Otsuka Pharmaceuticals

Principal ML Engineer

Otsuka Pharmaceuticals$172K — $258K *
Information Technology
5 - 7 years of experience
Job Overview by Ladders

Qualifications

  • 5-7 years of experience in machine learning and AI systems
  • Proficiency in Python and libraries like PyTorch and Hugging Face
  • Experience managing large datasets and production ML systems on AWS
  • Familiarity with model-serving frameworks and deployment tools
  • Strong understanding of various machine learning architectures
  • Demonstrated ability to lead technical direction and mentor team members
  • Ph.D. or Master’s degree in a quantitative field, or equivalent experience.

Responsibilities

  • Develop and manage end-to-end ML systems, from data sourcing to model monitoring
  • Define ML architecture for optimized threat-detection systems
  • Set technical direction for production model serving using advanced AWS tools
  • Benchmark and prototype ML alternatives for informed decision-making
  • Establish standards for reproducible ML and shared workflows
  • Enhance model observability and monitoring practices
  • Manage capacity planning and rollout strategies across the ML landscape
  • Collaborate with cross-functional teams to align on technical roadmaps.

Benefits

  • Provides a conducive office environment fostering collaboration
  • Utilizes cutting-edge AI development tools
  • Opportunities for professional mentoring and development
  • Encourages cross-team integration and learning
  • Access to advanced ML and AI production frameworks.
Full Job Description

Principal Machine Learning Engineer


Overview

As a Principal Machine Learning Engineer, you will set technical direction for Mimecast's ML capabilities, including our GCI products or advanced email threat-detection products. This is a senior individual-contributor role: you will own the hardest modeling and systems problems end to end, define the architecture other engineers build on, and be a technical authority for product and engineering leadership when the direction is not obvious.

Our threat ML runs on Mimecast's shared AI enrichment platform, the detection and extraction infrastructure serving models across the product suite. You will work at the intersection of applied ML, production model serving, and cross-team integration, making architectural decisions that hold up under production load and customer commitments.

Mimecast is an AI-first engineering organization. You will use AI development tools, including Claude Code, Cursor, and MCP integrations, in your daily work and establish the workflows, patterns, and quality bar for the team. You will also design product systems using LLM and agent-based patterns.

Employees are expected to work from the office at least two days per week. This fosters collaboration, communication, performance, and learning; drives innovation and creativity within and between teams; introduces employees to priorities beyond their immediate realm; and supports important interpersonal relationships and connections.


What You'll Do
  • Develop and own ML systems end to end, from data sourcing, cleaning, and labeling strategy through feature engineering, model development, deployment, and monitoring.

  • Set the ML architecture across model design, serving, and surrounding systems, optimizing accuracy, latency, and throughput for highly imbalanced threat-detection data.

  • Set technical direction for production model serving using AWS SageMaker, NVIDIA Triton Inference Server, ensemble/KServe patterns, hardened container images, and integration with enrichment and gateway layers.

  • Benchmark and prototype alternatives to de-risk major decisions, then give leadership defensible technical recommendations.

  • Establish reproducible ML standards, including versioned datasets, region-partitioned data, and shared experimentation workflows.

  • Make model observability and efficacy measurement first-class concerns through distributed tracing, threshold-independent metrics, raw-payload capture, and monitoring for real regressions.

  • Own capacity planning and rollout strategy, including throughput per core or GPU, utilization headroom, peak-load provisioning, and phased regional canary or shadow deployments.

  • Diagnose production incidents, close the structural gaps they expose, and act as a primary reviewer and mentor across the ML codebase.

  • Partner with Product, platform engineering, and adjacent teams to shape the roadmap and communicate technical complexity and business implications through engineering and product leadership.


What You'll Bring
  • Breadth across transformer architectures, RNNs, CNNs, generalized linear models, and gradient-boosted trees, with the judgment to select the right approach for the problem rather than defaulting to the largest model.

  • Deep Python proficiency and strong command of PyTorch, Hugging Face transformers, and NLP tooling, plus working knowledge of ONNX Runtime, quantization such as FP16, and inference acceleration.

  • Experience with dense and lexical retrieval, including embeddings, vector indexes and approximate nearest-neighbor search, BM25, TF-IDF, and hybrid approaches.

  • Experience working with datasets exceeding two million examples and highly imbalanced data, using rigorous evaluation methods for precision and recall trade-offs, threshold selection, and test-set leakage prevention.

  • A track record of owning production ML systems on AWS, including SageMaker, S3, Athena, Lambda, Glue, Kinesis, and Bedrock, with Terraform, IAM, containers, and Kubernetes-based deployment.

  • Working knowledge of model-serving frameworks such as TorchServe, FastAPI, and NVIDIA Triton Inference Server/KServe, and the trade-offs among throughput, GPU efficiency, flexibility, and speed of iteration.

  • Hands-on experience running CUDA workloads in production, including driver, toolkit, and runtime alignment; GPU passthrough in containers; debugging GPU failures; and improving GPU utilization.

  • Fluency with AI-native development tools and modern LLM application patterns, including OpenAI-style chat-completion and structured tool/function-calling APIs, MCP, and agent frameworks.

  • Demonstrated technical leadership as an individual contributor, including setting direction, mentoring engineers across seniority levels, and communicating technical decisions and their business implications to technical and executive audiences.

  • An understanding of handling sensitive data in accordance with Master Service Agreements and compliance requirements.

  • A Ph.D. or Master's degree in a quantitative discipline, such as computer science, statistics, or mathematics, with substantial experience applying advanced ML to production problems; or equivalent depth demonstrated through a Bachelor's degree and a longer track record. We value demonstrated technical authority over a specific year count.

The base salary range for this position is $172,000 - $258,000 USD plus benefits. This range represents the minimum and maximum new hire compensation for this role. The position may also be eligible for incentive plans and additional benefits, in accordance with company policy and local regulations. Our salary ranges are determined by role, level, and location with individual compensation also dependent on factors such as qualifications, experience, and skills. Final offers will reflect these considerations and may vary accordingly.

About Otsuka Pharmaceuticals

Otsuka Pharmaceutical is a Japanese pharmaceutical company that develops and markets a range of products including prescription drugs, over-the-counter medications, and nutritional supplements. The company was founded in 1964 and is headquartered in Tokyo, Japan. Otsuka Pharmaceutical has a strong research and development program and has developed several innovative drugs for the treatment of various diseases. The company is committed to sustainability and has implemented several initiatives to reduce its environmental impact. Otsuka Pharmaceutical has a global presence and operates in several countries around the world.
Learn more about Otsuka Pharmaceuticals
Size
9,171 employees
Industry
Founded
1989
NASDAQ

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