Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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$100K - $140K *

Elevate your career by developing innovative embedded software solutions. Collaborate with cross-functional teams to design, implement, and support complex systems, utilizing your technical expertise...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Lead advanced troubleshooting and repair of medical equipment, ensuring customer satisfaction through service excellence. Collaborate with teams, mentor junior engineers, and drive initiatives to enha...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$137K - $182K *

Architect and drive AI-powered applications for drug development, focusing on protocol generation and clinical trials. Lead technical direction, mentor engineers, and ensure compliance while fostering...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$123K - $218K *

Champion user-centered information experiences by leading a distributed team to create impactful technical documentation and content strategies that enhance customer and developer engagement across mu...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$95K - $115K *

Join a team that's dedicated to engineering excellence in the oil & gas sector. As a Senior Instrumentation and Controls Engineer, you will design low voltage systems, mentor junior engineers, and ens...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$78K - $131K *

Engage in innovative software engineering solutions, building robust agents and integrating LLMs while ensuring compliance and security. Collaborate with teams to enhance service boundaries and orches...

Today

  •   Less than 5 years exp.  •   Business Services

$78K - $131K *

Develop innovative software solutions by integrating LLMs and building agents within a layered SDK. Collaborate with teams to enforce service boundaries and enhance tenant isolation while ensuring hig...

Today

  •   Less than 5 years exp.  •   Business Services

$130K - $160K *

Unlock your potential as a Senior Full Stack Software Engineer, leading impactful projects and shaping technology solutions. Collaborate across web applications, backend services, and cloud infrastruc...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Unlock potential by driving the digital transformation of aerospace manufacturing. Collaborate with engineers to design smart systems that enhance operational efficiency and decision-making through ad...

Yesterday

  •   5 - 7 years exp.  •   Aerospace & Defense

$110K - $130K *

Champion the integration of digital systems in a cutting-edge aerospace manufacturing facility, enhancing operational efficiency through data architecture, advanced analytics, and real-time decision s...

Yesterday

  •   5 - 7 years exp.  •   Aerospace & Defense

$100K - $120K *

Transform the future of secure, reliable applications and cloud services by leveraging modern software engineering and DevOps practices to enhance delivery, security, and developer experience in a col...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Legal & Accounting

$154K - $185K *

Join our dynamic team to develop next-gen storage solutions, enhancing Grafana's App Platform. Collaborate on innovative features, drive projects from ideation to operations, and contribute to an open...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$73K - $212K *

Unlock potential by leading innovative AI solutions and managing client accounts. Collaborate with teams to analyze complex data sets, drive continuous improvement, and deliver exceptional results whi...

2 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$73K - $212K *

Champion innovative AI solutions by leading a dynamic team to deliver exceptional client outcomes. Drive data-driven decision-making through advanced analytics while fostering strong client relationsh...

2 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$145K - $269K *

Drive excellence in systems integration as the On-Site Engineering Lead, managing test plans and validation activities for complex systems. Collaborate with teams to ensure successful execution and do...

2 days ago

  •   11 - 15 years exp.  •   Aerospace & Defense

$118K - $148K *

Drive product and process optimization initiatives across manufacturing, enhancing cost, quality, and safety. Collaborate with cross-functional teams to implement sustainable improvements and lead com...

2 days ago

  •   5 - 7 years exp.  •   Food & Beverages

$170K - $230K *

Join a team that's redefining SoC design by owning subsystem development, integrating third-party IP, and optimizing PPA for next-gen architectures. Contribute across all design stages and drive impac...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$150K - $180K *

Pioneer innovative solutions as a Senior Manager in Deployed Engineering, leading hands-on deployments and building a high-performing team. Collaborate closely with customers and internal teams to dri...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$90K - $110K *

Optimize finance systems by administering and enhancing ERP solutions, ensuring seamless integration and data integrity. Collaborate with cross-functional teams to drive system improvements and suppor...

3 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$65K - $126K *

Join a team that's dedicated to optimizing mainframe network systems. Leverage your expertise in planning, installing, and maintaining software while ensuring system performance and reliability. Colla...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$244K - $279K *

Champion innovative AI solutions by collaborating with diverse teams to design, develop, and deploy cutting-edge AI systems that revolutionize customer engagement and operational efficiency. Grow your...

RemoteRemote

4 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$92K - $115K *

Drive test automation excellence by designing and maintaining robust frameworks, collaborating across teams to enhance QA capabilities, and leveraging AI tools to optimize testing processes and reduce...

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$92K - $115K *

Engineer robust end-to-end test automation frameworks using Playwright. Collaborate across teams to enhance QA capabilities, leveraging AI tools for efficient testing and maintenance, while mentoring...

Pittsburgh, PARemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in defining and executing critical technical programs, enhancing research infrastructure while ensuring impactful collaboration across teams. Empower researchers to translate their wor...

RemoteRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Unlock automation potential by leading projects from concept to execution, enhancing production efficiency through innovative solutions and hands-on troubleshooting in a dynamic manufacturing environm...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.