Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Business Development and Marketing Specialist - Litigation | Labor & Employment
$90K - $120K *
Support and enhance business development initiatives for Litigation and Labor & Employment Departments. Collaborate with senior managers and attorneys to drive client engagement, execute marketing str...
5 days ago
Regulatory Affairs Consultant - Regulatory Generalist
$100K - $120K *
Take ownership of regulatory support for pharmaceutical programs, managing IND and NDA submissions, health authority interactions, and lifecycle maintenance. Collaborate with cross-functional teams to...
3 weeks ago
$68K - $113K *
Join a team that's dedicated to transforming disability claims through expert clinical assessments. Collaborate with healthcare providers and utilize your clinical expertise to improve patient outcome...
Reposted 2 weeks ago
Senior Manager, PMO (P&C Insurance)
$140K - $175K *
Lead transformative insurance program initiatives, overseeing technology enhancements and operational workflows. Collaborate across teams to drive project management and ensure compliance, while optim...
Reposted today
$210K - $250K *
Accelerate success by leading our BEC Legal Systems business, driving strategic direction, P&L ownership, and operational excellence to enhance customer satisfaction and market leadership in B2B SaaS...
Reposted 2 weeks ago
$140K - $165K *
Join a team that's redefining healthcare technology by owning the product roadmap, translating company goals into actionable tasks, and ensuring seamless delivery of AI-driven solutions that enhance p...
Today
$120K - $250K *
Transform clinical trials by ensuring patient safety and scientific integrity. Collaborate with stakeholders to uphold regulatory standards and optimize study protocols, while providing expert medical...
3 weeks ago
$220K - $300K *
Shape the future of financial strategy by leading comprehensive reporting, planning, and analysis. Collaborate with cross-functional teams to enhance decision-making and drive performance, while ensur...
Reposted 5 days ago
Project Manager, Industry Specialty Services
$125K - $165K *
Manage technology implementations and strategic projects, coordinating across stakeholders to ensure successful delivery while adhering to budgets, schedules, and quality standards. Leverage project m...
Today
$138K - $172K *
Empower revenue teams as a Senior Business Systems Analyst, driving efficiency through Salesforce architecture, process design, and actionable data across GTM, Marketing, Sales, and Customer Success o...
Reposted 1 week ago
Assistant Vice President - Captive Solutions
$165K - $200K *
Transform captive program management by driving portfolio growth, enhancing underwriting practices, and fostering strong partner relationships. Join a dynamic team to shape innovative solutions and de...
5 days ago
$104K - $174K *
Champion the development of sales professionals by designing and delivering impactful training programs. Collaborate with leadership to enhance skills, knowledge, and effectiveness, ensuring a consist...
Today
Vice President, Executive Planning Consultant - Southeast Market
$160K - $200K *
Lead the charge in providing tailored financial planning and investment strategies for senior executives. Collaborate with a dedicated team to enhance client relationships and drive business growth wh...
5 days ago
$82K - $153K *
Unlock potential by driving acquisition strategies and building relationships with agency owners. Collaborate with leadership to enhance deal pipelines and support growth initiatives through effective...
5 days ago
$100K - $120K *
Strategize and lead tax initiatives, ensuring compliance and operational excellence while collaborating with cross-functional teams to drive process improvements and enhance business performance...
2 weeks ago
Manager FP&A - Private Equity Advisory
$110K - $130K *
Elevate your career by partnering with clients to enhance FP&A processes, build financial models, and drive operational improvements in a dynamic Private Equity environment. Collaborate with teams to...
2 weeks ago
Senior Employee Assistance Plan (EAP) Counselor
$80K - $100K *
Join a team that's dedicated to enhancing employee well-being through expert counseling and support. Provide confidential mental health services to federal employees, addressing personal challenges th...
2 weeks ago
Senior Clinical Project Manager
$120K - $145K *
Join a team that's advancing oncology solutions by managing global clinical trials. Lead project execution from protocol development to study closeout, ensuring quality and compliance while fostering...
3 weeks ago
VP, Global Government Affairs & Strategic Policy
$180K - $220K *
Lead the development and execution of global government affairs strategies, fostering relationships with key stakeholders and providing strategic counsel on policy and regulatory matters impacting the...
3 weeks ago
$100K - $160K *
Lead critical evaluations of biological risks, mentor junior specialists, and ensure high-quality labeling for AI safety classifiers in a dynamic life-sciences environment focused on biodefense and bi...
1 week ago
Senior Engineering Consultant - Civil/Construction
$110K - $130K *
Champion client success by leading complex commercial real estate projects, managing multi-site portfolios, and providing senior technical expertise to multidisciplinary teams, ensuring effective deli...
Reposted 1 week ago
Director, Professional Services Group
$120K - $150K *
Join a team that's shaping the future of consulting in P&C insurance. Lead client engagements, ensure quality standards, and foster long-term relationships while driving business growth and mentoring...
3 weeks ago
Senior Director, Product, Security and Privacy Counsel
$260K - $300K *
Partner with us to ensure our products meet legal standards while fostering innovation. Collaborate with cross-functional teams throughout the product lifecycle, from design to launch, enabling respon...
4 days ago
Senior Partner Account Manager
$110K - $130K *
Transform partner relationships into measurable success by managing a strategic portfolio of technology and advisory partners. Collaborate across teams to drive growth, co-sell, and enhance operationa...
3 weeks ago
Senior Director / Director , Breast Oncology Lifecycle Management
$186K - $233K *
Pioneer innovative strategies in breast oncology, driving commercial success through collaboration and data-driven insights. Lead cross-functional teams to enhance product adoption and optimize market...
3 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.