Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Senior Counsel Jobs in Missouri

Sort By: Relevance

$78K - $88K *

Join us to perform actuarial analyses and support healthcare consulting projects. Collaborate with multidisciplinary teams to develop insights, maintain models, and communicate findings effectively wh...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$150K - $220K *

Oversee a specialized team to ensure AI safety in biological research, addressing dual-use risks and providing expert guidance on complex cases while mentoring junior specialists and advising clients...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$145K *

Drive innovation and transform lives by leading regulatory strategies and submissions for clinical trials globally. Act as a key liaison for project teams to ensure compliance, operational excellence...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$217K - $271K *

Launch your career by owning the national Field Excellence model, managing operations for a groundbreaking oncology therapy. Collaborate with sales leaders to enhance prescriber access and streamline...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Join a dynamic team to create impactful visual solutions for healthcare audiences. Collaborate with cross-functional teams to manage creative workflows and elevate brand presence across print and digi...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$187K - $359K *

Transform your career by leading integration enablement initiatives that enhance acquisition strategies. Collaborate with executives to develop governance frameworks and tools, ensuring effective inte...

3 weeks ago

  •   8 - 10 years exp.  •   Legal & Accounting

$187K - $359K *

Drive integration management capabilities to enhance acquisition success. Collaborate with stakeholders to develop frameworks, tools, and best practices, ensuring effective execution and governance ac...

3 weeks ago

  •   8 - 10 years exp.  •   Legal & Accounting

$101K - $154K *

Shape the future of enterprise partnerships by driving value through collaboration with Sales, Product, and Marketing teams. Leverage your expertise to identify ROI opportunities and enhance customer...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$104K - $153K *

Unlock your potential by leading the technical delivery of workforce applications. Collaborate with teams to enhance productivity through automation, AI, and integrations, ensuring secure and efficien...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Drive customer success by managing enterprise accounts, ensuring retention and growth through strategic partnerships and data-driven insights. Collaborate cross-functionally to enhance customer experi...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$160K - $200K *

Lead the charge in strategic client services management, overseeing growth, engagement, and high-value account portfolio. Drive team performance and build enduring client relationships that enhance bu...

United StatesRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$103K - $161K *

Drive strategic growth by establishing and nurturing key partnerships with Enterprise Claims carriers, ensuring service excellence and collaboration across internal teams to enhance business outcomes...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Lead the charge in enhancing branch performance through innovative learning strategies. Collaborate with stakeholders to identify gaps, develop solutions, and drive adoption of new skills, ensuring te...

4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Transform complex fire protection challenges into innovative solutions by leading advanced fire, smoke, and egress modeling projects. Collaborate with multidisciplinary teams to ensure compliance and...

4 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$62K - $146K *

Inspire a high-performing sales organization by leading and developing Sales Managers across a multi-agency territory, driving revenue growth, and shaping the future of your district while enhancing c...

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $120K *

Drive revenue growth by leading high-performing sales teams and executing strategic sales initiatives. This role combines leadership with deep expertise in performance marketing to achieve ambitious b...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Media

$110K - $130K *

Champion strategic alliances to drive growth, enhance partnerships, and align cross-functional teams. Lead initiatives that translate company goals into actionable plans, ensuring measurable results a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$77K - $91K *

Lead the charge in delivering exceptional project management services, ensuring seamless communication and collaboration with builders while achieving safety and quality goals throughout the project l...

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Optimize clinical trial operations by leading cross-functional teams, managing vendor relationships, and ensuring compliance with regulatory standards to drive successful study execution and patient e...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $160K *

Join a team that's committed to enhancing our cybersecurity and GRC programs. You'll drive initiatives across risk management, compliance, and operational security, playing a vital role in strengtheni...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$84K - $127K *

Elevate participant engagement by providing expert retirement education and support. Drive enrollment, enhance savings, and foster strong relationships with clients while achieving service goals and p...

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$105K - $135K *

Transform product vision into reality by driving execution and collaboration across teams. Leverage data and AI to enhance risk data accessibility, ensuring customers can act swiftly and confidently o...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$95K - $115K *

Lead the charge in managing complex projects and mentoring teams while ensuring client satisfaction and technical excellence. Drive project success through effective communication and coordination wit...

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Unlock potential by driving sales growth through strategic partnerships with agents and agencies. Collaborate to develop and implement innovative marketing strategies that enhance customer service whi...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$130K - $180K *

Join a team that's redefining data products on a modern platform. As a Senior Technical Product Manager, you'll drive the strategy for our data platform and API, ensuring quality, governance, and a se...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Staffing

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.