA - US: $153,660 - $186,203

The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee's work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/.

Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include:
  • Health Coverage: Medical, pharmacy, dental, and vision care.
  • Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
  • Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.


Work-life benefits include:

Paid Time Off
  • US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)
  • Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays


Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.

All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

*Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program.

About BristolMyers Squibb

BristolMyers Squibb Careers

Join the vibrant team at BristolMyers Squibb, a leader in global biopharmaceutical innovation, where your career growth is as important as the life-changing solutions we develop. At BristolMyers Squibb, we are committed to fostering a diverse and inclusive workplace that encourages professional growth and development. Work You’ll Do Embark on a career with BristolMyers Squibb and be part of a company that’s dedicated to discovering, developing, and delivering innovative medicines that help patients prevail over serious diseases. With us, you’ll contribute to a culture that embraces scientific innovation, responsible leadership, and community outreach. Explore job opportunities in various fields from research to marketing, and join a team that values leadership and diversity. Our commitment to career growth means we support your journey with extensive training programs, leadership development opportunities, and a global, diverse network of professionals. Innovative Work At BristolMyers Squibb, innovation is at the core of everything we do. From pioneering research in oncology to breakthroughs in immunology, our professionals have the opportunity to make significant contributions to the field and impact lives globally. Our collaborative environment encourages team members to challenge the status quo and bring forward ideas that pave the way for groundbreaking solutions. Be Part of a Great Team Working at BristolMyers Squibb means being part of a team that supports your aspirations and shares your values. Our culture thrives on teamwork, respect, and diversity, creating a workplace where everyone can achieve their potential. Enjoy the benefits of being part of a company that values work-life balance, provides competitive benefits, and fosters an environment where skills and leadership are developed through hands-on experience and comprehensive mentorship programs. Future-Proof Your Career With a multitude of job opportunities ranging from internships to full-time positions, BristolMyers Squibb is not just hiring; we’re building futures. We equip our employees with the tools needed for success, including advanced training in diverse skill sets, leadership programs, and opportunities for professional networking and growth. Stay Connected Join Our Team Search open positions that match your skills and interests. We are looking for passionate, curious, and innovative team players who are ready to make a difference. Explore our career portal for all current job listings and be sure to submit your resume. Keep Up to Date Stay informed with the latest company news, career tips, and industry insights from BristolMyers Squibb. Our careers blog is a resource for potential and current employees looking to maximize their career potential. Job Alert Emails Customize your subscription to receive job alerts and insider information tailored to your preferences. Discover the exciting and rewarding career opportunities that await at BristolMyers Squibb. At BristolMyers Squibb, your career is just the beginning – it’s a pathway to personal and professional fulfillment. Join us and make a global impact.
Learn more about BristolMyers Squibb
Size
32,200 employees
Market Cap
$156.3 billion
Industry
Pharmaceuticals & Biotech
Net Income
-$9 billion
Founded
1887
5 Year Trend
+19%
Revenue
$42.5 billion
NASDAQ
BMY
* Ladders Estimates

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